KEGG   PATHWAY: ko04512Help
Entry
ko04512                     Pathway                                

Name
ECM-receptor interaction
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ECM-receptor interaction
ko04512

All organismsOrtholog table
Disease
H00219  
Hemophilia
H00224  
Bernard-Soulier syndrome
H00226  
Glanzmann thrombasthenia
H00576  
Pierson syndrome
H00579  
Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
H00581  
Alport syndrome
H00582  
Benign familial hematuria
H00585  
Epidermolysis bullosa, hemidesmosomal
H00586  
Epidermolysis bullosa, junctional
H00770  
Congenital myasthenic syndrome
H00802  
Ehlers-Danlos syndrome (EDS)
H00805  
Vitreoretinal degeneration
H00813  
Laryngo onycho cutaneous syndrome
H00839  
Porencephaly
H00877  
Brain small vessel disease with Axenfeld-Rieger anomaly
H01260  
Glomerulopathy with fibronectin deposits (GFND)
H01338  
Myosclerosis
H01340  
Bethlem myopathy
H01341  
Collagen VI myopathy
Other DBs
BSID: 
GO: 
Orthology
K06236  
collagen, type I/II/III/V/XI/XXIV/XXVII, alpha
K06237  
collagen, type IV, alpha
K06238  
collagen, type VI, alpha
K05637  
laminin, alpha 1/2
K06240  
laminin, alpha 3/5
K06241  
laminin, alpha 4
K05636  
laminin, beta 1
K06243  
laminin, beta 2
K06244  
laminin, beta 3
K06245  
laminin, beta 4
K05635  
laminin, gamma 1
K06246  
laminin, gamma 2
K06247  
laminin, gamma 3
K06248  
chondroadherin
K06249  
reelin [EC:3.4.21.-]
K16857  
thrombospondin 1
K04659  
thrombospondin 2/3/4/5
K05717  
fibronectin 1
K06250  
secreted phosphoprotein 1
K06251  
vitronectin
K06252  
tenascin
K03900  
von Willebrand factor
K06253  
integrin binding sialoprotein
K06254  
agrin
K06255  
heparan sulfate proteoglycan 2 (perlecan)
K06480  
integrin alpha 1
K06481  
integrin alpha 2
K06476  
integrin alpha 2B
K06482  
integrin alpha 3
K06483  
integrin alpha 4
K06484  
integrin alpha 5
K06485  
integrin alpha 6
K06583  
integrin alpha 7
K06584  
integrin alpha 8
K06585  
integrin alpha 9
K06586  
integrin alpha 10
K06587  
integrin alpha 11
K06487  
integrin alpha V
K05719  
integrin beta 1
K06493  
integrin beta 3
K06525  
integrin beta 4
K06588  
integrin beta 5
K06589  
integrin beta 6
K06590  
integrin beta 7
K06591  
integrin beta 8
K06256  
CD44 antigen
K06257  
syndecan 1
K16338  
syndecan 4
K06258  
MFS transporter, VNT family, synaptic vesicle glycoprotein 2
K06259  
CD36 antigen
K06260  
platelet glycoprotein V
K06261  
platelet glycoprotein Ib alpha chain
K06262  
platelet glycoprotein Ib beta chain
K06263  
platelet glycoprotein IX
K06264  
platelet glycoprotein VI
K06265  
dystroglycan 1
K06266  
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
K06267  
hyaluronan-mediated motility receptor
Compound
G02170  
Hyaluronan
Reference
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
Reference
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
Reference
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
Reference
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
Reference
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
Reference
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
Reference
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
Reference
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
Reference
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
Reference
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)

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