KEGG   PATHWAY: ko04622Help
Entry
ko04622                     Pathway                                

Name
RIG-I-like receptor signaling pathway
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
ko04622  RIG-I-like receptor signaling pathway
ko04622

Ortholog table
Disease
H00827  Brooke-Spiegler syndrome
H00882  Cocoon syndrome
H01746  STING-associated vasculopathy with onset in infancy (SAVI)
Orthology
K12646  ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
K12647  interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]
K12648  mitochondrial antiviral-signaling protein
K12649  ATP-dependent RNA helicase DHX58 [EC:3.6.3.14]
K03174  TNF receptor-associated factor 3
K12650  TRAF family member-associated NF-kappa-B activator
K12651  5-azacytidine-induced protein 2
K12652  TANK-binding kinase 1-binding protein
K07210  inhibitor of nuclear factor kappa-B kinase subunit gamma
K05410  TANK-binding kinase 1 [EC:2.7.11.10]
K07211  inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
K05411  interferon regulatory factor 3
K09447  interferon regulatory factor 7
K05414  interferon alpha
K05415  interferon beta
K05440  interferon omega
K05442  interferon epsilon
K05441  interferon kappa
K03171  tumor necrosis factor receptor type 1-associated DEATH domain protein
K02373  FAS-associated death domain protein
K02861  receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K04398  caspase 8 [EC:3.4.22.61]
K04400  caspase 10 [EC:3.4.22.63]
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K02581  NF-kappa-B inhibitor beta
K04734  NF-kappa-B inhibitor alpha
K02580  nuclear factor NF-kappa-B p105 subunit
K04735  transcription factor p65
K03173  TNF receptor-associated factor 2 [EC:2.3.2.27]
K04427  mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K03175  TNF receptor-associated factor 6 [EC:2.3.2.27]
K04416  mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04441  p38 MAP kinase [EC:2.7.11.24]
K10030  interleukin 8
K03156  tumor necrosis factor superfamily, member 2
K05406  interleukin 12A
K05425  interleukin 12B
K12671  C-X-C motif chemokine 10
K10652  tripartite motif-containing protein 25 [EC:2.3.2.27]
K08601  ubiquitin thioesterase [EC:3.4.19.12]
K12170  E3 ubiquitin-protein ligase RNF125 [EC:2.3.2.27]
K12159  ubiquitin cross-reactive protein
K08339  autophagy-related protein 5
K08336  ubiquitin-like protein ATG12
K12653  NLR family member X1
K12654  transmembrane protein 173
K12655  OTU domain-containing protein 5 [EC:3.4.19.12]
K12656  suppressor of IKK-epsilon
K11594  ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
K09578  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
K00863  triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing) [EC:4.6.1.15 2.7.1.29 2.7.1.28]
Reference
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200

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