KEGG   PATHWAY: ko04622Help
Entry
ko04622                     Pathway                                

Name
RIG-I-like receptor signaling pathway
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
RIG-I-like receptor signaling pathway
ko04622

All organismsOrtholog table
Disease
H00827  
Brooke-Spiegler syndrome
H00882  
Cocoon syndrome
Orthology
K12646  
ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
K12647  
interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]
K12648  
mitochondrial antiviral-signaling protein
K12649  
ATP-dependent RNA helicase DHX58 [EC:3.6.3.14]
K03174  
TNF receptor-associated factor 3
K12650  
TRAF family member-associated NF-kappa-B activator
K12651  
5-azacytidine-induced protein 2
K12652  
TANK-binding kinase 1-binding protein
K07210  
inhibitor of nuclear factor kappa-B kinase subunit gamma
K05410  
TANK-binding kinase 1 [EC:2.7.11.10]
K07211  
inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
K05411  
interferon regulatory factor 3
K09447  
interferon regulatory factor 7
K05414  
interferon alpha
K05415  
interferon beta
K05440  
interferon, omega 1
K05442  
interferon, tau-1
K05441  
interferon, kappa
K03171  
tumor necrosis factor receptor type 1-associated DEATH domain protein
K02373  
FAS-associated death domain protein
K02861  
receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K04398  
caspase 8 [EC:3.4.22.61]
K04400  
caspase 10 [EC:3.4.22.63]
K04467  
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209  
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K02581  
NF-kappa-B inhibitor beta
K04734  
NF-kappa-B inhibitor alpha
K02580  
nuclear factor NF-kappa-B p105 subunit
K04735  
transcription factor p65
K03173  
TNF receptor-associated factor 2
K04427  
mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K03175  
TNF receptor-associated factor 6
K04416  
mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04440  
c-Jun N-terminal kinase [EC:2.7.11.24]
K04441  
p38 MAP kinase [EC:2.7.11.24]
K10030  
interleukin 8
K03156  
tumor necrosis factor superfamily, member 2
K05406  
interleukin 12A
K05425  
interleukin 12B
K12671  
C-X-C motif chemokine 10
K10652  
tripartite motif-containing protein 25 [EC:6.3.2.19]
K08601  
ubiquitin thioesterase CYLD [EC:3.1.2.15]
K12170  
E3 ubiquitin-protein ligase RNF125 [EC:6.3.2.19]
K12159  
ubiquitin cross-reactive protein
K08339  
autophagy-related protein 5
K08336  
ubiquitin-like protein ATG12
K12653  
NLR family member X1
K12654  
transmembrane protein 173
K12655  
OTU domain-containing protein 5 [EC:3.4.19.12]
K12656  
suppressor of IKK-epsilon
K11594  
ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
K09578  
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
K00863  
dihydroxyacetone kinase [EC:2.7.1.29]
Reference
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
Reference
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
Reference
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
Reference
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
Reference
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
Reference
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
Reference
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
Reference
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
Reference
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
Reference
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
Reference
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
Reference
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)

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