KEGG PATHWAY: ko04728

PATHWAY: ko04728

Entry

ko04728                     Pathway

Name

Dopaminergic synapse

Description

Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.

Class

Organismal Systems; Nervous system

Pathway map

ko04728

Dopaminergic synapse

Other DBs

GO:

0001963

Orthology

K00501

tyrosine 3-monooxygenase [EC:1.14.16.2]

K01593

aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]

K08155

MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2

K04144

dopamine receptor D1

K05840

dopamine receptor D5

K15493

neuron-specific vesicular protein calcyon

K04634

guanine nucleotide-binding protein G(q) subunit alpha

K05858

phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]

K04958

inositol 1,4,5-triphosphate receptor type 1

K04959

inositol 1,4,5-triphosphate receptor type 2

K04960

inositol 1,4,5-triphosphate receptor type 3

K02183

calmodulin

K04515

calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]

K04348

serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]

K02677

classical protein kinase C alpha type [EC:2.7.11.13]

K19662

classical protein kinase C beta type [EC:2.7.11.13]

K19663

classical protein kinase C gamma type [EC:2.7.11.13]

K04379

proto-oncogene protein c-fos

K04632

guanine nucleotide-binding protein G(s) subunit alpha

K04633

guanine nucleotide-binding protein G(olf) subunit alpha

K08045

adenylate cyclase 5 [EC:4.6.1.1]

K04345

protein kinase A [EC:2.7.11.11]

K05870

cyclic AMP-responsive element-binding protein 1

K04450

cyclic AMP-dependent transcription factor ATF-2

K04374

cyclic AMP-dependent transcription factor ATF-4

K09048

cyclic AMP-responsive element-binding protein 3

K09047

cyclic AMP-responsive element-binding protein 5

K09049

cyclic AMP-dependent transcription factor ATF-6 beta

K04441

p38 MAP kinase [EC:2.7.11.24]

K04440

mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]

K15494

protein phosphatase 1 regulatory subunit 1B

K06269

serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]

K04833

voltage-gated sodium channel type I alpha

K04850

voltage-dependent calcium channel L type alpha-1C

K04851

voltage-dependent calcium channel L type alpha-1D

K04344

voltage-dependent calcium channel P/Q type alpha-1A

K04849

voltage-dependent calcium channel N type alpha-1B

K04997

potassium inwardly-rectifying channel subfamily J member 3

K05000

potassium inwardly-rectifying channel subfamily J member 6

K05002

potassium inwardly-rectifying channel subfamily J member 9

K04999

potassium inwardly-rectifying channel subfamily J member 5

K04146

dopamine receptor D3

K04147

dopamine receptor D4

K04630

guanine nucleotide-binding protein G(i) subunit alpha

K04534

guanine nucleotide-binding protein G(o) subunit alpha

K04536

guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

K04537

guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

K07825

guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

K04538

guanine nucleotide-binding protein subunit beta-4

K04539

guanine nucleotide-binding protein subunit beta-5

K07826

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

K04540

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

K04541

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

K04542

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

K04543

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

K04544

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

K04545

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

K04546

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

K04347

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

K04547

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

K04548

guanine nucleotide-binding protein G(T) subunit gamma-T1

K04549

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

K04145

dopamine receptor D2

K04439

beta-arrestin

K04382

serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]

K03456

serine/threonine-protein phosphatase 2A regulatory subunit A

K04354

serine/threonine-protein phosphatase 2A regulatory subunit B

K11583

serine/threonine-protein phosphatase 2A regulatory subunit B''

K11584

serine/threonine-protein phosphatase 2A regulatory subunit B'

K04456

RAC serine/threonine-protein kinase [EC:2.7.11.1]

K08822

glycogen synthase kinase 3 alpha [EC:2.7.11.26]

K03083

glycogen synthase kinase 3 beta [EC:2.7.11.26]

K05209

glutamate receptor ionotropic, NMDA 2A

K05210

glutamate receptor ionotropic, NMDA 2B

K05197

glutamate receptor 1

K05198

glutamate receptor 2

K05199

glutamate receptor 3

K05200

glutamate receptor 4

K10396

kinesin family member 5

K02223

circadian locomoter output cycles kaput protein [EC:2.3.1.48]

K02296

aryl hydrocarbon receptor nuclear translocator-like protein 1

K05036

solute carrier family 6 (neurotransmitter transporter, dopamine) member 3

K00274

monoamine oxidase [EC:1.4.3.4]

K00545

catechol O-methyltransferase [EC:2.1.1.6]

Compound

C00076

Calcium cation

C00082

L-Tyrosine

C00165

Diacylglycerol

C00238

Potassium cation

C00355

3,4-Dihydroxy-L-phenylalanine

C00575

3',5'-Cyclic AMP

C01161

3,4-Dihydroxyphenylacetate

C01245

D-myo-Inositol 1,4,5-trisphosphate

C01330

Sodium cation

C03758

Dopamine

C05582

Homovanillate

C05587

3-Methoxytyramine

Reference

PMID:21303898

Authors

Beaulieu JM, Gainetdinov RR

Title

The physiology, signaling, and pharmacology of dopamine receptors.

Journal

Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642

Reference

PMID:15521361

Authors

Neve KA, Seamans JK, Trantham-Davidson H

Title

Dopamine receptor signaling.

Journal

J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981

Reference

PMID:17408758

Authors

Surmeier DJ, Ding J, Day M, Wang Z, Shen W

Title

D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.

Journal

Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008

Reference

PMID:20224735

Authors

Knab AM, Lightfoot JT

Title

Does the difference between physically active and couch potato lie in the dopamine system?

Journal

Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133

Reference

PMID:10433257

Authors

Greengard P, Allen PB, Nairn AC

Title

Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.

Journal

Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9

Reference

PMID:15590733

Authors

Hu XT, Dong Y, Zhang XF, White FJ

Title

Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.

Journal

J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004

Reference

PMID:17349698

Authors

Beaulieu JM, Gainetdinov RR, Caron MG

Title

The Akt-GSK-3 signaling cascade in the actions of dopamine.

Journal

Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006

Reference

PMID:19138563

Authors

De Mei C, Ramos M, Iitaka C, Borrelli E

Title

Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.

Journal

Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002

Reference

PMID:15381316

Authors

Seamans JK, Yang CR

Title

The principal features and mechanisms of dopamine modulation in the prefrontal cortex.

Journal

Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006

Reference

PMID:18353279

Authors

Yao WD, Spealman RD, Zhang J

Title

Dopaminergic signaling in dendritic spines.

Journal

Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018

Reference

PMID:20727368

Authors

Li YC, Gao WJ

Title

GSK-3beta activity and hyperdopamine-dependent behaviors.

Journal

Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001

Reference

PMID:15292232

Authors

Tang TS, Bezprozvanny I

Title

Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.

Journal

J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200

Reference

PMID:12967774

Authors

Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS

Title

Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.

Journal

Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3

Reference

PMID:9457173

Authors

Missale C, Nash SR, Robinson SW, Jaber M, Caron MG

Title

Dopamine receptors: from structure to function.

Journal

Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189

Reference

PMID:19251795

Authors

Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ

Title

Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?

Journal

Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908

Related
pathway

ko00350

Tyrosine metabolism

ko04020

Calcium signaling pathway

ko04721

Synaptic vesicle cycle

ko04724

Glutamatergic synapse

ko05012

Parkinson disease

All links

Gene (84)   
   KEGG ORTHOLOGY (84)   
All databases (84)   

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