KEGG   PATHWAY: ko04666Help
Entry
ko04666                     Pathway                                

Name
Fc gamma R-mediated phagocytosis
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Fc gamma R-mediated phagocytosis
ko04666

All organismsOrtholog table
Disease
H00098  
Chronic granulomatous disease
H00698  
Nemaline myopathy
H00833  
Neurodegeneration with brain iron accumulation (NBIA)
H01240  
Immune thrombocytopenia (ITP)
H01387  
Activated PI3K-delta syndrome (APDS)
Drug
D05994  
Talizumab (USAN/INN)
Other DBs
BSID: 
GO: 
Orthology
K06856  
immunoglobulin heavy chain
K06498  
high affinity immunoglobulin gamma Fc receptor I
K06472  
low affinity immunoglobulin gamma Fc region receptor II-a
K06478  
receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]
K08893  
hemopoietic cell kinase [EC:2.7.10.2]
K05854  
tyrosine-protein kinase Lyn [EC:2.7.10.2]
K05855  
spleen tyrosine kinase [EC:2.7.10.2]
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649  
phosphoinositide-3-kinase, regulatory subunit
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04688  
p70 ribosomal S6 kinase [EC:2.7.11.1]
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K06068  
novel protein kinase C delta type [EC:2.7.11.13]
K18050  
novel protein kinase C epsilon type [EC:2.7.11.13]
K04366  
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K12561  
myristoylated alanine-rich C-kinase substrate
K13536  
MARCKS-related protein
K01115  
phospholipase D1/2 [EC:3.1.4.4]
K01080  
phosphatidate phosphatase [EC:3.1.3.4]
K04718  
sphingosine kinase [EC:2.7.1.91]
K02677  
classical protein kinase C [EC:2.7.11.13]
K08011  
neutrophil cytosolic factor 1
K05768  
gelsolin
K05730  
guanine nucleotide exchange factor VAV
K04393  
cell division control protein 42
K05747  
Wiskott-Aldrich syndrome protein
K06274  
vasodilator-stimulated phosphoprotein
K05754  
actin related protein 2/3 complex, subunit 5
K05755  
actin related protein 2/3 complex, subunit 4
K05756  
actin related protein 2/3 complex, subunit 3
K05757  
actin related protein 2/3 complex, subunit 1A/1B
K05758  
actin related protein 2/3 complex, subunit 2
K04392  
Ras-related C3 botulinum toxin substrate 1
K07860  
Ras-related C3 botulinum toxin substrate 2
K05753  
WAS protein family, member 1
K05748  
WAS protein family, member 2
K06083  
WAS protein family, member 3
K04409  
p21-activated kinase 1 [EC:2.7.11.1]
K05743  
LIM domain kinase 1 [EC:2.7.11.1]
K05744  
LIM domain kinase 2 [EC:2.7.11.1]
K05765  
cofilin
K00889  
1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K07941  
ADP-ribosylation factor 6
K04438  
proto-oncogene C-crk
K12367  
dedicator of cytokinesis protein 2
K12488  
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
K12560  
low affinity immunoglobulin gamma Fc region receptor II-b
K03084  
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K15909  
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
K08091  
growth factor receptor bound protein 2-associated protein 2
K07362  
linker for activation of T cells
K12562  
amphiphysin
K12559  
myosin X
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00219  
Arachidonate
C00416  
Phosphatidate
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C06124  
Sphingosine 1-phosphate
Reference
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
Reference
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
Reference
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
Reference
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
Reference
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
Reference
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
Reference
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
Reference
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
Reference
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
Reference
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
Reference
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
Reference
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
Reference
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
Reference
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
Reference
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
Reference
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)

DBGET integrated database retrieval system