KEGG   PATHWAY: ko04810Help
Entry
ko04810                     Pathway                                

Name
Regulation of actin cytoskeleton
Class
Cellular Processes; Cell motility
BRITE hierarchy
Pathway map
Regulation of actin cytoskeleton
ko04810

All organismsOrtholog table
Disease
H00255  
Hypogonadotropic hypogonadism
H00480  
Non-syndromic X-linked mental retardation
H00484  
Other brachydactylies
H00569  
Aarskog-Scott syndrome
H00578  
MYH9-related kidney diseases
H00586  
Epidermolysis bullosa, junctional
H00590  
Congenital muscular dystrophies (CMD/MDC)
H00626  
Nephrotic syndrome and focal segmental glomerulosclerosis
H00627  
Premature ovarian failure
H00642  
Lacrimo-auriculo-dento-digital syndrome (LADD)
H00698  
Nemaline myopathy
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
H00845  
Familial amyloidosis
H00865  
Lethal congenital contractural syndrome (LCCS)
H00956  
Lattice corneal dystrophies (LCD)
H00957  
Fleck corneal dystrophy (FCD)
H00997  
CATSHL syndrome
H01025  
Familial adenomatous polyposis
H01193  
Familial tumoral calcinosis (FTC)
H01207  
Trigonocephaly
H01255  
Juvenile-onset dystonia
H01260  
Glomerulopathy with fibronectin deposits (GFND)
Other DBs
BSID: 
GO: 
Orthology
K01313  
coagulation factor II (thrombin) [EC:3.4.21.5]
K03914  
coagulation factor II (thrombin) receptor
K04391  
CD14 antigen
K04526  
insulin
K04357  
epidermal growth factor
K18496  
fibroblast growth factor 1
K18497  
fibroblast growth factor 2
K04358  
fibroblast growth factor
K04359  
platelet-derived growth factor subunit A
K17386  
platelet-derived growth factor subunit B
K05450  
platelet derived growth factor C/D
K05086  
insulin receptor-related receptor [EC:2.7.10.1]
K04361  
epidermal growth factor receptor [EC:2.7.10.1]
K04362  
fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093  
fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094  
fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095  
fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04363  
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089  
platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05717  
fibronectin 1
K06480  
integrin alpha 1
K06481  
integrin alpha 2
K06476  
integrin alpha 2B
K06482  
integrin alpha 3
K06483  
integrin alpha 4
K06484  
integrin alpha 5
K06485  
integrin alpha 6
K06583  
integrin alpha 7
K06584  
integrin alpha 8
K06585  
integrin alpha 9
K06586  
integrin alpha 10
K06587  
integrin alpha 11
K06487  
integrin alpha V
K05718  
integrin alpha L
K06461  
integrin alpha M
K06462  
integrin alpha X
K06594  
integrin alpha D
K06524  
integrin alpha E
K05719  
integrin beta 1
K06464  
integrin beta 2
K06493  
integrin beta 3
K06525  
integrin beta 4
K06588  
integrin beta 5
K06589  
integrin beta 6
K06590  
integrin beta 7
K06591  
integrin beta 8
K03915  
bradykinin receptor B1
K03916  
bradykinin receptor B2
K04129  
muscarinic acetylcholine receptor M1
K04130  
muscarinic acetylcholine receptor M2
K04131  
muscarinic acetylcholine receptor M3
K04132  
muscarinic acetylcholine receptor M4
K04133  
muscarinic acetylcholine receptor M5
K04346  
guanine nucleotide-binding protein subunit alpha-12
K04639  
guanine nucleotide-binding protein subunit alpha-13
K04347  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K05720  
FYVE, RhoGEF and PH domain containing 1
K05722  
FYVE, RhoGEF and PH domain containing 3
K05725  
focal adhesion kinase 1 [EC:2.7.10.2]
K05726  
breast cancer anti-estrogen resistance 1
K04438  
proto-oncogene C-crk
K13708  
dedicator of cytokinesis protein 1
K05704  
tyrosine-protein kinase Src [EC:2.7.10.2]
K03099  
son of sevenless
K02833  
GTPase HRas
K07827  
GTPase KRas
K07828  
GTPase NRas
K07829  
Ras-related protein R-Ras
K07830  
Ras-related protein R-Ras2
K07831  
Ras-related protein M-Ras
K05729  
Rho guanine nucleotide exchange factor 6
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649  
phosphoinositide-3-kinase, regulatory subunit
K05730  
guanine nucleotide exchange factor VAV
K05731  
T-lymphoma invasion and metastasis-inducing protein 1
K08845  
A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365  
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04367  
proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K12330  
Rho guanine nucleotide exchange factor 1
K07532  
Rho guanine nucleotide exchange factor 12
K05732  
glucocorticoid receptor DNA-binding factor 1
K04513  
Ras homolog gene family, member A
K04392  
Ras-related C3 botulinum toxin substrate 1
K07860  
Ras-related C3 botulinum toxin substrate 2
K07861  
Ras-related C3 botulinum toxin substrate 3
K04393  
cell division control protein 42
K04409  
p21-activated kinase 1 [EC:2.7.11.1]
K04410  
p21-activated kinase 2 [EC:2.7.11.1]
K05733  
p21-activated kinase 3 [EC:2.7.11.1]
K05734  
p21-activated kinase 4 [EC:2.7.11.1]
K05735  
p21-activated kinase 6 [EC:2.7.11.1]
K05736  
p21-activated kinase 7 [EC:2.7.11.1]
K13710  
Rho guanine nucleotide exchange factor 7
K05737  
G protein-coupled receptor kinase interactor 1
K04514  
Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388  
Rho-associated protein kinase 2 [EC:2.7.11.1]
K00907  
myosin-light-chain kinase [EC:2.7.11.18]
K06269  
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K06270  
protein phosphatase 1 regulatory subunit 12A
K12329  
protein phosphatase 1 regulatory subunit 12B
K17457  
protein phosphatase 1 regulatory subunit 12C
K10351  
myosin regulatory light chain 2
K12753  
myosin regulatory light chain 5
K12754  
myosin regulatory light chain 7
K12755  
myosin regulatory light chain 9
K12756  
myosin regulatory light chain 10
K12757  
myosin regulatory light chain 12
K12758  
fast skeletal myosin light chain 2
K05740  
diaphanous 1
K05741  
diaphanous 2
K05742  
solute carrier family 9 (sodium/hydrogen exchanger), member 1
K00889  
1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K00920  
1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]
K00921  
1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K05743  
LIM domain kinase 1 [EC:2.7.11.1]
K05744  
LIM domain kinase 2 [EC:2.7.11.1]
K05745  
diaphanous 3
K05627  
BAI1-associated protein 2
K05746  
enabled
K05747  
Wiskott-Aldrich syndrome protein
K05748  
WAS protein family, member 2
K05749  
cytoplasmic FMR1 interacting protein
K05750  
NCK-associated protein 1
K05751  
abl interactor 2
K05752  
chromosome 3 open reading frame 10
K05753  
WAS protein family, member 1
K05754  
actin related protein 2/3 complex, subunit 5
K05755  
actin related protein 2/3 complex, subunit 4
K05756  
actin related protein 2/3 complex, subunit 3
K05757  
actin related protein 2/3 complex, subunit 1A/1B
K05758  
actin related protein 2/3 complex, subunit 2
K05692  
actin beta/gamma 1
K05759  
profilin
K05760  
paxillin
K08007  
villin 2 (ezrin)
K05762  
radixin
K05763  
moesin
K05764  
thymosin, beta 4
K05765  
cofilin
K05766  
protein phosphatase slingshot [EC:3.1.3.48 3.1.3.16]
K05700  
vinculin
K16848  
Ras GTPase-activating-like protein IQGAP1
K05767  
Ras GTPase-activating-like protein IQGAP2/3
K05768  
gelsolin
K05699  
actinin alpha
K02085  
adenomatosis polyposis coli protein
K05769  
Rho guanine nucleotide exchange factor 4
Compound
C00306  
Bradykinin
C00338  
Lipopolysaccharide
C01996  
Acetylcholine
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C11554  
1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
Reference
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
Reference
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
Reference
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
Reference
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
Reference
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)

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