KEGG   PATHWAY: ko04060Help
Entry
ko04060                     Pathway                                

Name
Cytokine-cytokine receptor interaction
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Cytokine-cytokine receptor interaction
ko04060

All organismsOrtholog table
Disease
H00097  
Chemokine receptor defect
H00227  
Congenital amegakaryocytic thrombocytopenia (CAMT)
H00344  
Leprosy
H00408  
Type I diabetes mellitus
H00609  
46,XY disorders of sex development (Other)
H00632  
Heterotaxy
H00651  
Ectodermal dysplasia
H00800  
Loeys-Dietz syndrome (LDS)
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
H00821  
Macular degeneration
H00912  
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
H00935  
Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
H01023  
Juvenile polyposis syndrome
H01024  
Hereditary mixed polyposis syndrome
H01109  
Chronic mucocutaneous candidiasis (CMC)
H01122  
Pulmonary alveolar proteinosis (PAP)
H01217  
Primary localized cutaneous amyloidosis (PLCA)
H01227  
Inflammatory bowel disease
Orthology
K10029  
platelet basic protein
K10030  
interleukin 8
K05416  
C-X-C motif chemokine 9
K12671  
C-X-C motif chemokine 10
K12672  
C-X-C motif chemokine 11
K10031  
C-X-C motif chemokine 12
K10032  
C-X-C motif chemokine 13
K10035  
C-X-C motif chemokine 16
K10034  
C-X-C motif chemokine 15
K05407  
platelet factor 4
K10033  
C-X-C motif chemokine 14
K05508  
C-X3-C motif chemokine 1
K14625  
C-C motif chemokine 20
K13072  
C-C motif chemokine 25
K05512  
C-C motif chemokine 19
K16062  
C-C motif chemokine 21
K14624  
C-C motif chemokine 2
K12964  
C-C motif chemokine 4
K05408  
C-C motif chemokine 3
K16595  
C-C motif chemokine 13
K05509  
C-C motif chemokine 7
K12499  
C-C motif chemokine 5
K16596  
C-C motif chemokine 8
K16597  
C-C motif chemokine 11
K05513  
C-C motif chemokine 28
K16598  
C-C motif chemokine 27
K05405  
interleukin 6
K05417  
interleukin 11
K05418  
oncostatin M
K05419  
leukemia inhibitory factor
K05420  
ciliary neurotrophic factor
K05421  
B-cell stimulating factor 3
K05422  
cardiotrophin 1
K05423  
granulocyte colony-stimulating factor
K05424  
leptin
K05430  
interleukin 4
K05435  
interleukin 13
K05406  
interleukin 12A
K05425  
interleukin 12B
K05426  
interleukin 23, alpha subunit p19
K05427  
granulocyte-macrophage colony-stimulating factor
K04736  
interleukin 3
K05428  
interleukin 5
K05429  
interleukin 2
K05431  
interleukin 7
K05432  
interleukin 9
K05433  
interleukin 15
K05434  
interleukin 21
K05436  
thymic stromal lymphopoietin
K05437  
erythropoietin
K05439  
prolactin
K00431  
thyroid peroxidase [EC:1.11.1.8]
K04359  
platelet-derived growth factor subunit A
K17386  
platelet-derived growth factor subunit B
K05448  
vascular endothelial growth factor A
K16858  
vascular endothelial growth factor B
K05449  
vascular endothelial growth factor C/D
K05460  
hepatocyte growth factor
K04357  
epidermal growth factor
K05453  
macrophage colony-stimulating factor 1
K05461  
KIT ligand
K05454  
fms-related tyrosine kinase 3 ligand
K05414  
interferon alpha
K05415  
interferon beta
K05440  
interferon, omega 1
K05441  
interferon, kappa
K05442  
interferon, tau-1
K04687  
interferon gamma
K05443  
interleukin 10
K05445  
interleukin 22
K05446  
interleukin 26
K05478  
tumor necrosis factor ligand superfamily member 15
K04721  
tumor necrosis factor ligand superfamily member 10
K05473  
tumor necrosis factor ligand superfamily member 11
K05474  
tumor necrosis factor ligand superfamily member 12
K03156  
tumor necrosis factor superfamily, member 2
K05468  
lymphotoxin alpha (TNF superfamily, member 1)
K03157  
lymphotoxin beta (TNF superfamily, member 3)
K05477  
tumor necrosis factor ligand superfamily member 14
K04389  
tumor necrosis factor ligand superfamily member 6
K03161  
tumor necrosis factor ligand superfamily member 5
K05470  
tumor necrosis factor ligand superfamily member 7
K05471  
tumor necrosis factor ligand superfamily member 8
K05472  
tumor necrosis factor ligand superfamily member 9
K05469  
tumor necrosis factor ligand superfamily member 4
K05479  
tumor necrosis factor ligand superfamily member 18
K05475  
tumor necrosis factor ligand superfamily member 13
K05476  
tumor necrosis factor ligand superfamily member 13B
K05480  
ectodysplasin-A
K13375  
transforming growth factor beta-1
K13376  
transforming growth factor beta-2
K13377  
transforming growth factor beta-3
K04665  
anti-mullerian hormone
K16621  
bone morphogenetic protein 7
K05489  
interleukin 17
K05490  
interleukin 17B
K05493  
interleukin 17E
K04383  
interleukin 1 alpha
K04519  
interleukin 1 beta
K05482  
interleukin 18
K05050  
interleukin 8 receptor beta
K04175  
interleukin 8 receptor alpha
K04188  
C-X-C chemokine receptor type 3
K04189  
C-X-C chemokine receptor type 4
K04190  
C-X-C chemokine receptor type 5
K04191  
C-X-C chemokine receptor type 6
K04304  
C-X-C chemokine receptor type 7
K04193  
XC chemokine receptor 1
K04192  
CX3C chemokine receptor 1
K04183  
C-C chemokine receptor type 8
K04181  
C-C chemokine receptor type 6
K04184  
C-C chemokine receptor type 9
K04179  
C-C chemokine receptor type 4
K04182  
C-C chemokine receptor type 7
K04177  
C-C chemokine receptor type 2
K04180  
C-C chemokine receptor type 5
K04176  
C-C chemokine receptor type 1
K04178  
C-C chemokine receptor type 3
K04185  
C-C chemokine receptor type 10
K05055  
interleukin 6 receptor
K05060  
interleukin 6 signal transducer
K05056  
interleukin 11 receptor alpha
K05058  
leukemia inhibitory factor receptor
K05057  
oncostatin M receptor
K05059  
ciliary neurotrophic factor receptor
K05061  
granulocyte colony-stimulating factor receptor
K05062  
leptin receptor
K05071  
interleukin 4 receptor
K05076  
interleukin 13 receptor alpha-1
K05063  
interleukin 12 receptor beta-1
K05064  
interleukin 12 receptor beta-2
K05065  
interleukin 23 receptor
K05066  
granulocyte-macrophage colony-stimulating factor receptor alpha
K04738  
cytokine receptor common subunit beta
K04737  
interleukin 3 receptor alpha
K05067  
interleukin 5 receptor alpha
K05068  
interleukin 2 receptor alpha
K05069  
interleukin 2 receptor beta
K05070  
interleukin 2 receptor gamma
K05072  
interleukin 7 receptor
K05073  
interleukin 9 receptor
K05074  
interleukin 15 receptor alpha
K05075  
interleukin 21 receptor
K05078  
thymic stromal-derived lymphopoietin receptor
K05079  
erythropoietin receptor
K05080  
growth hormone receptor
K05081  
prolactin receptor
K05082  
thrombopoietin receptor
K04363  
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089  
platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05096  
FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K05098  
kinase insert domain protein receptor [EC:2.7.10.1]
K05097  
FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K05099  
proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04361  
epidermal growth factor receptor [EC:2.7.10.1]
K05090  
macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05091  
proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05092  
fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05130  
interferon receptor 1
K05131  
interferon receptor 2
K05132  
interferon gamma receptor 1
K05133  
interferon gamma receptor 2
K05134  
interleukin 10 receptor alpha
K05135  
interleukin 10 receptor beta
K05136  
interleukin 20 receptor alpha
K05137  
interleukin 20 receptor beta
K05138  
interleukin 22 receptor alpha 1
K05139  
interleukin 22 receptor alpha 2
K05140  
interleukin 28 receptor alpha
K05148  
tumor necrosis factor receptor superfamily member 11B
K05147  
tumor necrosis factor receptor superfamily member 11A
K05160  
tumor necrosis factor receptor superfamily member 25
K05149  
tumor necrosis factor receptor superfamily member 12A
K05157  
tumor necrosis factor receptor superfamily member 21
K02583  
nerve growth factor receptor (TNFR superfamily member 16)
K05141  
tumor necrosis factor receptor superfamily member 1B
K03158  
tumor necrosis factor receptor superfamily member 1A
K03159  
lymphotoxin beta receptor TNFR superfamily member 3
K05152  
tumor necrosis factor receptor superfamily member 14
K05143  
tumor necrosis factor receptor superfamily member 6B
K04390  
tumor necrosis factor receptor superfamily member 6
K03160  
tumor necrosis factor receptor superfamily member 5
K05144  
tumor necrosis factor receptor superfamily member 7
K05145  
tumor necrosis factor receptor superfamily member 8
K05146  
tumor necrosis factor receptor superfamily member 9
K05142  
tumor necrosis factor receptor superfamily member 4
K05154  
tumor necrosis factor receptor superfamily member 18
K05153  
tumor necrosis factor receptor superfamily member 17
K05150  
tumor necrosis factor receptor superfamily member 13B
K05151  
tumor necrosis factor receptor superfamily member 13C
K05162  
tumor necrosis factor receptor superfamily member EDAR
K05163  
tumor necrosis factor receptor superfamily member 27
K05155  
tumor necrosis factor receptor superfamily member 19
K05156  
tumor necrosis factor receptor superfamily member 19-like
K04388  
TGF-beta receptor type-2 [EC:2.7.11.30]
K04674  
TGF-beta receptor type-1 [EC:2.7.11.30]
K04670  
activin receptor type-2A [EC:2.7.11.30]
K13596  
activin receptor type-2B [EC:2.7.11.30]
K04675  
activin receptor type-1 [EC:2.7.11.30]
K13567  
activin receptor type-1B [EC:2.7.11.30]
K04672  
anti-mullerian hormone receptor type-2 [EC:2.7.11.30]
K04671  
bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K04673  
bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
K13578  
bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
K05164  
interleukin 17 receptor
K05165  
interleukin 17 receptor B
K04386  
interleukin 1 receptor type I
K04723  
interleukin 1 receptor accessory protein
K04387  
interleukin 1 receptor type II
K05173  
interleukin 18 receptor 1
K05174  
interleukin 18 receptor accessory protein
Reference
  Authors
Oppenheim JJ, Feldman M (ed).
  Title
Cytokine Reference
  Journal
Academic Press (2001)
Reference
  Authors
Thomson AW, Lotze MT (ed).
  Title
The Cytokine Handbook (Fourth edition)
  Journal
Academic Press (2003)
Reference
  Authors
Zlotnik A, Yoshie O.
  Title
Chemokines: a new classification system and their role in immunity.
  Journal
Immunity 12:121-7 (2000)
Reference
  Authors
Ozaki K, Leonard WJ.
  Title
Cytokine and cytokine receptor pleiotropy and redundancy.
  Journal
J Biol Chem 277:29355-8 (2002)
Reference
  Authors
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW.
  Title
Signaling through the JAK/STAT pathway, recent advances and future challenges.
  Journal
Gene 285:1-24 (2002)
Reference
  Authors
Li X, Eriksson U.
  Title
Novel PDGF family members: PDGF-C and PDGF-D.
  Journal
Cytokine Growth Factor Rev 14:91-8 (2003)
Reference
  Authors
Li X, Eriksson U.
  Title
Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.
  Journal
Int J Biochem Cell Biol 33:421-6 (2001)
Reference
  Authors
Zachary I, Gliki G.
  Title
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.
  Journal
Cardiovasc Res 49:568-81 (2001)
Reference
  Authors
Dey A, She H, Kim L, Boruch A, Guris DL, Carlberg K, Sebti SM, Woodley DT, Imamoto A, Li W.
  Title
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.
  Journal
Mol Biol Cell 11:3835-48 (2000)
Reference
  Authors
Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB.
  Title
Interleukin-10 and related cytokines and receptors.
  Journal
Annu Rev Immunol 22:929-79 (2004)
Reference
  Authors
Bodmer JL, Schneider P, Tschopp J.
  Title
The molecular architecture of the TNF superfamily.
  Journal
Trends Biochem Sci 27:19-26 (2002)
Reference
PMID:9395284
  Authors
Derynck R, Feng XH.
  Title
TGF-beta receptor signaling.
  Journal
Biochim Biophys Acta 1333:F105-50 (1997)
Reference
PMID:7791754
  Authors
Liu F, Ventura F, Doody J, Massague J.
  Title
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
  Journal
Mol Cell Biol 15:3479-86 (1995)
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)
Reference
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
Reference
  Authors
Moseley TA, Haudenschild DR, Rose L, Reddi AH.
  Title
Interleukin-17 family and IL-17 receptors.
  Journal
Cytokine Growth Factor Rev 14:155-74 (2003)
Reference
  Authors
Martin MU, Wesche H.
  Title
Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family.
  Journal
Biochim Biophys Acta 1592:265-80 (2002)
Reference
PMID:9862719
  Authors
Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU.
  Title
The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.
  Journal
J Immunol 161:6871-7 (1998)

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