| Entry |
|
|---|
| Name |
Renin-angiotensin system
|
|---|
| Class |
Organismal Systems; Endocrine system
 |
|---|
| Pathway map |
  |
|---|
| Disease |
| Uromodulin-associated kidney diseases | | Renal tubular dysgenesis |
|
|---|
| Orthology |
| angiotensinogen | | | | | | angiotensin-converting enzyme 2 [EC: 3.4.17.23] | | | | | | | | | | cathepsin A (carboxypeptidase C) [EC: 3.4.16.5] | | | | | | | | | | MAS1 oncogene | | angiotensin II receptor type 1 | | angiotensin II receptor type 2 | | |
|
|---|
| Compound |
| Angiotensin I | | Angiotensin II | | Angiotensin III | | Angiotensin IV | | Angiotensin (1-7) | | Angiotensin (1-9) | | Angiotensin (1-5) |
|
|---|
| Reference |
|
|---|
| Authors |
Kramkowski K, Mogielnicki A, Buczko W. |
|---|
| Title |
The physiological significance of the alternative pathways of angiotensin II production. |
|---|
| Journal |
J Physiol Pharmacol 57:529-39 (2006) |
|---|
| Reference |
|
|---|
| Authors |
Danilczyk U, Eriksson U, Oudit GY, Penninger JM. |
|---|
| Title |
Physiological roles of angiotensin-converting enzyme 2. |
|---|
| Journal |
Cell Mol Life Sci 61:2714-9 (2004) |
|---|
| Reference |
|
|---|
| Authors |
Warner FJ, Smith AI, Hooper NM, Turner AJ. |
|---|
| Title |
Angiotensin-converting enzyme-2: a molecular and cellular perspective. |
|---|
| Journal |
Cell Mol Life Sci 61:2704-13 (2004) |
|---|
| Reference |
|
|---|
| Authors |
Kurdi M, De Mello WC, Booz GW. |
|---|
| Title |
Working outside the system: an update on the unconventional behavior of the renin-angiotensin system components. |
|---|
| Journal |
Int J Biochem Cell Biol 37:1357-67 (2005) |
|---|
| Reference |
|
|---|
| Authors |
Burrell LM, Johnston CI, Tikellis C, Cooper ME. |
|---|
| Title |
ACE2, a new regulator of the renin-angiotensin system. |
|---|
| Journal |
Trends Endocrinol Metab 15:166-9 (2004) |
|---|
| Reference |
|
|---|
| Authors |
von Bohlen und Halbach O, Albrecht D. |
|---|
| Title |
The CNS renin-angiotensin system. |
|---|
| Journal |
Cell Tissue Res 326:599-616 (2006) |
|---|
| Reference |
|
|---|
| Authors |
Schmaier AH. |
|---|
| Title |
The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction. |
|---|
| Journal |
Am J Physiol Regul Integr Comp Physiol 285:R1-13 (2003) |
|---|
| Reference |
|
|---|
| Authors |
Eriksson U, Danilczyk U, Penninger JM. |
|---|
| Title |
Just the beginning: novel functions for angiotensin-converting enzymes. |
|---|
| Journal |
Curr Biol 12:R745-52 (2002) |
|---|
| Reference |
|
|---|
| Authors |
Dielis AW, Smid M, Spronk HM, Hamulyak K, Kroon AA, ten Cate H, de Leeuw PW. |
|---|
| Title |
The prothrombotic paradox of hypertension: role of the renin-angiotensin and kallikrein-kinin systems. |
|---|
| Journal |
Hypertension 46:1236-42 (2005) |
|---|
| Reference |
|
|---|
| Authors |
Kuba K, Imai Y, Penninger JM. |
|---|
| Title |
Angiotensin-converting enzyme 2 in lung diseases. |
|---|
| Journal |
Curr Opin Pharmacol 6:271-6 (2006) |
|---|
| Reference |
|
|---|
| Authors |
Erdos EG, Jackman HL, Brovkovych V, Tan F, Deddish PA. |
|---|
| Title |
Products of angiotensin I hydrolysis by human cardiac enzymes potentiate bradykinin. |
|---|
| Journal |
J Mol Cell Cardiol 34:1569-76 (2002) |
|---|
| Reference |
|
|---|
| Authors |
Shrimpton CN, Smith AI, Lew RA. |
|---|
| Title |
Soluble metalloendopeptidases and neuroendocrine signaling. |
|---|
| Journal |
Endocr Rev 23:647-64 (2002) |
|---|
| Reference |
|
|---|
| Authors |
Jackman HL, Massad MG, Sekosan M, Tan F, Brovkovych V, Marcic BM, Erdos EG. |
|---|
| Title |
Angiotensin 1-9 and 1-7 release in human heart: role of cathepsin A. |
|---|
| Journal |
Hypertension 39:976-81 (2002) |
|---|
| Reference |
|
|---|
| Authors |
Lundequist A, Tchougounova E, Abrink M, Pejler G. |
|---|
| Title |
Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. |
|---|
| Journal |
J Biol Chem 279:32339-44 (2004) |
|---|
| Reference |
|
|---|
| Authors |
Kehoe PG, Wilcock GK. |
|---|
| Title |
Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease? |
|---|
| Journal |
Lancet Neurol 6:373-8 (2007) |
|---|
