KEGG   PATHWAY: ko03040Help
Entry
ko03040                     Pathway                                

Name
Spliceosome
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Spliceosome
ko03040

All organismsOrtholog table
Module
M00351  
Spliceosome, U1-snRNP [PATH:ko03040]
M00352  
Spliceosome, U2-snRNP [PATH:ko03040]
M00353  
Spliceosome, Prp19/CDC5L complex [PATH:ko03040]
M00354  
Spliceosome, U4/U6.U5 tri-snRNP [PATH:ko03040]
M00355  
Spliceosome, 35S U5-snRNP [PATH:ko03040]
M00396  
Lsm 2-8 complex [PATH:ko03040]
M00398  
Sm core complex [PATH:ko03040]
M00399  
Cap binding complex [PATH:ko03040]
M00405  
THC complex [PATH:ko03040]
M00406  
TREX complex [PATH:ko03040]
M00430  
Exon junction complex (EJC) [PATH:ko03040]
Disease
H00527  
Retinitis pigmentosa (RP)
H01376  
Acrofacial dysostosis
Other DBs
BSID: 
GO: 
Orthology
K14276  
U1 spliceosomal RNA
K14277  
U2 spliceosomal RNA
K14278  
U4 spliceosomal RNA
K14279  
U5 spliceosomal RNA
K14280  
U6 spliceosomal RNA
K12811  
ATP-dependent RNA helicase DDX46/PRP5 [EC:3.6.4.13]
K12812  
ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13]
K12813  
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [EC:3.6.4.13]
K12814  
pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 [EC:3.6.4.13]
K12815  
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 [EC:3.6.4.13]
K12816  
pre-mRNA-processing factor 17
K12817  
pre-mRNA-splicing factor 18
K12818  
ATP-dependent RNA helicase DHX8/PRP22 [EC:3.6.4.13]
K12819  
pre-mRNA-processing factor SLU7
K12820  
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 [EC:3.6.4.13]
K11086  
small nuclear ribonucleoprotein B and B'
K11087  
small nuclear ribonucleoprotein D1
K11096  
small nuclear ribonucleoprotein D2
K11088  
small nuclear ribonucleoprotein D3
K11097  
small nuclear ribonucleoprotein E
K11098  
small nuclear ribonucleoprotein F
K11099  
small nuclear ribonucleoprotein G
K11093  
U1 small nuclear ribonucleoprotein 70kDa
K11091  
U1 small nuclear ribonucleoprotein A
K11095  
U1 small nuclear ribonucleoprotein C
K12821  
pre-mRNA-processing factor 40
K12822  
RNA-binding protein 25
K12823  
ATP-dependent RNA helicase DDX5/DBP2 [EC:3.6.4.13]
K12824  
transcription elongation regulator 1
K11092  
U2 small nuclear ribonucleoprotein A'
K11094  
U2 small nuclear ribonucleoprotein B''
K12825  
splicing factor 3A subunit 1
K12826  
splicing factor 3A subunit 2
K12827  
splicing factor 3A subunit 3
K12828  
splicing factor 3B subunit 1
K12829  
splicing factor 3B subunit 2
K12830  
splicing factor 3B subunit 3
K12831  
splicing factor 3B subunit 4
K12832  
splicing factor 3B subunit 5
K12833  
pre-mRNA branch site protein p14
K12834  
PHD finger-like domain-containing protein 5A
K12835  
ATP-dependent RNA helicase DDX42 [EC:3.6.4.13]
K12836  
splicing factor U2AF 35 kDa subunit
K12837  
splicing factor U2AF 65 kDa subunit
K12838  
poly(U)-binding-splicing factor PUF60
K12839  
survival of motor neuron-related-splicing factor 30
K12840  
splicing factor 45
K12841  
calcium homeostasis endoplasmic reticulum protein
K12842  
U2-associated protein SR140
K12621  
U6 snRNA-associated Sm-like protein LSm2
K12622  
U6 snRNA-associated Sm-like protein LSm3
K12623  
U6 snRNA-associated Sm-like protein LSm4
K12624  
U6 snRNA-associated Sm-like protein LSm5
K12625  
U6 snRNA-associated Sm-like protein LSm6
K12626  
U6 snRNA-associated Sm-like protein LSm7
K12627  
U6 snRNA-associated Sm-like protein LSm8
K12843  
U4/U6 small nuclear ribonucleoprotein PRP3
K12662  
U4/U6 small nuclear ribonucleoprotein PRP4
K09567  
peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]
K12844  
U4/U6 small nuclear ribonucleoprotein PRP31
K12845  
U4/U6 small nuclear ribonucleoprotein SNU13
K12846  
U4/U6.U5 tri-snRNP-associated protein 3
K12847  
U4/U6.U5 tri-snRNP-associated protein 2
K11984  
U4/U6.U5 tri-snRNP-associated protein 1
K12848  
U4/U6.U5 tri-snRNP component SNU23
K12849  
pre-mRNA-splicing factor 38A
K12850  
pre-mRNA-splicing factor 38B
K12851  
pre-mRNA-splicing factor 38
K12852  
116 kDa U5 small nuclear ribonucleoprotein component
K12853  
114 kDa U5 small nuclear ribonucleoprotein component
K12854  
pre-mRNA-splicing helicase BRR2 [EC:3.6.4.13]
K12855  
pre-mRNA-processing factor 6
K12856  
pre-mRNA-processing factor 8
K12857  
Prp8 binding protein
K12858  
ATP-dependent RNA helicase DDX23/PRP28 [EC:3.6.4.13]
K12859  
U5 snRNP protein, DIM1 family
K10599  
pre-mRNA-processing factor 19 [EC:6.3.2.19]
K12860  
pre-mRNA-splicing factor CDC5/CEF1
K12861  
pre-mRNA-splicing factor SPF27
K12862  
pleiotropic regulator 1
K12863  
protein CWC15
K12864  
beta-catenin-like protein 1
K03283  
heat shock 70kDa protein 1/8
K12865  
polyglutamine-binding protein 1
K12866  
WW domain-binding protein 11
K06063  
SNW domain-containing protein 1
K12867  
pre-mRNA-splicing factor SYF1
K12868  
pre-mRNA-splicing factor SYF2
K12869  
crooked neck
K12870  
pre-mRNA-splicing factor ISY1
K12733  
peptidyl-prolyl cis-trans isomerase-like 1 [EC:5.2.1.8]
K09564  
peptidyl-prolyl isomerase E (cyclophilin E) [EC:5.2.1.8]
K12871  
coiled-coil domain-containing protein 12
K12872  
pre-mRNA-splicing factor RBM22/SLT11
K12873  
bud site selection protein 31
K12874  
intron-binding protein aquarius
K12875  
apoptotic chromatin condensation inducer in the nucleus
K13025  
ATP-dependent RNA helicase [EC:3.6.4.13]
K12876  
RNA-binding protein 8A
K12877  
protein mago nashi
K12878  
THO complex subunit 1
K12879  
THO complex subunit 2
K12880  
THO complex subunit 3
K12881  
THO complex subunit 4
K12882  
nuclear cap-binding protein subunit 1
K12883  
nuclear cap-binding protein subunit 2
K12741  
heterogeneous nuclear ribonucleoprotein A1/A3
K12884  
heterogeneous nuclear ribonucleoprotein C1/C2
K12885  
heterogeneous nuclear ribonucleoprotein G
K12886  
heterogeneous nuclear ribonucleoprotein K
K12887  
heterogeneous nuclear ribonucleoprotein M
K12888  
heterogeneous nuclear ribonucleoprotein U
K12889  
poly(rC)-binding protein 1
K12890  
splicing factor, arginine/serine-rich 1/9
K12891  
splicing factor, arginine/serine-rich 2
K12892  
splicing factor, arginine/serine-rich 3
K12893  
splicing factor, arginine/serine-rich 4/5/6
K12896  
splicing factor, arginine/serine-rich 7
K12897  
transformer-2 protein
K12900  
FUS-interacting serine-arginine-rich protein 1
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)

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