KEGG   PATHWAY: ko04630Help
Entry
ko04630                     Pathway                                

Name
Jak-STAT signaling pathway
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Jak-STAT signaling pathway
ko04630

All organismsOrtholog table
Module
M00684  
JAK-STAT signaling [PATH:ko04630]
Disease
H00286  
Crohn's disease
H00408  
Type I diabetes mellitus
H00539  
PTEN hamartoma tumor syndrome (PHTS)
H00931  
Growth hormone insensitivity with immunodeficiency
H00935  
Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
H01018  
Metachondromatosis
H01109  
Chronic mucocutaneous candidiasis (CMC)
H01122  
Pulmonary alveolar proteinosis (PAP)
H01217  
Primary localized cutaneous amyloidosis (PLCA)
H01227  
Inflammatory bowel disease (IBD)
H01388  
Hyperprolactinemia
H01466  
Ulcerative colitis (UC)
H01479  
Castleman disease
H01502  
Sjogren's Syndrome
H01605  
Myelofibrosis
Other DBs
BSID: 
GO: 
Orthology
K05429  
interleukin 2
K04736  
interleukin 3
K05430  
interleukin 4
K05428  
interleukin 5
K05405  
interleukin 6
K05431  
interleukin 7
K05432  
interleukin 9
K05443  
interleukin 10
K05417  
interleukin 11
K05406  
interleukin 12A
K05425  
interleukin 12B
K05435  
interleukin 13
K05433  
interleukin 15
K05444  
interleukin 19/20/24
K05434  
interleukin 21
K05445  
interleukin 22
K05426  
interleukin 23, alpha subunit p19
K05492  
interleukin 17D
K05414  
interferon alpha
K05415  
interferon beta
K04687  
interferon gamma
K05442  
interferon epsilon
K05441  
interferon kappa
K05447  
interleukin 28/29 (interferon lambda)
K05440  
interferon omega
K05418  
oncostatin M
K05419  
leukemia inhibitory factor
K05436  
thymic stromal lymphopoietin
K05422  
cardiotrophin 1
K05427  
granulocyte-macrophage colony-stimulating factor
K16689  
unpaired
K05420  
ciliary neurotrophic factor
K05423  
granulocyte colony-stimulating factor
K05437  
erythropoietin
K05438  
growth hormone
K05424  
leptin
K06854  
thrombopoietin
K05439  
prolactin
K05068  
interleukin 2 receptor alpha
K05069  
interleukin 2 receptor beta
K05070  
interleukin 2 receptor gamma
K04737  
interleukin 3 receptor alpha
K05071  
interleukin 4 receptor
K05067  
interleukin 5 receptor alpha
K05055  
interleukin 6 receptor
K05072  
interleukin 7 receptor
K05073  
interleukin 9 receptor
K05134  
interleukin 10 receptor alpha
K05135  
interleukin 10 receptor beta
K05056  
interleukin 11 receptor alpha
K05063  
interleukin 12 receptor beta-1
K05064  
interleukin 12 receptor beta-2
K05076  
interleukin 13 receptor alpha-1
K05077  
interleukin 13 receptor alpha-2
K05074  
interleukin 15 receptor alpha
K05136  
interleukin 20 receptor alpha
K05137  
interleukin 20 receptor beta
K05075  
interleukin 21 receptor
K05138  
interleukin 22 receptor alpha 1
K05139  
interleukin 22 receptor alpha 2
K05065  
interleukin 23 receptor
K19598  
interleukin 27 receptor alpha
K05060  
interleukin 6 signal transducer
K05130  
interferon receptor 1
K05131  
interferon receptor 2
K05132  
interferon gamma receptor 1
K05133  
interferon gamma receptor 2
K05140  
interferon lambda receptor 1
K05057  
oncostatin M receptor
K05058  
leukemia inhibitory factor receptor
K05078  
thymic stromal-derived lymphopoietin receptor
K05059  
ciliary neurotrophic factor receptor
K05066  
granulocyte-macrophage colony-stimulating factor receptor alpha
K04738  
cytokine receptor common subunit beta
K05061  
granulocyte colony-stimulating factor receptor
K05079  
erythropoietin receptor
K05080  
growth hormone receptor
K05062  
leptin receptor
K05082  
thrombopoietin receptor
K05081  
prolactin receptor
K19599  
cytokine receptor domeless
K11217  
Janus kinase 1 [EC:2.7.10.2]
K04447  
Janus kinase 2 [EC:2.7.10.2]
K11218  
Janus kinase 3 [EC:2.7.10.2]
K11219  
non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
K11220  
signal transducer and activator of transcription 1
K11221  
signal transducer and activator of transcription 2
K04692  
signal transducer and activator of transcription 3
K11222  
signal transducer and activator of transcription 4
K11223  
signal transducer and activator of transcription 5A
K11224  
signal transducer and activator of transcription 5B
K11225  
signal transducer and activator of transcription 6
K04701  
cytokine inducible SH2-containing protein
K04694  
suppressor of cytokine signaling 1
K04695  
suppressor of cytokine signaling 2
K04696  
suppressor of cytokine signaling 3
K04697  
suppressor of cytokine signaling 4
K04698  
suppressor of cytokine signaling 5
K04699  
suppressor of cytokine signaling 6/7
K02161  
apoptosis regulator Bcl-2
K02539  
myeloid leukemia cell differntiation protein MCL-1
K04570  
Bcl-2-like 1 (apoptosis regulator Bcl-X)
K04702  
proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]
K04377  
Myc proto-oncogene protein
K04503  
cyclin D1
K10151  
cyclin D2
K10152  
cyclin D3
K06625  
cyclin-dependent kinase inhibitor 1A
K00157  
aldehyde oxidase [EC:1.2.3.1]
K05640  
glial fibrillary acidic protein
K04705  
signal transducing adaptor molecule
K18026  
tyrosine-protein phosphatase non-receptor type 2 [EC:3.1.3.48]
K05697  
tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
K04693  
interferon regulatory factor 9
K04498  
E1A/CREB-binding protein [EC:2.3.1.48]
K04706  
E3 SUMO-protein ligase PIAS1
K16063  
E3 SUMO-protein ligase PIAS2
K16064  
E3 SUMO-protein ligase PIAS3
K16065  
E3 SUMO-protein ligase PIAS4
K14365  
four and a half LIM domains protein 1
K07293  
tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K04364  
growth factor receptor-binding protein 2
K03099  
son of sevenless
K02833  
GTPase HRas
K04366  
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649  
phosphoinositide-3-kinase, regulatory subunit
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
K07203  
serine/threonine-protein kinase mTOR [EC:2.7.11.1]
Reference
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4 (2012)
Reference
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
Reference
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
Reference
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
Reference
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
Reference
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
Reference
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
Reference
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
Reference
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
Reference
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
Reference
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)

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