KEGG   PATHWAY: ko04150Help
Entry
ko04150                     Pathway                                

Name
mTOR signaling pathway
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
mTOR signaling pathway
ko04150

All organismsOrtholog table
Disease
H00539  
PTEN hamartoma tumor syndrome (PHTS)
H00666  
Peutz-Jeghers syndrome
H00896  
Lymphangioleiomyomatosis (LAM)
H00915  
Tuberous sclerosis complex (TSC)
H01112  
Polyhydramnios, megalencephaly, and symptomatic epilepsy
H01251  
Focal cortical dysplasia of Taylor
Orthology
K13780  
solute carrier family 7 (L-type amino acid transporter), member 5
K06519  
solute carrier family 3, member 2
K14995  
solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9
K02145  
V-type H+-transporting ATPase subunit A [EC:3.6.3.14]
K02147  
V-type H+-transporting ATPase subunit B
K02148  
V-type H+-transporting ATPase subunit C
K02149  
V-type H+-transporting ATPase subunit D
K02150  
V-type H+-transporting ATPase subunit E
K02151  
V-type H+-transporting ATPase subunit F
K02152  
V-type H+-transporting ATPase subunit G
K02144  
V-type H+-transporting ATPase subunit H
K20397  
ragulator complex protein LAMTOR1
K20398  
ragulator complex protein LAMTOR2
K04370  
ragulator complex protein LAMTOR3
K20399  
ragulator complex protein LAMTOR4
K16344  
ragulator complex protein LAMTOR5
K09594  
folliculin
K20400  
folliculin-interacting protein 1
K20401  
folliculin-interacting protein 2
K16185  
Ras-related GTP-binding protein A/B
K16186  
Ras-related GTP-binding protein C/D
K07204  
regulatory associated protein of mTOR
K16184  
proline-rich AKT1 substrate 1
K07203  
serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K20402  
DEP domain-containing mTOR-interacting protein
K08266  
target of rapamycin complex subunit LST8
K11137  
telomere length regulation protein
K20403  
TELO2-interacting protein 1
K10421  
CAP-Gly domain-containing linker protein 1
K20064  
growth factor receptor-bound protein 10
K08269  
serine/threonine-protein kinase ULK/ATG1 [EC:2.7.11.1]
K07205  
eukaryotic translation initiation factor 4E binding protein 1
K03259  
translation initiation factor 4E
K04688  
p70 ribosomal S6 kinase [EC:2.7.11.1]
K03258  
translation initiation factor 4B
K02991  
small subunit ribosomal protein S6e
K15705  
E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27]
K03875  
F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K20404  
DEP domain-containing protein 5
K20405  
nitrogen permease regulator 2-like protein
K20406  
nitrogen permease regulator 3-like protein
K20407  
WD repeat-containing protein mio
K14299  
nucleoporin SEH1
K20408  
WD repeat-containing protein 24
K20409  
WD repeat-containing protein 59
K14004  
protein transport protein SEC13
K20394  
sestrin 2
K08271  
STE20-related kinase adapter protein alpha
K17532  
STE20-related kinase adapter protein beta
K07298  
serine/threonine-protein kinase 11
K08272  
calcium binding protein 39
K07198  
5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07206  
tuberous sclerosis 1
K07207  
tuberous sclerosis 2
K20396  
TBC1 domain family member 7
K07208  
Ras homolog enriched in brain
K08270  
DNA-damage-inducible transcript 4
K03209  
wingless-type MMTV integration site family, member 1
K00182  
wingless-type MMTV integration site family, member 2
K00312  
wingless-type MMTV integration site family, member 3
K00408  
wingless-type MMTV integration site family, member 4
K00444  
wingless-type MMTV integration site family, member 5
K00445  
wingless-type MMTV integration site family, member 6
K00572  
wingless-type MMTV integration site family, member 7
K00714  
wingless-type MMTV integration site family, member 8
K01064  
wingless-type MMTV integration site family, member 9
K01357  
wingless-type MMTV integration site family, member 10
K01384  
wingless-type MMTV integration site family, member 11
K01558  
wingless-type MMTV integration site family, member 16
K02432  
frizzled 1/7
K02235  
frizzled 2
K02329  
frizzled 3
K02354  
frizzled 4
K02375  
frizzled 5/8
K02376  
frizzled 6
K02842  
frizzled 9/10
K04690  
frizzled
K03068  
low density lipoprotein receptor-related protein 5/6
K02353  
segment polarity protein dishevelled
K03083  
glycogen synthase kinase 3 beta [EC:2.7.11.26]
K03156  
tumor necrosis factor superfamily, member 2
K03158  
tumor necrosis factor receptor superfamily member 1A
K07209  
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K04526  
insulin
K05459  
insulin-like growth factor 1
K04527  
insulin receptor [EC:2.7.10.1]
K05087  
insulin-like growth factor 1 receptor [EC:2.7.10.1]
K04364  
growth factor receptor-binding protein 2
K03099  
son of sevenless
K02833  
GTPase HRas
K07827  
GTPase KRas
K07828  
GTPase NRas
K04365  
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04373  
p90 ribosomal S6 kinase [EC:2.7.11.1]
K16172  
insulin receptor substrate 1
K02649  
phosphoinositide-3-kinase, regulatory subunit
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K01110  
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.67 3.1.3.48 3.1.3.16]
K06276  
3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467  
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K20410  
target of rapamycin complex 2 subunit MAPKAP1
K08267  
rapamycin-insensitive companion of mTOR
K20411  
proline-rich protein 5
K04513  
Ras homolog gene family, member A
K02677  
classical protein kinase C alpha type [EC:2.7.11.13]
K19662  
classical protein kinase C beta type [EC:2.7.11.13]
K19663  
classical protein kinase C gamma type [EC:2.7.11.13]
K13302  
serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
Compound
C00020  
AMP
C00123  
L-Leucine
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
Reference
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
Reference
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
Reference
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
Reference
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
Reference
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
Reference
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
Reference
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
Reference
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
Reference
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
Reference
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
Reference
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
Reference
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
Reference
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
Reference
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
Reference
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget (2016)

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