KEGG   PATHWAY: ko04914Help
ko04914                     Pathway                                

Progesterone-mediated oocyte maturation
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
ko04914  Progesterone-mediated oocyte maturation

Ortholog table
M00389  APC/C complex [PATH:ko04914]
H01274  Growth delay due to insulin-like growth factor I resistance
D02840  Altrenogest (USAN/INN)
Other DBs
BSID: 503
GO: 0001556
K08556  progesterone receptor
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:]
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:]
K04441  p38 MAP kinase [EC:]
K04630  guanine nucleotide-binding protein G(i) subunit alpha
K08041  adenylate cyclase 1 [EC:]
K08042  adenylate cyclase 2 [EC:]
K08043  adenylate cyclase 3 [EC:]
K08044  adenylate cyclase 4 [EC:]
K08045  adenylate cyclase 5 [EC:]
K08046  adenylate cyclase 6 [EC:]
K08047  adenylate cyclase 7 [EC:]
K08048  adenylate cyclase 8 [EC:]
K08049  adenylate cyclase 9 [EC:]
K04345  protein kinase A [EC:]
K11481  aurora kinase A [EC:]
K02602  cytoplasmic polyadenylation element-binding protein
K08694  speedy
K02206  cyclin-dependent kinase 2 [EC:]
K02087  cyclin-dependent kinase 1 [EC:]
K06627  cyclin-A
K04367  proto-oncogene serine/threonine-protein kinase mos [EC:]
K04079  molecular chaperone HtpG
K04368  mitogen-activated protein kinase kinase 1 [EC:]
K04371  mitogen-activated protein kinase 1/3 [EC:]
K04373  ribosomal protein S6 kinase alpha-1/2/3/6 [EC:]
K06633  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:]
K05868  G2/mitotic-specific cyclin-B1
K21770  G2/mitotic-specific cyclin-B2
K21771  G2/mitotic-specific cyclin-B3
K08837  serine/threonine kinase 10 [EC:]
K06631  polo-like kinase 1 [EC:]
K06645  M-phase inducer phosphatase 1 [EC:]
K05866  M-phase inducer phosphatase 2 [EC:]
K05867  M-phase inducer phosphatase 3 [EC:]
K04526  insulin
K05459  insulin-like growth factor 1
K05087  insulin-like growth factor 1 receptor [EC:]
K04456  RAC serine/threonine-protein kinase [EC:]
K13296  cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:]
K07827  GTPase KRas
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:]
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:]
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:]
K02178  checkpoint serine/threonine-protein kinase [EC:]
K06638  mitotic spindle assembly checkpoint protein MAD1
K02537  mitotic spindle assembly checkpoint protein MAD2
K13728  mitotic spindle assembly checkpoint protein MAD2B
K03364  cell division cycle 20-like protein 1, cofactor of APC complex
K03348  anaphase-promoting complex subunit 1
K03349  anaphase-promoting complex subunit 2
K03350  anaphase-promoting complex subunit 3
K03351  anaphase-promoting complex subunit 4
K03352  anaphase-promoting complex subunit 5
K03353  anaphase-promoting complex subunit 6
K03354  anaphase-promoting complex subunit 7
K03355  anaphase-promoting complex subunit 8
K03356  anaphase-promoting complex subunit 9
K03357  anaphase-promoting complex subunit 10
K03358  anaphase-promoting complex subunit 11
K03359  anaphase-promoting complex subunit 12
K12456  anaphase-promoting complex subunit 13
K10403  kinesin family member 22
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Schmitt A, Nebreda AR.
Signalling pathways in oocyte meiotic maturation.
J Cell Sci 115:2457-9 (2002)
Cato AC, Nestl A, Mink S.
Rapid actions of steroid receptors in cellular signaling pathways.
Sci STKE 2002:RE9 (2002)
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Biol Cell 93:27-33 (2001)
Nebreda AR, Ferby I.
Regulation of the meiotic cell cycle in oocytes.
Curr Opin Cell Biol 12:666-75 (2000)
Ferrell JE Jr.
Xenopus oocyte maturation: new lessons from a good egg.
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Biochem J 369:227-38 (2003)
Duckworth BC, Weaver JS, Ruderman JV.
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Proc Natl Acad Sci U S A 99:16794-9 (2002)
Abrieu A, Doree M, Fisher D.
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
J Cell Sci 114:257-67 (2001)

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