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Entry
ko05130                     Pathway                                

Name
Pathogenic Escherichia coli infection
Description
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Pathogenic Escherichia coli infection
ko05130

All organismsOrtholog table
Module
M00363  
EHEC pathogenicity signature, Shiga toxin [PATH:ko05130]
M00542  
EHEC/EPEC pathogenicity signature, T3SS and effectors [PATH:ko05130]
Disease
H00277  
Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  
Enteropathogenic Escherichia coli (EPEC) infection
Orthology
K11006  
shiga toxin subunit A
K11007  
shiga toxin subunit B
K12784  
translocated intimin receptor
K12785  
LEE-encoded effector EspG
K12786  
LEE-encoded effector EspF
K12787  
LEE-encoded effector Map
K12788  
LEE-encoded effector EspH
K12809  
T3SS secreted effector EspG-like protein
K16041  
non-LEE-encoded effector NleA
K16042  
non-LEE-encoded effector NleH
K12789  
Tir-cytoskeleton coupling protein
K12810  
major structural subunit of bundle-forming pilus
K12790  
intimin
K10168  
toll-like receptor 5
K04391  
CD14 antigen
K10160  
toll-like receptor 4
K05400  
lymphocyte antigen 96
K07374  
tubulin alpha
K07375  
tubulin beta
K12791  
Rho guanine nucleotide exchange factor 2
K04513  
Ras homolog gene family, member A
K04514  
Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388  
Rho-associated protein kinase 2 [EC:2.7.11.1]
K07365  
NCK adaptor protein
K05747  
Wiskott-Aldrich syndrome protein
K05757  
actin related protein 2/3 complex, subunit 1A/1B
K05758  
actin related protein 2/3 complex, subunit 2
K05756  
actin related protein 2/3 complex, subunit 3
K05755  
actin related protein 2/3 complex, subunit 4
K05754  
actin related protein 2/3 complex, subunit 5
K05692  
actin beta/gamma 1
K05703  
tyrosine-protein kinase Fyn [EC:2.7.10.2]
K06619  
abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K06106  
cortactin
K11294  
nucleolin
K05719  
integrin beta 1
K04393  
cell division control protein 42
K06088  
occludin
K08007  
villin 2 (ezrin)
K05689  
cadherin 1, type 1, E-cadherin
K02105  
catenin beta 1
Compound
C00350  
Phosphatidylethanolamine
Reference
  Authors
Kaper JB, Nataro JP, Mobley HL.
  Title
Pathogenic Escherichia coli.
  Journal
Nat Rev Microbiol 2:123-40 (2004)
Reference
  Authors
Torres AG, Zhou X, Kaper JB.
  Title
Adherence of diarrheagenic Escherichia coli strains to epithelial cells.
  Journal
Infect Immun 73:18-29 (2005)
Reference
  Authors
Dean P, Maresca M, Kenny B.
  Title
EPEC's weapons of mass subversion.
  Journal
Curr Opin Microbiol 8:28-34 (2005)
Reference
  Authors
Garmendia J, Frankel G, Crepin VF.
  Title
Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation.
  Journal
Infect Immun 73:2573-85 (2005)
Reference
  Authors
Spears KJ, Roe AJ, Gally DL.
  Title
A comparison of enteropathogenic and enterohaemorrhagic Escherichia coli pathogenesis.
  Journal
FEMS Microbiol Lett 255:187-202 (2006)
Reference
  Authors
Kenny B.
  Title
Enteropathogenic Escherichia coli (EPEC)-- a crafty subversive little bug.
  Journal
Microbiology 148:1967-78 (2002)
Reference
  Authors
Hayward RD, Leong JM, Koronakis V, Campellone KG.
  Title
Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling.
  Journal
Nat Rev Microbiol 4:358-70 (2006)
Reference
  Authors
Matsuzawa T, Kuwae A, Yoshida S, Sasakawa C, Abe A.
  Title
Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.
  Journal
EMBO J 23:3570-82 (2004)
Reference
  Authors
Dean P, Kenny B
  Title
The effector repertoire of enteropathogenic E. coli: ganging up on the host cell.
  Journal
Curr Opin Microbiol 12:101-9 (2009)

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