KEGG   PATHWAY: ko05100Help
Entry
ko05100                     Pathway                                

Name
Bacterial invasion of epithelial cells
Description
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Bacterial invasion of epithelial cells
ko05100

All organismsOrtholog table
Orthology
K13730  
internalin A
K13731  
internalin B
K13732  
fibronectin-binding protein A
K13733  
fibronectin-binding protein B
K13925  
plasmin and fibronectin-binding protein A
K13734  
fibronectin-binding protein 1
K13735  
adhesin/invasin
K05689  
cadherin 1, type 1, E-cadherin
K02105  
catenin beta 1
K05691  
catenin alpha
K13736  
Rho GTPase-activating protein 10
K05099  
proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K09593  
GRB2-associated-binding protein 1
K02649  
phosphoinositide-3-kinase, regulatory subunit
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K04438  
proto-oncogene C-crk
K13708  
dedicator of cytokinesis protein 1
K04393  
cell division control protein 42
K04392  
Ras-related C3 botulinum toxin substrate 1
K05747  
Wiskott-Aldrich syndrome protein
K05753  
WAS protein family, member 1
K05748  
WAS protein family, member 2
K05757  
actin related protein 2/3 complex, subunit 1A/1B
K05758  
actin related protein 2/3 complex, subunit 2
K05756  
actin related protein 2/3 complex, subunit 3
K05755  
actin related protein 2/3 complex, subunit 4
K05754  
actin related protein 2/3 complex, subunit 5
K05692  
actin beta/gamma 1
K13737  
septin 1
K16942  
septin 2
K16938  
septin 3/9/12
K16939  
septin 6/8/11
K04707  
E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
K06279  
SHC- transforming protein 1
K17447  
SHC- transforming protein 2
K17448  
SHC- transforming protein 3
K17449  
SHC- transforming protein 4
K13738  
CD2-associated protein
K01528  
dynamin GTPase [EC:3.6.5.5]
K04644  
clathrin light chain A
K04645  
clathrin light chain B
K04646  
clathrin heavy chain
K06278  
caveolin 1
K12958  
caveolin 2
K12959  
caveolin 3
K06106  
cortactin
K05704  
tyrosine-protein kinase Src [EC:2.7.10.2]
K05725  
focal adhesion kinase 1 [EC:2.7.10.2]
K05726  
breast cancer anti-estrogen resistance 1
K05760  
paxillin
K05717  
fibronectin 1
K06484  
integrin alpha 5
K05719  
integrin beta 1
K06272  
integrin-linked kinase [EC:2.7.11.1]
K13287  
invasin D
K13286  
invasin C
K13285  
invasin B
K13739  
secreted effector protein SopD
K13284  
invasin A
K13740  
secreted effector protein SptP
K13741  
guanine nucleotide exchange factor SopE
K13085  
phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
K13742  
protein IpgB1
K13743  
protein IpgB2
K12785  
LEE-encoded effector EspG
K13728  
mitotic spindle assembly checkpoint protein MAD2B
K13744  
SH3 domain-containing guanine exchange factor
K07863  
Ras homolog gene family, member G
K12366  
engulfment and cell motility protein 1
K04513  
Ras homolog gene family, member A
K05700  
vinculin
Reference
  Authors
Mostowy S, Cossart P
  Title
Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
  Journal
Cell Motil Cytoskeleton 66:816-23 (2009)
Reference
  Authors
Hauck CR, Ohlsen K
  Title
Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
  Journal
Curr Opin Microbiol 9:5-11 (2006)
Reference
  Authors
Wang B, Li S, Dedhar S, Cleary PP
  Title
Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase  (ILK) in streptococcal invasion.
  Journal
Cell Microbiol 9:1519-28 (2007)
Reference
  Authors
Matsumoto H, Young GM
  Title
Translocated effectors of Yersinia.
  Journal
Curr Opin Microbiol 12:94-100 (2009)
Reference
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
Reference
  Authors
Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
  Title
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
  Journal
Cell 130:611-23 (2007)
Reference
  Authors
Ohno H, Yoshimori T (eds).
  Title
[Current Stream in Membrane Traffic] (in Japanese)
  Journal
Tanpakushitsu Kakusan Koso 53 (2008)

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