KEGG   PATHWAY: ko04612Help
Entry
ko04612                     Pathway                                

Name
Antigen processing and presentation
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Antigen processing and presentation
ko04612

All organismsOrtholog table
Disease
H00344  
Leprosy
H00425  
Lysosomal cysteine protease deficiencies
H00932  
Tropical calcific pancreatitis
H00984  
Bare lymphocyte syndrome (BLS) type1
H00985  
Bare lymphocyte syndrome (BLS) type2
H01132  
Aplastic anemia (AA)
H01227  
Inflammatory bowel disease (IBD)
H01303  
Hypercatabolic hypoproteinemia
H01674  
Ankylosing spondylitis
Other DBs
Orthology
K04687  
interferon gamma
K03156  
tumor necrosis factor superfamily, member 2
K06696  
proteasome activator subunit 1 (PA28 alpha)
K06697  
proteasome activator subunit 2 (PA28 beta)
K06698  
proteasome activator subunit 3 (PA28 gamma)
K03283  
heat shock 70kDa protein 1/2/6/8
K09489  
heat shock 70kDa protein 4
K04079  
molecular chaperone HtpG
K06751  
major histocompatibility complex, class I
K08054  
calnexin
K08055  
beta-2-microglobulin
K08056  
protein disulfide isomerase family A, member 3 [EC:5.3.4.1]
K08057  
calreticulin
K08058  
TAP binding protein (tapasin)
K05653  
ATP-binding cassette, subfamily B (MDR/TAP), member 2
K05654  
ATP-binding cassette, subfamily B (MDR/TAP), member 3
K06458  
T-cell surface glycoprotein CD8 alpha chain
K06459  
T-cell surface glycoprotein CD8 beta chain
K10784  
T cell receptor alpha chain V region
K10785  
T-cell receptor beta chain V region
K07980  
killer cell immunoglobulin-like receptor 3DL
K07981  
killer cell immunoglobulin-like receptor 2DL
K06541  
killer cell lectin-like receptor subfamily C
K06516  
killer cell lectin-like receptor subfamily D member 1
K07982  
killer cell immunoglobulin-like receptor 2DS
K08059  
interferon, gamma-inducible protein 30
K01369  
legumain [EC:3.4.22.34]
K01363  
cathepsin B [EC:3.4.22.1]
K06752  
major histocompatibility complex, class II
K06505  
CD74 antigen
K01365  
cathepsin L [EC:3.4.22.15]
K01368  
cathepsin S [EC:3.4.22.27]
K06454  
T-cell surface glycoprotein CD4
K08060  
class II, major histocompatibility complex, transactivator
K08061  
regulatory factor X 5
K08062  
regulatory factor X-associated ankyrin-containing protein
K08063  
regulatory factor X-associated protein
K05870  
cyclic AMP-responsive element-binding protein 1
K08064  
nuclear transcription factor Y, alpha
K08065  
nuclear transcription Y subunit beta
K08066  
nuclear transcription factor Y, gamma
Reference
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687

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