KEGG   PATHWAY: ko04115Help
Entry
ko04115                     Pathway                                

Name
p53 signaling pathway
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
p53 signaling pathway
ko04115

All organismsOrtholog table
Disease
H00409  
Type II diabetes mellitus
H00848  
Ataxia with ocular apraxia (AOA)
H00881  
Li-Fraumeni syndrome
H00896  
Lymphangioleiomyomatosis (LAM)
H00915  
Tuberous sclerosis complex (TSC)
H00992  
Seckel syndrome
H01007  
Choroid plexus papilloma
H01106  
Plasminogen activator inhibitor type 1 (PAI-1) deficiency
H01195  
VACTERL/VATER association
Orthology
K04728  
ataxia telangiectasia mutated family protein [EC:2.7.11.1]
K06641  
serine/threonine-protein kinase Chk2 [EC:2.7.11.1]
K06640  
serine/threonine-protein kinase ATR [EC:2.7.11.1]
K02216  
serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
K06621  
cyclin-dependent kinase inhibitor 2A
K06643  
E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K10127  
protein Mdm4
K04451  
tumor protein p53
K06625  
cyclin-dependent kinase inhibitor 1A
K04503  
cyclin D1
K10151  
cyclin D2
K10152  
cyclin D3
K02089  
cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091  
cyclin-dependent kinase 6 [EC:2.7.11.22]
K06626  
cyclin E
K02206  
cyclin-dependent kinase 2 [EC:2.7.11.22]
K06644  
stratifin
K10128  
reprimo, TP53-dependent G2 arrest mediator candidate
K05868  
cyclin B
K02087  
cyclin-dependent kinase 1 [EC:2.7.11.23 2.7.11.22]
K04402  
growth arrest and DNA-damage-inducible protein
K10129  
G-2 and S-phase expressed protein 1
K04390  
tumor necrosis factor receptor superfamily member 6
K10130  
leucine-rich repeats and death domain-containing protein
K04398  
caspase 8 [EC:3.4.22.61]
K04726  
BH3 interacting domain death agonist
K02159  
apoptosis regulator BAX
K10131  
phorbol-12-myristate-13-acetate-induced protein 1
K10132  
BCL2-binding component 3
K13773  
p53-regulated apoptosis-inducing protein 1
K10133  
tumor protein p53-inducible protein 3 [EC:1.-.-.-]
K10134  
etoposide-induced 2.4 mRNA
K10135  
scotin
K10136  
TP53 apoptosis effector
K10137  
zinc finger, matrin type 3
K04506  
E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19]
K08738  
cytochrome c
K02084  
apoptotic protease-activating factor
K04399  
caspase 9 [EC:3.4.22.62]
K02187  
caspase 3 [EC:3.4.22.56]
K10138  
insulin-like growth factor-binding protein 3
K05459  
insulin-like growth factor 1
K03982  
plasminogen activator inhibitor-1
K04596  
brain-specific angiogenesis inhibitor 1
K06509  
CD82 antigen
K16857  
thrombospondin 1
K10139  
serpin B5
K10140  
DNA damage-binding protein 2
K10808  
ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10141  
sestrin
K01110  
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.67 3.1.3.48 3.1.3.16]
K07207  
tuberous sclerosis 2
K10142  
metalloreductase STEAP3 [EC:1.16.1.-]
K10143  
E3 ubiquitin-protein ligase RFWD2 [EC:6.3.2.19]
K10144  
RING finger and CHY zinc finger domain-containing protein 1 [EC:6.3.2.19]
K10145  
cyclin G1
K10146  
cyclin G2
K10147  
protein phosphatase 1D [EC:3.1.3.16]
K10148  
tumor protein p73
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)

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