KEGG   PATHWAY: ko03320Help
Entry
ko03320                     Pathway                                

Name
PPAR signaling pathway
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
PPAR signaling pathway
ko03320

All organismsOrtholog table
Disease
H00151  
Cerebrotendinous xanthomatosis
H00154  
Hyperlipoproteinemia, type I
H00157  
Hyperlipoproteinemia, type V
H00407  
Peroxisomal beta-oxidation enzyme deficiency
H00409  
Type II diabetes mellitus
H00420  
Familial partial lipodystrophy (FPL)
H00552  
Glycerol kinase deficiency (GKD)
H00874  
Leukoencephalopathy with dystonia and motor neuropathy
H00930  
Hypoalphalipoproteinemia
H00967  
Adiponectin deficiency
H01108  
CD36 deficiency
H01199  
Hyperalphalipoproteinemia
Orthology
K06259  
CD36 antigen
K08745  
solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
K08746  
solute carrier family 27 (fatty acid transporter), member 2 [EC:6.2.1.3 6.2.1.-]
K08748  
solute carrier family 27 (fatty acid transporter), member 5 [EC:6.2.1.7]
K08749  
solute carrier family 27 (fatty acid transporter), member 6
K08750  
fatty acid-binding protein 1, liver
K08751  
fatty acid-binding protein 2, intestinal
K08752  
fatty acid-binding protein 3, muscle and heart
K08753  
fatty acid-binding protein 4, adipocyte
K08754  
fatty acid-binding protein 5, epidermal
K08755  
fatty acid-binding protein 6, ileal (gastrotropin)
K08756  
fatty acid-binding protein 7, brain
K07294  
peroxisome proliferator-activated receptor alpha
K08524  
retinoid X receptor alpha
K08525  
retinoid X receptor beta
K08526  
retinoid X receptor gamma
K04504  
peroxisome proliferator-activated receptor delta
K08530  
peroxisome proliferator-activated receptor gamma
K08757  
apolipoprotein A-I
K08758  
apolipoprotein A-II
K08759  
apolipoprotein C-III
K09025  
apolipoprotein A-V
K08761  
phospholipid transfer protein
K10226  
fatty acid desaturase 2 (delta-6 desaturase) [EC:1.14.19.-]
K00507  
stearoyl-CoA desaturase (delta-9 desaturase) [EC:1.14.19.1]
K00489  
cholesterol 7alpha-monooxygenase [EC:1.14.13.17]
K07431  
sterol 12-alpha-hydroxylase [EC:1.14.13.96 1.14.13.95]
K08536  
liver X receptor alpha
K00488  
cholestanetriol 26-monooxygenase [EC:1.14.13.15]
K08762  
diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein)
K01059  
lipoprotein lipase [EC:3.1.1.34]
K01897  
long-chain acyl-CoA synthetase [EC:6.2.1.3]
K15013  
long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K08763  
oxidised low-density lipoprotein receptor 1
K07514  
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:5.3.3.8 1.1.1.35 4.2.1.17]
K07425  
alkane 1-monooxygenase [EC:1.14.15.3]
K07513  
acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
K08764  
sterol carrier protein 2 [EC:2.3.1.176]
K00232  
acyl-CoA oxidase [EC:1.3.3.6]
K10214  
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3]
K08765  
carnitine O-palmitoyltransferase 1 [EC:2.3.1.21]
K08766  
carnitine O-palmitoyltransferase 2 [EC:2.3.1.21]
K00255  
long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]
K00249  
acyl-CoA dehydrogenase [EC:1.3.8.7]
K08767  
angiopoietin-like 4
K06086  
sorbin and SH3 domain containing 1
K08768  
perilipin
K07296  
adiponectin
K01388  
matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K08769  
solute carrier family 25 (mitochondrial uncoupling protein), member 7
K06272  
integrin-linked kinase [EC:2.7.11.1]
K06276  
3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K08770  
ubiquitin C
K01596  
phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K00864  
glycerol kinase [EC:2.7.1.30]
K08771  
aquaporin-7
Compound
C02165  
Leukotriene B4
C14762  
13(S)-HODE
C14767  
9(S)-HODE
C14776  
8(S)-HETE
C15493  
9-cis-Retinoic acid
Reference
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
Reference
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
Reference
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
Reference
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
Reference
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
Reference
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
Reference
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
Reference
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)

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