KEGG   ORTHOLOGY: K00025Help
Entry
K00025                      KO                                     
Name
MDH1
Definition
malate dehydrogenase [EC:1.1.1.37]
Pathway
Citrate cycle (TCA cycle)
Pyruvate metabolism
Glyoxylate and dicarboxylate metabolism
Carbon fixation in photosynthetic organisms
Proximal tubule bicarbonate reclamation
Module
M00009  
Citrate cycle (TCA cycle, Krebs cycle)
M00011  
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00012  
Glyoxylate cycle
M00168  
CAM (Crassulacean acid metabolism), dark
M00171  
C4-dicarboxylic acid cycle, NAD+ -malic enzyme type
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00025  MDH1; malate dehydrogenase
   00620 Pyruvate metabolism
    K00025  MDH1; malate dehydrogenase
   00630 Glyoxylate and dicarboxylate metabolism
    K00025  MDH1; malate dehydrogenase
  Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K00025  MDH1; malate dehydrogenase
 Organismal Systems
  Excretory system
   04964 Proximal tubule bicarbonate reclamation
    K00025  MDH1; malate dehydrogenase
KEGG pathway modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Carbon fixation
    M00168  CAM (Crassulacean acid metabolism), dark
     K00025  MDH1; malate dehydrogenase
    M00171  C4-dicarboxylic acid cycle, NAD+ -malic enzyme type
     K00025  MDH1; malate dehydrogenase
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00009  Citrate cycle (TCA cycle, Krebs cycle)
     K00025  MDH1; malate dehydrogenase
    M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
     K00025  MDH1; malate dehydrogenase
   Other carbohydrate metabolism
    M00012  Glyoxylate cycle
     K00025  MDH1; malate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.37  malate dehydrogenase
     K00025  MDH1; malate dehydrogenase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
4190(MDH1)
PTR: 
459271(MDH1)
PPS: 
100977785(MDH1)
GGO: 
101134761(MDH1)
PON: 
100454132(MDH1)
MCC: 
694703(MDH1)
MMU: 
17449(Mdh1)
RNO: 
24551(Mdh1)
CFA: 
474614(MDH1)
AML: 
FCA: 
493924(MDH1)
BTA: 
535182(MDH1)
SSC: 
396894(MDH1)
ECB: 
100051612
MDO: 
100031872
SHR: 
100925139(MDH1)
OAA: 
100082315(MDH1)
GGA: 
421281(MDH1)
MGP: 
100539955
TGU: 
100190381
ACS: 
100553622
XLA: 
398872(mdh1)
XTR: 
448318(mdh1)
DRE: 
335715(mdh1b) 399662(mdh1a)
TRU: 
101072315 101073761
OLA: 
100049475(mdhb) 100302445(mdha)
BFO: 
BRAFLDRAFT_81385
CIN: 
100187217
SPU: 
591635
DME: 
Dmel_CG5362(Mdh1)
DAN: 
Dana_GF14102
DER: 
Dere_GG23937
DPE: 
Dper_GL19158
DSE: 
Dsec_GM11692
DSI: 
Dsim_GD22263
DWI: 
Dwil_GK23502
DYA: 
Dyak_GE25998
DGR: 
Dgri_GH13357
DMO: 
Dmoj_GI18261
DVI: 
Dvir_GJ17520
AGA: 
AgaP_AGAP009510
AAG: 
AaeL_AAEL007707
CQU: 
CpipJ_CPIJ002460
AME: 
411014 552575
NVI: 
100119291(NV16898)
TCA: 
664447
API: 
100163431
PHU: 
Phum_PHUM154200
ISC: 
IscW_ISCW007624
CEL: 
CELE_F46E10.10(mdh-1)
CBR: 
CBG18957
BMY: 
Bm1_04060
TSP: 
Tsp_08379
SMM: 
Smp_035270.1 Smp_035270.2
NVE: 
NEMVE_v1g185681
HMG: 
100208718
TAD: 
TRIADDRAFT_63987
AQU: 
100639823
ATH: 
AT1G04410 AT5G43330 AT5G56720
ALY: 
ARALYDRAFT_331971 ARALYDRAFT_470418 ARALYDRAFT_494670
GMX: 
100783188 100811402 547963
MTR: 
MTR_1g043040 MTR_8g005980
CSV: 
101204387 101221189
RCU: 
RCOM_0400230 RCOM_0400340 RCOM_1609380
POP: 
POPTR_551994 POPTR_551996 POPTR_564942 POPTR_747123
VVI: 
100248145 100253273 100256452
OSA: 
4336595 4348905
DOSA: 
Os04t0551200-01(Os04g0551200) Os10t0478200-01(Os10g0478200)
BDI: 
100822821 100841049
SBI: 
SORBI_01g019280(SORBIDRAFT_01g019280) SORBI_06g024610(SORBIDRAFT_06g024610)
ZMA: 
100280767 542598(mdh5)
SMO: 
SELMODRAFT_269798 SELMODRAFT_271992
PPP: 
PHYPADRAFT_195276
CRE: 
CHLREDRAFT_158129(MDH3)
VCN: 
VOLCADRAFT_109769
OLU: 
OSTLU_87414
OTA: 
Ot06g00180
CME: 
CMP193C CMT611C
MBR: 
MONBRDRAFT_15806
NGR: 
NAEGRDRAFT_83065
DDI: 
DDB_G0280255(mdhC) DDB_G0290207(mdhA) DDB_G0292600(mdhB)
DPP: 
DICPUDRAFT_76668 DICPUDRAFT_91907
EHI: 
EHI_030810(195.t00006) EHI_152670(24.t00003)
EDI: 
EDI_082420 EDI_092900
TET: 
TTHERM_00030190 TTHERM_00052260 TTHERM_00237500
PTM: 
GSPATT00028542001 GSPATT00033909001 GSPATT00036328001
TBR: 
Tb11.01.3040
TCR: 
506937.10 510437.40
LMA: 
LMJF_28_2860(cMDH)
LIF: 
LINJ_28_3090(cMDH)
LDO: 
LDBPK_283090
LMI: 
LMXM_28_2860
LBZ: 
LBRM_28_3070(cMDH)
GLA: 
GL50803_3331
TVA: 
TVAG_171090 TVAG_171100 TVAG_193000 TVAG_204360 TVAG_354940 TVAG_381310 TVAG_534540
TPS: 
THAPS_41425
PIF: 
PITG_15476
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Minarik P, Tomaskova N, Kollarova M, Antalik M
  Title
Malate dehydrogenases--structure and function.
  Journal
Gen Physiol Biophys 21:257-65 (2002)
Reference
PMID:7849603
  Authors
Goward CR, Nicholls DJ
  Title
Malate dehydrogenase: a model for structure, evolution, and catalysis.
  Journal
Protein Sci 3:1883-8 (1994)
Reference
  Authors
Madern D
  Title
Molecular evolution within the L-malate and L-lactate dehydrogenase super-family.
  Journal
J Mol Evol 54:825-40 (2002)
DBGET integrated database retrieval system