| Entry |
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| Name |
Cell cycle - Caulobacter
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| Description |
Cell cycle progression of Caulobacter crescentus is implemented by an elaborate transcriptional regulatory network. During the life cycle, Caulobacter divides asymmetrically producing two distinct cell types with specialized development programs. The sessile stalked cell immediately initiates a new round of division cycle, whereas the motile swarmer cell remains in the G1 phase for a defined interval before differentiating into the stalked cell and entering into the S phase. The division process is centered around three master regulator proteins, DnaA, GcrA, and CtrA. DnaA and GcrA together drive the synthesis of proteins needed to complete DNA replication. CtrA controls the transcription of a diverse group of genes, which are required for essential morphological, metabolic, and cell cycle events.
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| Class |
Cellular Processes; Cell growth and death
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| Pathway map |
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| Module |
| PleC-PleD (cell fate control) two-component regulatory system [PATH: ko04112] | | CckA-CtrA/CpdR (cell cycle control) two-component regulatory system [PATH: ko04112] |
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| Other DBs |
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| Orthology |
| chromosomal replication initiator protein | | | | GcrA cell cycle regulator | | two-component system, cell cycle response regulator CtrA | | | | | | cell division protein FtsZ | | cell division protein FtsQ | | cell division protein FtsA | | cell division protein FtsW | | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC: 2.4.1.227] | | holdfast attachment protein HfaA | | holdfast attachment protein HfaB | | localization factor PodJL | | aspartyl protease family protein | | regulator of sigma E protease [EC:3.4.24.-] | | two-component system, cell cycle sensor histidine kinase PleC [EC: 2.7.13.3] | | two-component system, cell cycle sensor histidine kinase DivJ [EC: 2.7.13.3] | | two-component system, cell cycle response regulator DivK | | two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC: 2.7.13.3] | | histidine phosphotransferase ChpT | | two-component system, cell cycle response regulator CpdR | | ATP-dependent Clp protease ATP-binding subunit ClpX | | ATP-dependent Clp protease, protease subunit [EC: 3.4.21.92] | | two-component system, cell cycle response regulator | | diguanylate cyclase | | two-component system, cell cycle response regulator PopA | | regulator of CtrA degradation | | c-di-GMP-specific phosphodiesterase [EC: 3.1.4.52] | | cyclic-di-GMP phosphodiesterase, flagellum assembly factor TipF | | pilus assembly protein Flp/PilA |
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| Compound |
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| Reference |
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| Authors |
Shen X, Collier J, Dill D, Shapiro L, Horowitz M, McAdams HH |
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| Title |
Architecture and inherent robustness of a bacterial cell-cycle control system. |
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| Journal |
Proc Natl Acad Sci U S A 105:11340-5 (2008) |
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| Reference |
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| Authors |
Curtis PD, Brun YV |
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| Title |
Getting in the loop: regulation of development in Caulobacter crescentus. |
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| Journal |
Microbiol Mol Biol Rev 74:13-41 (2010) |
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| Reference |
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| Authors |
Skerker JM, Laub MT |
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| Title |
Cell-cycle progression and the generation of asymmetry in Caulobacter crescentus. |
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| Journal |
Nat Rev Microbiol 2:325-37 (2004) |
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| Reference |
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| Authors |
Jenal U, Galperin MY |
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| Title |
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics. |
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| Journal |
Curr Opin Microbiol 12:152-60 (2009) |
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| Reference |
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| Authors |
Thanbichler M |
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| Title |
Spatial regulation in Caulobacter crescentus. |
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| Journal |
Curr Opin Microbiol 12:715-21 (2009) |
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| Reference |
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| Authors |
Jenal U |
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| Title |
The role of proteolysis in the Caulobacter crescentus cell cycle and development. |
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| Journal |
Res Microbiol 160:687-95 (2009) |
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| Reference |
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| Authors |
Hengge R |
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| Title |
Principles of c-di-GMP signalling in bacteria. |
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| Journal |
Nat Rev Microbiol 7:263-73 (2009) |
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| Reference |
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| Authors |
Goley ED, Toro E, McAdams HH, Shapiro L |
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| Title |
Dynamic chromosome organization and protein localization coordinate the regulatory circuitry that drives the bacterial cell cycle. |
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| Journal |
Cold Spring Harb Symp Quant Biol 74:55-64 (2009) |
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| Reference |
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| Authors |
Li S, Brazhnik P, Sobral B, Tyson JJ |
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| Title |
Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus. |
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| Journal |
PLoS Comput Biol 5:e1000463 (2009) |
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