KEGG   PATHWAY: ko04810Help
Entry
ko04810                     Pathway                                

Name
Regulation of actin cytoskeleton
Class
Cellular Processes; Cell motility
BRITE hierarchy
Pathway map
ko04810  Regulation of actin cytoskeleton
ko04810

Ortholog table
Disease
H00233  MYH9-related disease
H00255  Hypogonadotropic hypogonadism
H00480  Non-syndromic X-linked mental retardation
H00484  Other brachydactylies
H00505  FGFR3-related short limb skeletal dysplasia
H00569  Aarskog-Scott syndrome
H00578  Epstein syndrome
H00586  Epidermolysis bullosa, junctional
H00590  Congenital muscular dystrophies (CMD/MDC)
H00627  Premature ovarian failure
H00642  Lacrimo-auriculo-dento-digital syndrome (LADD)
H00698  Nemaline myopathy
H00801  Familial thoracic aortic aneurysm and dissection (TAAD)
H00845  Familial amyloidosis
H00956  Lattice corneal dystrophies (LCD)
H00957  Fleck corneal dystrophy (FCD)
H00997  CATSHL syndrome
H01025  Familial adenomatous polyposis
H01193  Familial tumoral calcinosis (FTC)
H01207  Trigonocephaly
H01255  Juvenile-onset dystonia
H01260  Glomerulopathy with fibronectin deposits (GFND)
H01523  Wiskott-Aldrich syndrome
H01740  Macrothrombocytopenia
H02023  Baraitser-Winter syndrome
H02051  May-Hegglin anomaly
H02053  Fechtner syndrome
H02068  Hypochondroplasia
H02069  SADDAN
Other DBs
BSID: 500
GO: 0030036
Orthology
K01313  coagulation factor II (thrombin) [EC:3.4.21.5]
K03914  coagulation factor II (thrombin) receptor
K04391  monocyte differentiation antigen CD14
K04526  insulin
K04357  epidermal growth factor
K18496  fibroblast growth factor 1
K18497  fibroblast growth factor 2
K04358  fibroblast growth factor
K22603  fibroblast growth factor 19
K22429  fibroblast growth factor 21
K22428  fibroblast growth factor 23
K04359  platelet-derived growth factor subunit A
K17386  platelet-derived growth factor subunit B
K05450  platelet derived growth factor C/D
K05086  insulin receptor-related receptor [EC:2.7.10.1]
K04361  epidermal growth factor receptor [EC:2.7.10.1]
K04362  fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093  fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094  fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095  fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04363  platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089  platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05717  fibronectin 1
K06480  integrin alpha 1
K06481  integrin alpha 2
K06476  integrin alpha 2B
K06482  integrin alpha 3
K06483  integrin alpha 4
K06484  integrin alpha 5
K06485  integrin alpha 6
K06583  integrin alpha 7
K06584  integrin alpha 8
K06585  integrin alpha 9
K06586  integrin alpha 10
K06587  integrin alpha 11
K06487  integrin alpha V
K05718  integrin alpha L
K06461  integrin alpha M
K06462  integrin alpha X
K06594  integrin alpha D
K06524  integrin alpha E
K05719  integrin beta 1
K06464  integrin beta 2
K06493  integrin beta 3
K06525  integrin beta 4
K06588  integrin beta 5
K06589  integrin beta 6
K06590  integrin beta 7
K06591  integrin beta 8
K03915  bradykinin receptor B1
K03916  bradykinin receptor B2
K04129  muscarinic acetylcholine receptor M1
K04130  muscarinic acetylcholine receptor M2
K04131  muscarinic acetylcholine receptor M3
K04132  muscarinic acetylcholine receptor M4
K04133  muscarinic acetylcholine receptor M5
K04346  guanine nucleotide-binding protein subunit alpha-12
K04639  guanine nucleotide-binding protein subunit alpha-13
K04347  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K05720  FYVE, RhoGEF and PH domain containing 1
K05722  FYVE, RhoGEF and PH domain containing 3
K05725  focal adhesion kinase 1 [EC:2.7.10.2]
K05726  breast cancer anti-estrogen resistance 1
K04438  proto-oncogene C-crk
K13708  dedicator of cytokinesis protein 1
K05704  tyrosine-protein kinase Src [EC:2.7.10.2]
K03099  son of sevenless
K02833  GTPase HRas
K07827  GTPase KRas
K07828  GTPase NRas
K07829  Ras-related protein R-Ras
K07830  Ras-related protein R-Ras2
K07831  Ras-related protein M-Ras
K05729  Rho guanine nucleotide exchange factor 6
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K05730  guanine nucleotide exchange factor VAV
K05731  T-lymphoma invasion and metastasis-inducing protein 1
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04367  proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K12330  Rho guanine nucleotide exchange factor 1
K07532  Rho guanine nucleotide exchange factor 12
K05732  glucocorticoid receptor DNA-binding factor 1
K04513  Ras homolog gene family, member A
K04392  Ras-related C3 botulinum toxin substrate 1
K07860  Ras-related C3 botulinum toxin substrate 2
K07861  Ras-related C3 botulinum toxin substrate 3
K04393  cell division control protein 42
K04409  p21-activated kinase 1 [EC:2.7.11.1]
K04410  p21-activated kinase 2 [EC:2.7.11.1]
K05733  p21-activated kinase 3 [EC:2.7.11.1]
K05734  p21-activated kinase 4 [EC:2.7.11.1]
K05736  p21-activated kinase 5 [EC:2.7.11.1]
K05735  p21-activated kinase 6 [EC:2.7.11.1]
K13710  Rho guanine nucleotide exchange factor 7
K05737  G protein-coupled receptor kinase interactor 1
K04514  Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388  Rho-associated protein kinase 2 [EC:2.7.11.1]
K00907  myosin-light-chain kinase [EC:2.7.11.18]
K06269  serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K06270  protein phosphatase 1 regulatory subunit 12A
K12329  protein phosphatase 1 regulatory subunit 12B
K17457  protein phosphatase 1 regulatory subunit 12C
K10351  myosin regulatory light chain 2
K12753  myosin regulatory light chain 5
K12754  myosin regulatory light chain 7
K12755  myosin regulatory light chain 9
K12756  myosin regulatory light chain 10
K12757  myosin regulatory light chain 12
K12758  fast skeletal myosin light chain 2
K05740  diaphanous 1
K05741  diaphanous 2
K05742  solute carrier family 9 (sodium/hydrogen exchanger), member 1
K00889  1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K00920  1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]
K00921  1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K05743  LIM domain kinase 1 [EC:2.7.11.1]
K05744  LIM domain kinase 2 [EC:2.7.11.1]
K05745  diaphanous 3
K05627  BAI1-associated protein 2
K05746  enabled
K05747  Wiskott-Aldrich syndrome protein
K05748  WAS protein family, member 2
K05749  cytoplasmic FMR1 interacting protein
K05750  NCK-associated protein 1
K05751  abl interactor 2
K05752  chromosome 3 open reading frame 10
K05753  WAS protein family, member 1
K05754  actin related protein 2/3 complex, subunit 5
K05755  actin related protein 2/3 complex, subunit 4
K05756  actin related protein 2/3 complex, subunit 3
K05757  actin related protein 2/3 complex, subunit 1A/1B
K05758  actin related protein 2/3 complex, subunit 2
K05692  actin beta/gamma 1
K05759  profilin
K05760  paxillin
K08007  villin 2 (ezrin)
K05762  radixin
K05763  moesin
K05764  thymosin, beta 4
K05765  cofilin
K05766  protein phosphatase slingshot [EC:3.1.3.48 3.1.3.16]
K05700  vinculin
K16848  Ras GTPase-activating-like protein IQGAP1
K05767  Ras GTPase-activating-like protein IQGAP2/3
K05768  gelsolin
K05699  actinin alpha 1/4
K02085  adenomatosis polyposis coli protein
K05769  Rho guanine nucleotide exchange factor 4/29
Compound
C00306  Bradykinin
C00338  Lipopolysaccharide
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
Reference
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)

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