KEGG   PATHWAY: ko03320Help
Entry
ko03320                     Pathway                                

Name
PPAR signaling pathway
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
ko03320  PPAR signaling pathway
ko03320

Ortholog table
Disease
H00151  Cerebrotendinous xanthomatosis
H00154  Hyperlipoproteinemia, type I
H00157  Hyperlipoproteinemia, type V
H00407  Peroxisomal beta-oxidation enzyme deficiency
H00409  Type II diabetes mellitus
H00420  Familial partial lipodystrophy (FPL)
H00552  Chromosome Xp21 deletion syndrome
H00874  Leukoencephalopathy with dystonia and motor neuropathy
H00930  Hypoalphalipoproteinemia
H00967  Adiponectin deficiency
H01108  CD36 deficiency
H01199  Hyperalphalipoproteinemia
H02013  Glycerol kinase deficiency
Orthology
K06259  CD36 antigen
K08745  solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
K08746  solute carrier family 27 (fatty acid transporter), member 2 [EC:6.2.1.3 6.2.1.-]
K08748  solute carrier family 27 (fatty acid transporter), member 5 [EC:6.2.1.7]
K08749  solute carrier family 27 (fatty acid transporter), member 6
K08750  fatty acid-binding protein 1, liver
K08751  fatty acid-binding protein 2, intestinal
K08752  fatty acid-binding protein 3, muscle and heart
K08753  fatty acid-binding protein 4, adipocyte
K08754  fatty acid-binding protein 5, epidermal
K08755  fatty acid-binding protein 6, ileal (gastrotropin)
K08756  fatty acid-binding protein 7, brain
K07294  peroxisome proliferator-activated receptor alpha
K08524  retinoid X receptor alpha
K08525  retinoid X receptor beta
K08526  retinoid X receptor gamma
K04504  peroxisome proliferator-activated receptor delta
K08530  peroxisome proliferator-activated receptor gamma
K08757  apolipoprotein A-I
K08758  apolipoprotein A-II
K08759  apolipoprotein C-III
K09025  apolipoprotein A-V
K08761  phospholipid transfer protein
K10226  acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]
K00507  stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
K00489  cholesterol 7alpha-monooxygenase [EC:1.14.14.23]
K07431  sterol 12-alpha-hydroxylase [EC:1.14.13.96 1.14.18.8]
K08536  liver X receptor alpha
K00488  cholestanetriol 26-monooxygenase [EC:1.14.15.15]
K08762  diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein)
K01059  lipoprotein lipase [EC:3.1.1.34]
K01897  long-chain acyl-CoA synthetase [EC:6.2.1.3]
K15013  long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K08763  oxidised low-density lipoprotein receptor 1
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:5.3.3.8 1.1.1.35 4.2.1.17]
K07425  alkane 1-monooxygenase [EC:1.14.15.3]
K07513  acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
K08764  sterol carrier protein 2 [EC:2.3.1.176]
K00232  acyl-CoA oxidase [EC:1.3.3.6]
K10214  3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3]
K08765  carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]
K19523  carnitine O-palmitoyltransferase 1, muscle isoform [EC:2.3.1.21]
K19524  carnitine O-palmitoyltransferase 1, brain isoform [EC:2.3.1.21]
K08766  carnitine O-palmitoyltransferase 2 [EC:2.3.1.21]
K00255  long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]
K00249  acyl-CoA dehydrogenase [EC:1.3.8.7]
K08767  angiopoietin-like 4
K06086  sorbin and SH3 domain containing 1
K08768  perilipin-1
K17284  perilipin-2
K20254  perilipin-4
K20255  perilipin-5
K07296  adiponectin
K01388  matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K08769  solute carrier family 25 (mitochondrial uncoupling protein), member 7
K06272  integrin-linked kinase [EC:2.7.11.1]
K06276  3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K08770  ubiquitin C
K01596  phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K00864  glycerol kinase [EC:2.7.1.30]
K08771  aquaporin-7
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249

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