KEGG   PATHWAY: ko04060Help
Entry
ko04060                     Pathway                                

Name
Cytokine-cytokine receptor interaction
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ko04060  Cytokine-cytokine receptor interaction
ko04060

Ortholog table
Disease
H00097  Chemokine receptor defect
H00227  Congenital amegakaryocytic thrombocytopenia (CAMT)
H00286  Crohn's disease
H00344  Leprosy
H00408  Type I diabetes mellitus
H00609  46,XY disorders of sex development (Other)
H00632  Heterotaxy
H00651  Ectodermal dysplasia
H00800  Loeys-Dietz syndrome (LDS)
H00801  Familial thoracic aortic aneurysm and dissection (TAAD)
H00912  Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
H00935  Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
H01023  Juvenile polyposis syndrome
H01024  Hereditary mixed polyposis syndrome
H01109  Chronic mucocutaneous candidiasis (CMC)
H01122  Congenital pulmonary alveolar proteinosis
H01217  Primary localized cutaneous amyloidosis (PLCA)
H01227  Inflammatory bowel disease (IBD)
H01466  Ulcerative colitis (UC)
H01479  Castleman disease
H01672  Juvenile idiopathic arthritis (JIA)
H02037  Laron syndrome
H02039  Kowarski syndrome
H02059  Leptin deficiency
H02060  Leptin receptor deficiency
Orthology
K10029  platelet basic protein
K10030  interleukin 8
K05416  C-X-C motif chemokine 9
K12671  C-X-C motif chemokine 10
K12672  C-X-C motif chemokine 11
K10031  C-X-C motif chemokine 12
K10032  C-X-C motif chemokine 13
K10035  C-X-C motif chemokine 16
K10034  C-X-C motif chemokine 15
K05407  platelet factor 4
K10033  C-X-C motif chemokine 14
K05508  C-X3-C motif chemokine 1
K05514  C-C motif chemokine 1
K14625  C-C motif chemokine 20
K13072  C-C motif chemokine 25
K21083  C-C motif chemokine 17
K21095  C-C motif chemokine 22
K05512  C-C motif chemokine 19
K16062  C-C motif chemokine 21
K14624  C-C motif chemokine 2
K12964  C-C motif chemokine 4
K05408  C-C motif chemokine 3
K16595  C-C motif chemokine 13
K05509  C-C motif chemokine 7
K12499  C-C motif chemokine 5
K21092  C-C motif chemokine 14
K21093  C-C motif chemokine 16
K16596  C-C motif chemokine 8
K16597  C-C motif chemokine 11
K21097  C-C motif chemokine 24
K21096  C-C motif chemokine 26
K05513  C-C motif chemokine 28
K16598  C-C motif chemokine 27
K21094  C-C motif chemokine 18
K05405  interleukin 6
K05417  interleukin 11
K05418  oncostatin M
K05419  leukemia inhibitory factor
K05420  ciliary neurotrophic factor
K05421  B-cell stimulating factor 3
K05422  cardiotrophin 1
K05423  granulocyte colony-stimulating factor
K05424  leptin
K05430  interleukin 4
K05435  interleukin 13
K05406  interleukin 12A
K05425  interleukin 12B
K05426  interleukin 23 subunit alpha
K05427  granulocyte-macrophage colony-stimulating factor
K04736  interleukin 3
K05428  interleukin 5
K05429  interleukin 2
K05431  interleukin 7
K05432  interleukin 9
K05433  interleukin 15
K05434  interleukin 21
K05436  thymic stromal lymphopoietin
K05437  erythropoietin
K05439  prolactin
K06854  thrombopoietin
K04359  platelet-derived growth factor subunit A
K17386  platelet-derived growth factor subunit B
K05448  vascular endothelial growth factor A
K16858  vascular endothelial growth factor B
K05449  vascular endothelial growth factor C/D
K05460  hepatocyte growth factor
K04357  epidermal growth factor
K05453  macrophage colony-stimulating factor 1
K05461  KIT ligand
K05454  fms-related tyrosine kinase 3 ligand
K05414  interferon alpha
K05415  interferon beta
K05440  interferon omega
K05441  interferon kappa
K05442  interferon epsilon
K04687  interferon gamma
K05443  interleukin 10
K05445  interleukin 22
K05446  interleukin 26
K05478  tumor necrosis factor ligand superfamily member 15
K04721  tumor necrosis factor ligand superfamily member 10
K05473  tumor necrosis factor ligand superfamily member 11
K05474  tumor necrosis factor ligand superfamily member 12
K03156  tumor necrosis factor superfamily, member 2
K05468  lymphotoxin alpha (TNF superfamily, member 1)
K03157  lymphotoxin beta (TNF superfamily, member 3)
K05477  tumor necrosis factor ligand superfamily member 14
K04389  tumor necrosis factor ligand superfamily member 6
K03161  tumor necrosis factor ligand superfamily member 5
K05470  tumor necrosis factor ligand superfamily member 7
K05471  tumor necrosis factor ligand superfamily member 8
K05472  tumor necrosis factor ligand superfamily member 9
K05469  tumor necrosis factor ligand superfamily member 4
K05479  tumor necrosis factor ligand superfamily member 18
K05475  tumor necrosis factor ligand superfamily member 13
K05476  tumor necrosis factor ligand superfamily member 13B
K05480  ectodysplasin-A
K13375  transforming growth factor beta-1
K13376  transforming growth factor beta-2
K13377  transforming growth factor beta-3
K04665  anti-mullerian hormone
K21283  bone morphogenetic protein 2
K16621  bone morphogenetic protein 7
K04664  growth differentiation factor 5
K04383  interleukin 1 alpha
K04519  interleukin 1 beta
K05482  interleukin 18
K05493  interleukin 17E
K05489  interleukin 17A
K05494  interleukin 17F
K05491  interleukin 17C
K05490  interleukin 17B
K05492  interleukin 17D
K05050  C-X-C chemokine receptor type 2
K04175  C-X-C chemokine receptor type 1
K04188  C-X-C chemokine receptor type 3
K04189  C-X-C chemokine receptor type 4
K04190  C-X-C chemokine receptor type 5
K04191  C-X-C chemokine receptor type 6
K04304  C-X-C chemokine receptor type 7
K04193  XC chemokine receptor 1
K04192  CX3C chemokine receptor 1
K04183  C-C chemokine receptor type 8
K04181  C-C chemokine receptor type 6
K04184  C-C chemokine receptor type 9
K04179  C-C chemokine receptor type 4
K04182  C-C chemokine receptor type 7
K04177  C-C chemokine receptor type 2
K04180  C-C chemokine receptor type 5
K04176  C-C chemokine receptor type 1
K04178  C-C chemokine receptor type 3
K04185  C-C chemokine receptor type 10
K05055  interleukin 6 receptor
K05060  interleukin 6 signal transducer
K05056  interleukin 11 receptor alpha
K05058  leukemia inhibitory factor receptor
K05057  oncostatin M receptor
K05059  ciliary neurotrophic factor receptor
K05061  granulocyte colony-stimulating factor receptor
K05062  leptin receptor
K05071  interleukin 4 receptor
K05076  interleukin 13 receptor alpha-1
K05063  interleukin 12 receptor beta-1
K05064  interleukin 12 receptor beta-2
K05065  interleukin 23 receptor
K05066  granulocyte-macrophage colony-stimulating factor receptor alpha
K04738  cytokine receptor common subunit beta
K04737  interleukin 3 receptor alpha
K05067  interleukin 5 receptor alpha
K05068  interleukin 2 receptor alpha
K05069  interleukin 2 receptor beta
K05070  interleukin 2 receptor gamma
K05072  interleukin 7 receptor
K05073  interleukin 9 receptor
K05074  interleukin 15 receptor alpha
K05075  interleukin 21 receptor
K05078  thymic stromal-derived lymphopoietin receptor
K05079  erythropoietin receptor
K05080  growth hormone receptor
K05081  prolactin receptor
K05082  thrombopoietin receptor
K04363  platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089  platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05096  FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K05098  kinase insert domain protein receptor [EC:2.7.10.1]
K05097  FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04361  epidermal growth factor receptor [EC:2.7.10.1]
K05090  macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05091  proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05092  fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05130  interferon receptor 1
K05131  interferon receptor 2
K05132  interferon gamma receptor 1
K05133  interferon gamma receptor 2
K05134  interleukin 10 receptor alpha
K05135  interleukin 10 receptor beta
K05136  interleukin 20 receptor alpha
K05137  interleukin 20 receptor beta
K05138  interleukin 22 receptor alpha 1
K05139  interleukin 22 receptor alpha 2
K05140  interferon lambda receptor 1
K05148  tumor necrosis factor receptor superfamily member 11B
K05147  tumor necrosis factor receptor superfamily member 11A
K05160  tumor necrosis factor receptor superfamily member 25
K05149  tumor necrosis factor receptor superfamily member 12A
K05157  tumor necrosis factor receptor superfamily member 21
K02583  nerve growth factor receptor (TNFR superfamily member 16)
K05141  tumor necrosis factor receptor superfamily member 1B
K03158  tumor necrosis factor receptor superfamily member 1A
K03159  lymphotoxin beta receptor TNFR superfamily member 3
K05152  tumor necrosis factor receptor superfamily member 14
K05143  tumor necrosis factor receptor superfamily member 6B
K04390  tumor necrosis factor receptor superfamily member 6
K03160  tumor necrosis factor receptor superfamily member 5
K05144  tumor necrosis factor receptor superfamily member 7
K05145  tumor necrosis factor receptor superfamily member 8
K05146  tumor necrosis factor receptor superfamily member 9
K05142  tumor necrosis factor receptor superfamily member 4
K05154  tumor necrosis factor receptor superfamily member 18
K05153  tumor necrosis factor receptor superfamily member 17
K05150  tumor necrosis factor receptor superfamily member 13B
K05151  tumor necrosis factor receptor superfamily member 13C
K05162  tumor necrosis factor receptor superfamily member EDAR
K05163  tumor necrosis factor receptor superfamily member 27
K05155  tumor necrosis factor receptor superfamily member 19
K05156  tumor necrosis factor receptor superfamily member 19-like
K04388  TGF-beta receptor type-2 [EC:2.7.11.30]
K04674  TGF-beta receptor type-1 [EC:2.7.11.30]
K04670  activin receptor type-2A [EC:2.7.11.30]
K13596  activin receptor type-2B [EC:2.7.11.30]
K04675  activin receptor type-1 [EC:2.7.11.30]
K13567  activin receptor type-1B [EC:2.7.11.30]
K04672  anti-mullerian hormone receptor type-2 [EC:2.7.11.30]
K04671  bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K04673  bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
K13578  bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
K04386  interleukin 1 receptor type I
K04723  interleukin 1 receptor accessory protein
K04387  interleukin 1 receptor type II
K05173  interleukin 18 receptor 1
K05174  interleukin 18 receptor accessory protein
K05164  interleukin 17 receptor A
K05165  interleukin 17 receptor B
K05166  interleukin 17 receptor C
K05168  interleukin 17 receptor E
Reference
  Authors
Oppenheim JJ, Feldman M (ed).
  Title
Cytokine Reference
  Journal
Academic Press (2001)
Reference
  Authors
Thomson AW, Lotze MT (ed).
  Title
The Cytokine Handbook (Fourth edition)
  Journal
Academic Press (2003)
Reference
  Authors
Zlotnik A, Yoshie O.
  Title
Chemokines: a new classification system and their role in immunity.
  Journal
Immunity 12:121-7 (2000)
DOI:10.1016/S1074-7613(00)80165-X
Reference
  Authors
Ozaki K, Leonard WJ.
  Title
Cytokine and cytokine receptor pleiotropy and redundancy.
  Journal
J Biol Chem 277:29355-8 (2002)
DOI:10.1074/jbc.R200003200
Reference
  Authors
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW.
  Title
Signaling through the JAK/STAT pathway, recent advances and future challenges.
  Journal
Gene 285:1-24 (2002)
DOI:10.1016/S0378-1119(02)00398-0
Reference
  Authors
Li X, Eriksson U.
  Title
Novel PDGF family members: PDGF-C and PDGF-D.
  Journal
Cytokine Growth Factor Rev 14:91-8 (2003)
DOI:10.1016/S1359-6101(02)00090-4
Reference
  Authors
Li X, Eriksson U.
  Title
Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.
  Journal
Int J Biochem Cell Biol 33:421-6 (2001)
DOI:10.1016/S1357-2725(01)00027-9
Reference
  Authors
Zachary I, Gliki G.
  Title
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.
  Journal
Cardiovasc Res 49:568-81 (2001)
DOI:10.1016/S0008-6363(00)00268-6
Reference
  Authors
Dey A, She H, Kim L, Boruch A, Guris DL, Carlberg K, Sebti SM, Woodley DT, Imamoto A, Li W.
  Title
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.
  Journal
Mol Biol Cell 11:3835-48 (2000)
DOI:10.1091/mbc.11.11.3835
Reference
  Authors
Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB.
  Title
Interleukin-10 and related cytokines and receptors.
  Journal
Annu Rev Immunol 22:929-79 (2004)
DOI:10.1146/annurev.immunol.22.012703.104622
Reference
  Authors
Bodmer JL, Schneider P, Tschopp J.
  Title
The molecular architecture of the TNF superfamily.
  Journal
Trends Biochem Sci 27:19-26 (2002)
DOI:10.1016/S0968-0004(01)01995-8
Reference
PMID:9395284
  Authors
Derynck R, Feng XH.
  Title
TGF-beta receptor signaling.
  Journal
Biochim Biophys Acta 1333:F105-50 (1997)
DOI:10.1016/S0304-419X(97)00017-6
Reference
PMID:7791754
  Authors
Liu F, Ventura F, Doody J, Massague J.
  Title
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
  Journal
Mol Cell Biol 15:3479-86 (1995)
DOI:10.1128/MCB.15.7.3479
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)
DOI:10.1146/annurev.biochem.67.1.753
Reference
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
  Authors
Moseley TA, Haudenschild DR, Rose L, Reddi AH.
  Title
Interleukin-17 family and IL-17 receptors.
  Journal
Cytokine Growth Factor Rev 14:155-74 (2003)
DOI:10.1016/S1359-6101(03)00002-9
Reference
  Authors
Martin MU, Wesche H.
  Title
Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family.
  Journal
Biochim Biophys Acta 1592:265-80 (2002)
DOI:10.1016/S0167-4889(02)00320-8
Reference
PMID:9862719
  Authors
Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU.
  Title
The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.
  Journal
J Immunol 161:6871-7 (1998)

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