KEGG   PATHWAY: ko04150Help
Entry
ko04150                     Pathway                                

Name
mTOR signaling pathway
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
mTOR signaling pathway
ko04150

All organismsOrtholog table
Disease
H00539  
PTEN hamartoma tumor syndrome (PHTS)
H00666  
Peutz-Jeghers syndrome
H00896  
Lymphangioleiomyomatosis (LAM)
H00915  
Tuberous sclerosis complex (TSC)
H01112  
Polyhydramnios, megalencephaly, and symptomatic epilepsy
H01251  
Focal cortical dysplasia of Taylor
Orthology
K04526  
insulin
K05459  
insulin-like growth factor 1
K16172  
insulin receptor substrate 1
K02649  
phosphoinositide-3-kinase, regulatory subunit
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K01110  
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.67 3.1.3.48 3.1.3.16]
K06276  
3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
K16184  
proline-rich AKT1 substrate 1
K07206  
tuberous sclerosis 1
K07207  
tuberous sclerosis 2
K07208  
Ras homolog enriched in brain
K08266  
G protein beta subunit-like
K16185  
Ras-related GTP-binding protein A/B
K16186  
Ras-related GTP-binding protein C/D
K07203  
FKBP12-rapamycin complex-associated protein
K07204  
regulatory associated protein of mTOR
K08267  
rapamycin-insensitive companion of mTOR
K08268  
hypoxia-inducible factor 1 alpha
K05448  
vascular endothelial growth factor A
K04688  
p70 ribosomal S6 kinase [EC:2.7.11.1]
K03258  
translation initiation factor 4B
K02991  
small subunit ribosomal protein S6e
K07205  
eukaryotic translation initiation factor 4E binding protein 1
K03259  
translation initiation factor 4E
K08269  
serine/threonine-protein kinase ULK/ATG1 [EC:2.7.11.1]
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04373  
p90 ribosomal S6 kinase [EC:2.7.11.1]
K08270  
DNA-damage-inducible transcript 4
K03156  
tumor necrosis factor superfamily, member 2
K07209  
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07298  
serine/threonine-protein kinase 11
K08271  
STE20-related kinase adapter protein alpha
K08272  
calcium binding protein 39
K07198  
5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K04365  
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K02677  
classical protein kinase C [EC:2.7.11.13]
Compound
C00020  
AMP
C04677  
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C15181  
Wortmannin
C15182  
Temsirolimus
C15183  
AP 23573
C15195  
LY 294002
D00753  
Sirolimus (JAN/USAN/INN)
D00944  
Metformin hydrochloride (JP16/USP)
D02714  
Everolimus (JAN/USAN/INN)
Reference
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
Reference
  Authors
Petroulakis E, Mamane Y, Le Bacquer O, Shahbazian D, Sonenberg N.
  Title
mTOR signaling: implications for cancer and anticancer therapy.
  Journal
Br J Cancer 94:195-9 (2006)
Reference
  Authors
Sarbassov dos D, Ali SM, Sabatini DM.
  Title
Growing roles for the mTOR pathway.
  Journal
Curr Opin Cell Biol 17:596-603 (2005)
Reference
  Authors
Wullschleger S, Loewith R, Hall MN.
  Title
TOR signaling in growth and metabolism.
  Journal
Cell 124:471-84 (2006)
Reference
  Authors
Plas DR, Thompson CB.
  Title
Akt-dependent transformation: there is more to growth than just surviving.
  Journal
Oncogene 24:7435-42 (2005)
Reference
  Authors
Levine AJ, Feng Z, Mak TW, You H, Jin S
  Title
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.
  Journal
Genes Dev 20:267-75 (2006)
Reference
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
Reference
  Authors
Hardie DG.
  Title
New roles for the LKB1-->AMPK pathway.
  Journal
Curr Opin Cell Biol 17:167-73 (2005)
Reference
  Authors
Astrinidis A, Henske EP.
  Title
Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease.
  Journal
Oncogene 24:7475-81 (2005)
Reference
  Authors
Feng Z, Zhang H, Levine AJ, Jin S.
  Title
The coordinate regulation of the p53 and mTOR pathways in cells.
  Journal
Proc Natl Acad Sci U S A 102:8204-9 (2005)
Reference
  Authors
Altomare DA, Testa JR.
  Title
Perturbations of the AKT signaling pathway in human cancer.
  Journal
Oncogene 24:7455-64 (2005)
Reference
  Authors
Kwiatkowski DJ, Manning BD.
  Title
Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.
  Journal
Hum Mol Genet 14 Spec No. 2:R251-8 (2005)
Reference
  Authors
Guertin DA, Sabatini DM.
  Title
An expanding role for mTOR in cancer.
  Journal
Trends Mol Med 11:353-61 (2005)
Reference
  Authors
Tokunaga C, Yoshino K, Yonezawa K.
  Title
mTOR integrates amino acid- and energy-sensing pathways.
  Journal
Biochem Biophys Res Commun 313:443-6 (2004)
Reference
  Authors
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB.
  Title
Exploiting the PI3K/AKT pathway for cancer drug discovery.
  Journal
Nat Rev Drug Discov 4:988-1004 (2005)
Reference
  Authors
Luo Z, Saha AK, Xiang X, Ruderman NB.
  Title
AMPK, the metabolic syndrome and cancer.
  Journal
Trends Pharmacol Sci 26:69-76 (2005)
Reference
  Authors
Tee AR, Blenis J.
  Title
mTOR, translational control and human disease.
  Journal
Semin Cell Dev Biol 16:29-37 (2005)
Reference
  Authors
Proud CG.
  Title
Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy.
  Journal
Cardiovasc Res 63:403-13 (2004)
Reference
  Authors
Sofer A, Lei K, Johannessen CM, Ellisen LW.
  Title
Regulation of mTOR and cell growth in response to energy stress by REDD1.
  Journal
Mol Cell Biol 25:5834-45 (2005)
Reference
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
Reference
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
Reference
  Authors
Brugarolas J, Kaelin WG Jr.
  Title
Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes.
  Journal
Cancer Cell 6:7-10 (2004)
Reference
  Authors
Hui L, Rodrik V, Pielak RM, Knirr S, Zheng Y, Foster DA.
  Title
mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells.
  Journal
J Biol Chem 280:35829-35 (2005)
Reference
  Authors
Hall MN
  Title
mTOR-what does it do?
  Journal
Transplant Proc 40:S5-8 (2008)
Reference
  Authors
Rosner M, Hanneder M, Siegel N, Valli A, Fuchs C, Hengstschlager M
  Title
The mTOR pathway and its role in human genetic diseases.
  Journal
Mutat Res 659:284-92 (2008)
Reference
  Authors
Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL
  Title
Regulation of TORC1 by Rag GTPases in nutrient response.
  Journal
Nat Cell Biol 10:935-45 (2008)
Reference
  Authors
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM
  Title
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
  Journal
Science 320:1496-501 (2008)
Reference
  Authors
Hoeffer CA, Klann E
  Title
mTOR signaling: at the crossroads of plasticity, memory and disease.
  Journal
Trends Neurosci 33:67-75 (2010)

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