KEGG   PATHWAY: ko04914Help
Entry
ko04914                     Pathway                                

Name
Progesterone-mediated oocyte maturation
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Progesterone-mediated oocyte maturation
ko04914

All organismsOrtholog table
Module
M00389  
APC/C complex [PATH:ko04914]
Disease
H01274  
Growth delay due to insulin-like growth factor I resistance
Drug
D02840  
Altrenogest (USAN/INN)
Other DBs
BSID: 
GO: 
Orthology
K08556  
progesterone receptor
K02649  
phosphoinositide-3-kinase, regulatory subunit
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K04440  
c-Jun N-terminal kinase [EC:2.7.11.24]
K04441  
p38 MAP kinase [EC:2.7.11.24]
K04630  
guanine nucleotide-binding protein G(i) subunit alpha
K08041  
adenylate cyclase 1 [EC:4.6.1.1]
K08042  
adenylate cyclase 2 [EC:4.6.1.1]
K08043  
adenylate cyclase 3 [EC:4.6.1.1]
K08044  
adenylate cyclase 4 [EC:4.6.1.1]
K08045  
adenylate cyclase 5 [EC:4.6.1.1]
K08046  
adenylate cyclase 6 [EC:4.6.1.1]
K08047  
adenylate cyclase 7 [EC:4.6.1.1]
K08048  
adenylate cyclase 8 [EC:4.6.1.1]
K08049  
adenylate cyclase 9 [EC:4.6.1.1]
K04345  
protein kinase A [EC:2.7.11.11]
K02602  
cytoplasmic polyadenylation element-binding protein
K08694  
speedy
K02206  
cyclin-dependent kinase 2 [EC:2.7.11.22]
K02087  
cyclin-dependent kinase 1 [EC:2.7.11.23 2.7.11.22]
K06627  
cyclin A
K04367  
proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
K04079  
molecular chaperone HtpG
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04373  
p90 ribosomal S6 kinase [EC:2.7.11.1]
K06633  
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]
K05868  
cyclin B
K06631  
polo-like kinase 1 [EC:2.7.11.21]
K06645  
M-phase inducer phosphatase 1 [EC:3.1.3.48]
K05866  
M-phase inducer phosphatase 2 [EC:3.1.3.48]
K05867  
M-phase inducer phosphatase 3 [EC:3.1.3.48]
K04526  
insulin
K05459  
insulin-like growth factor 1
K05087  
insulin-like growth factor 1 receptor [EC:2.7.10.1]
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
K13296  
cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
K07827  
GTPase KRas
K08845  
A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365  
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K02178  
checkpoint serine/threonine-protein kinase [EC:2.7.11.1]
K06638  
mitotic spindle assembly checkpoint protein MAD1
K02537  
mitotic spindle assembly checkpoint protein MAD2
K13728  
mitotic spindle assembly checkpoint protein MAD2B
K03364  
cell division cycle 20-like protein 1, cofactor of APC complex
K03348  
anaphase-promoting complex subunit 1
K03349  
anaphase-promoting complex subunit 2
K03350  
anaphase-promoting complex subunit 3
K03351  
anaphase-promoting complex subunit 4
K03352  
anaphase-promoting complex subunit 5
K03353  
anaphase-promoting complex subunit 6
K03354  
anaphase-promoting complex subunit 7
K03355  
anaphase-promoting complex subunit 8
K03356  
anaphase-promoting complex subunit 9
K03357  
anaphase-promoting complex subunit 10
K03358  
anaphase-promoting complex subunit 11
K03359  
anaphase-promoting complex subunit 12
K12456  
anaphase-promoting complex subunit 13
Compound
C00410  
Progesterone
C00575  
3',5'-Cyclic AMP
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C11554  
1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
Reference
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
Reference
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
Reference
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
Reference
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
Reference
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
Reference
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)

DBGET integrated database retrieval system