KEGG ORTHOLOGY: K00294

ORTHOLOGY: K00294

Entry

K00294 KO

Name

E1.5.1.12

Definition

1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.1.12]

Pathway

ko00250	Alanine, aspartate and glutamate metabolism
ko00330	Arginine and proline metabolism

Disease

H00190

Hyperprolinemia (HP)

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K00294  E1.5.1.12; 1-pyrroline-5-carboxylate dehydrogenase
   00330 Arginine and proline metabolism
    K00294  E1.5.1.12; 1-pyrroline-5-carboxylate dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.12  1-pyrroline-5-carboxylate dehydrogenase
     K00294  E1.5.1.12; 1-pyrroline-5-carboxylate dehydrogenase

Other DBs

RN:

R00245 R00707 R00708 R04444 R04445 R05051

COG:

COG1012

GO:

0003842

Genes

HSA:	8659(ALDH4A1)
PTR:	456575(ALDH4A1)
PPS:	100984082(ALDH4A1)
GGO:	101136541(ALDH4A1)
PON:	100172770(ALDH4A1)
MCC:	714870
MMU:	212647(Aldh4a1)
RNO:	641316(Aldh4a1)
CFA:	612452(ALDH4A1)
AML:	100476799
FCA:	101089025(ALDH4A1)
BTA:	100126042(ALDH4A1)
SSC:	100820830(ALDH4A1)
ECB:	100147246(ALDH4A1)
MDO:	100619338
SHR:	100918204(ALDH4A1)
OAA:	100085911 100092834
GGA:	419467(ALDH4A1)
MGP:	100549949
XLA:	100036784(aldh4a1)
XTR:	100124732(aldh4a1)
DRE:	394133(aldh4a1)
TRU:	101072521 101072754
OLA:	101160805
BFO:	BRAFLDRAFT_214534
CIN:	100179556
SPU:	576807
DME:	Dmel_CG6661 Dmel_CG7145(P5CDh1)
DPO:	Dpse_GA20135
DAN:	Dana_GF23503
DER:	Dere_GG13195
DPE:	Dper_GL25324
DSE:	Dsec_GM22106
DSI:	Dsim_GD17558
DWI:	Dwil_GK12188 Dwil_GK17042
DYA:	Dyak_GE19517
DGR:	Dgri_GH17138
DMO:	Dmoj_GI11746
DVI:	Dvir_GJ13456
AGA:	AgaP_AGAP004366
AAG:	AaeL_AAEL005422
CQU:	CpipJ_CPIJ007660
AME:	551113
NVI:	100116896(NV13117)
TCA:	657887
API:	100165747
PHU:	Phum_PHUM048020
ISC:	IscW_ISCW015982
CEL:	CELE_F56D12.1(alh-6)
CBR:	CBG07110(Cbr-alh-6)
BMY:	Bm1_04205
SMM:	Smp_065060
NVE:	NEMVE_v1g186547
HMG:	100211627
TAD:	TRIADDRAFT_26837
AQU:	100641410
ATH:	AT5G62530(ALDH12A1)
ALY:	ARALYDRAFT_496432
GMX:	100794466 100806579 100813821
MTR:	MTR_4g107940
CSV:	101214440
RCU:	RCOM_1513940
POP:	POPTR_581353
VVI:	100251938
DOSA:	Os05t0536400-01(Os05g0536400)
BDI:	100831540
SBI:	SORBI_09g026810(SORBIDRAFT_09g026810)
SMO:	SELMODRAFT_184908 SELMODRAFT_90262
PPP:	PHYPADRAFT_207743(ALDH12A)
CRE:	CHLREDRAFT_150809(ALD1)
VCN:	VOLCADRAFT_69010(ald1)
OLU:	OSTLU_30910
OTA:	Ot03g05840
CME:	CMG200C
SCE:	YHR037W(PUT2)
AGO:	AGOS_AAL071C
ERC:	Ecym_3187
KLA:	KLLA0C10549g
LTH:	KLTH0G06226g
PPA:	PAS_chr2-2_0496
VPO:	Kpol_1023p49
ZRO:	ZYRO0G16874g
CGR:	CAGL0D03982g
NCS:	NCAS_0A01390(NCAS0A01390)
NDI:	NDAI_0C02190(NDAI0C02190)
TPF:	TPHA_0E01370(TPHA0E01370)
TBL:	TBLA_0C03290(TBLA0C03290)
TDL:	TDEL_0E03190(TDEL0E03190)
KAF:	KAFR_0J00360(KAFR0J00360)
DHA:	DEHA2G20482g
PIC:	PICST_55391(PUT2)
PGU:	PGUG_03032
LEL:	LELG_03981
CAL:	CaO19.11457(PUT2) CaO19.3974(PUT2)
CTP:	CTRG_06088
CDU:	CD36_54480
COT:	CORT_0F01570
YLI:	YALI0B09647g
CLU:	CLUG_01816
NCR:	NCU03076
SMP:	SMAC_02805
PAN:	PODANSg5887
TTT:	THITE_2170138
MTM:	MYCTH_2296305
MGR:	MGG_17513
FGR:	FG01141.1 FG03073.1
NHE:	NECHADRAFT_75603 NECHADRAFT_98405 NECHADRAFT_98739
VAL:	VDBG_06058 VDBG_06354
SSL:	SS1G_01099
BFU:	BC1G_12887
ANI:	AN1733.2 AN6022.2
NFI:	NFIA_054400
AFM:	AFUA_6G08750
AOR:	AOR_1_968164(AO090001000549)
ANG:	ANI_1_1774064(An07g05000) ANI_1_2324024(An02g02290) ANI_1_814094(An11g06140)
AFV:	AFLA_018620 AFLA_072770 AFLA_114320 AFLA_114330 AFLA_128530
ACT:	ACLA_083660
PCS:	Pc12g08900 Pc13g01370 Pc21g19920
CIM:	CIMG_06927
CPW:	CPC735_033140
PBL:	PAAG_05253
URE:	UREG_05921
ABE:	ARB_02852
TVE:	TRV_03380 TRV_05545
AJE:	HCAG_01780 HCAG_09000
PNO:	SNOG_06725
PTE:	PTT_13363
ZTR:	MYCGRDRAFT_67317
TML:	GSTUM_00003489001
SPO:	SPBC24C6.04
CNE:	CNH02450
CNB:	CNBL2470
CGI:	CGB_L3110W
PPL:	POSPLDRAFT_99259
LBC:	LACBIDRAFT_188701
MPR:	MPER_10681
CCI:	CC1G_10646
SCM:	SCHCODRAFT_71606
UMA:	UM01250.1
MGL:	MGL_2090
PGR:	PGTG_14723
NGR:	NAEGRDRAFT_32733
DDI:	DDB_G0283293
DPP:	DICPUDRAFT_47368
TGO:	TGME49_088450
TET:	TTHERM_00822160
PTM:	GSPATT00008519001 GSPATT00010303001 GSPATT00012906001
TBR:	Tb10.70.4280
TCR:	510943.50
LIF:	LINJ_03_0190
LDO:	LDBPK_030190
LMI:	LMXM_03_0200
LBZ:	LBRM_03_0210
PTI:	PHATRDRAFT_31906
TPS:	THAPS_38066(ALD2)
PIF:	PITG_00034
RHD:	R2APBS1_0798
BCT:	GEM_4708
BGF:	BC1003_6034
BYI:	BYI23_C008480 BYI23_C011230
BPE:	BP0429
BPC:	BPTD_0444
BPER:	BN118_3444
VEI:	Veis_4685
MPT:	Mpe_A3747 Mpe_A3748
PPD:	Ppro_0074
DPS:	DP2491
DAT:	HRM2_16880(putA2)
ADE:	Adeh_0831
ACP:	A2cp1_0881
AFW:	Anae109_0887
ANK:	AnaeK_0877
MXA:	MXAN_5891(pruA)
MFU:	LILAB_14530 LILAB_16810
MSD:	MYSTI_01995 MYSTI_06503
CCX:	COCOR_06415(pruA)
SUR:	STAUR_1586(aldH) STAUR_6556(pruA)
SCL:	sce4459(rocA)
HOH:	Hoch_0264
SFU:	Sfum_2203
HMR:	Hipma_1679
TMO:	TMO_1578
BSU:	BSU03210(ycgN) BSU37780(rocA)
BSR:	I33_0366 I33_3927
BSL:	A7A1_0197 A7A1_1877
BSH:	BSU6051_03210(ycgN) BSU6051_37780(rocA)
BSY:	I653_01590 I653_18535
BSS:	BSUW23_01640(ycgN) BSUW23_18660(rocA)
BST:	GYO_4164(pruA)
BSO:	BSNT_00569(ycgN) BSNT_05780(rocA)
BSN:	BSn5_09885 BSn5_13185
BSQ:	B657_03210(putC) B657_37780(rocA)
BSUB:	BEST7613_0320(ycgN) BEST7613_6929(rocA)
BSX:	C663_0311(ycgN) C663_3684(rocA)
BLI:	BL01710(ycgN)
BLD:	BLi00374(ycgN)
BAO:	BAMF_0294(ycgN) BAMF_3612(rocA)
BAY:	RBAM_003450(ycgN) RBAM_034980(rocA)
BAQ:	BACAU_0288(rocA1) BACAU_3527(rocA3)
BYA:	BANAU_0287(rocA1) BANAU_3680(rocA3)
BAMP:	B938_01480 B938_17950
BAML:	BAM5036_0304(putC) BAM5036_3428(rocA)
BAZ:	BAMTA208_01475(ycgN) BAMTA208_19125(rocA)
BQL:	LL3_00302(ycgN) LL3_03923(rocA)
BXH:	BAXH7_00305(ycgN) BAXH7_03915(rocA)
BQY:	MUS_0304(ycgN) MUS_4158(rocA)
BAMI:	KSO_001570 KSO_017935
BAE:	BATR1942_02360 BATR1942_20245
BHA:	BH2737 BH3940
BAN:	BA_0309
BAR:	GBAA_0309
BAT:	BAS0295
BAH:	BAMEG_0366
BAI:	BAA_0363
BAX:	H9401_0285
BAL:	BACI_c03530(rocA)
BCE:	BC0344
BCA:	BCE_0338
BCZ:	BCZK0282(rocA)
BCR:	BCAH187_A0381
BCB:	BCB4264_A0355
BCU:	BCAH820_0340
BCG:	BCG9842_B4965
BCQ:	BCQ_0360(rocA)
BCX:	BCA_0382
BNC:	BCN_0305
BCF:	bcf_01770
BCER:	BCK_06365
BCY:	Bcer98_0289
BTK:	BT9727_0279(rocA)
BTL:	BALH_0301(rocA)
BTB:	BMB171_C0286
BTT:	HD73_0352
BTC:	CT43_CH0286
BTF:	YBT020_01580
BTM:	MC28_5024
BTG:	BTB_c03590(rocA)
BTI:	BTG_19395
BTN:	BTF1_27600
BTHT:	H175_ch0287
BWE:	BcerKBAB4_0290
BCL:	ABC0965
BPU:	BPUM_0301(ycgN)
BPF:	BpOF4_02610(rocA)
BMQ:	BMQ_0661(rocA) BMQ_3821(putC)
BMD:	BMD_0662(rocA) BMD_3813(putC)
BMH:	BMWSH_1401 BMWSH_4596(rocA)
BSE:	Bsel_0520
BCK:	BCO26_2004(rocA)
BAG:	Bcoa_2482
BJS:	MY9_0330 MY9_3870
BACI:	B1NLA3E_01640
OIH:	OB1349(rocA)
GKA:	GK0187 GK2889
GTN:	GTNG_0169
GTH:	Geoth_3631 Geoth_3969
GTE:	GTCCBUS3UF5_1940
GWC:	GWCH70_0274
GYC:	GYMC61_1043
GYA:	GYMC52_0165
GCT:	GC56T3_0164
GMC:	GY4MC1_3522
GGH:	GHH_c02150(rocA)
AFL:	Aflv_0249(rocA)
SAU:	SA2341(rocA)
SAV:	SAV2554(rocA)
SAW:	SAHV_2538(rocA)
SAH:	SaurJH1_2630
SAJ:	SaurJH9_2576
SAM:	MW2475(rocA)
SAS:	SAS2440
SAR:	SAR2634
SAC:	SACOL2569
SAX:	USA300HOU_2549
SAA:	SAUSA300_2491
SAO:	SAOUHSC_02869
SAE:	NWMN_2454
SAD:	SAAV_2620
SUU:	M013TW_2528
SUV:	SAVC_11650
SUH:	SAMSHR1132_23750
SUE:	SAOV_2599c
SUJ:	SAA6159_02450(rocA)
SUK:	SAA6008_02593(rocA)
SUC:	ECTR2_2407(pruA)
SUT:	SAT0131_02765(glnA)
SUQ:	HMPREF0772_10636(rocA)
SUZ:	MS7_2561(pruA)
SUD:	ST398NM01_2605
SUX:	SAEMRSA15_24570
SUW:	SATW20_26760
SUG:	SAPIG2605
SUF:	SARLGA251_23290
SAB:	SAB2428c
SUY:	SA2981_2491(rocA)
SAUB:	C248_2612
SAUM:	BN843_25910
SEP:	SE2116
SER:	SERP2128
SHA:	SH0500(rocA)
SSP:	SSP0311
SCA:	Sca_0564(rocA)
SLG:	SLGD_00435
SLN:	SLUG_04300
SSD:	SPSINT_0643
SDT:	SPSE_1879(pruA)
SWA:	A284_01700
LSP:	Bsph_0622
HHD:	HBHAL_1612(p5cdh1) HBHAL_4119(p5cdh2)
ESI:	Exig_2513
EAT:	EAT1b_0999
EAN:	Eab7_2357
MCL:	MCCL_0582
BBE:	BBR47_06890(rocA)
PJD:	Pjdr2_5338
GYM:	GYMC10_0427
PMS:	KNP414_07773(rocA)
PMQ:	PM3016_7292
PMW:	B2K_36805
AAC:	Aaci_0323
AAD:	TC41_0438
BTS:	Btus_0512 Btus_0835
SIV:	SSIL_0523
STH:	STH2741 STH646
DRM:	Dred_1731
DKU:	Desku_2682
DRU:	Desru_0540
DOR:	Desor_3981
DAI:	Desaci_1184
DMI:	Desmer_3089
OVA:	OBV_41000
TMR:	Tmar_2248
SAY:	TPY_0154
SAP:	Sulac_0143
TEP:	TepRe1_0046
TAE:	TEPIRE1_490
CPO:	COPRO5265_1373(pruA)
TNR:	Thena_0703
NTH:	Nther_1750
MTU:	Rv1187(rocA)
MTV:	RVBD_1187
MTC:	MT1224(pruA)
MRA:	MRA_1197(rocA)
MTF:	TBFG_11211
MTB:	TBMG_02795
MTK:	TBSG_02809
MTZ:	TBXG_002775
MTG:	MRGA327_07480
MTI:	MRGA423_07425
MTE:	CCDC5079_1098
MTL:	CCDC5180_1091
MTO:	MTCTRI2_1218(rocA)
MTD:	UDA_1187(rocA)
MTN:	ERDMAN_1329(rocA)
MTJ:	J112_06410
MTUB:	MT7199_1216(rocA)
MBO:	Mb1219(rocA)
MBB:	BCG_1249(rocA)
MBT:	JTY_1222(rocA)
MBM:	BCGMEX_1221(rocA)
MBK:	K60_012790
MAF:	MAF_12060(rocA)
MCE:	MCAN_11981(rocA)
MCQ:	BN44_11327(rocA)
MCV:	BN43_30255(rocA)
MCX:	BN42_21053(rocA)
MCZ:	BN45_30249(rocA)
MPA:	MAP2593c(rocA)
MAV:	MAV_1331(pruA)
MIT:	OCO_12390
MIR:	OCQ_12410
MIA:	OCU_12350
MID:	MIP_01978
MSM:	MSMEG_5119(pruA)
MSG:	MSMEI_4990(rocA)
MSA:	Mycsm_04902
MUL:	MUL_0932(rocA)
MVA:	Mvan_4526
MAB:	MAB_1330
MMV:	MYCMA_0701(rocA)
MMC:	Mmcs_4026
MKM:	Mkms_4101
MJL:	Mjls_4256
MMI:	MMAR_4253(rocA)
MRH:	MycrhN_3662
MMM:	W7S_06050
MCB:	Mycch_3930
MLI:	MULP_04432(rocA)
ASD:	AS9A_2786(rocA1)
NFA:	nfa47480
NCY:	NOCYR_4496(pruA)
NBR:	O3I_016510 O3I_035900
RHA:	RHA1_ro00348(rocA1) RHA1_ro05951(rocA2)
RER:	RER_47040
ROP:	ROP_29500 ROP_60130
REQ:	REQ_14220
GBR:	Gbro_1296
GPO:	GPOL_c38810
GOR:	KTR9_1219
SRT:	Srot_2794
SCO:	SCO5520(SC1C2.01)
SMA:	SAV_2723(rocA)
SGR:	SGR_1988
SCB:	SCAB_26991
SSX:	SACTE_4718
SVL:	Strvi_1882
SCT:	SCAT_4353
SCY:	SCATT_43400
SFA:	Sfla_1820
SBH:	SBI_03534
SHY:	SHJG_6617
SHO:	SHJGH_6377
SVE:	SVEN_5197
SDV:	BN159_2882(prnC)
SALB:	XNR_1311
STRP:	F750_5014
SFI:	SFUL_5376
KSK:	KSE_55740
KSE:	Ksed_08740
ICA:	Intca_1156 Intca_2486
MPH:	MLP_40810 MLP_50700
NCA:	Noca_0089 Noca_1220
KFL:	Kfla_1661
TFU:	Tfu_0433
NDA:	Ndas_0077
NAL:	B005_2867(pruA)
TCU:	Tcur_4016
SRO:	Sros_3096
FRA:	Francci3_2822
FRI:	FraEuI1c_4623
FAL:	FRAAL4347(putA)
FSY:	FsymDg_1118
ACE:	Acel_1750
NML:	Namu_0202
GOB:	Gobs_1425
BSD:	BLASA_1201
MMAR:	MODMU_1432
KRA:	Krad_4482
SEN:	SACE_1979
SVI:	Svir_30800
TBI:	Tbis_1510
AMD:	AMED_2661(putA)
AMN:	RAM_13525
AMM:	AMES_2633(putA)
PDX:	Psed_5167
AMI:	Amir_1082 Amir_3077
SESP:	BN6_12850 BN6_75890
STP:	Strop_0978
SAQ:	Sare_0915
MAU:	Micau_1020
MIL:	ML5_1267
VMA:	VAB18032_03305 VAB18032_09785
CAI:	Caci_0647 Caci_7579
SNA:	Snas_1861
RXY:	Rxyl_2922
CWO:	Cwoe_0535
ABA:	Acid345_0400
ACA:	ACP_2709(pruA)
ACM:	AciX9_1185
GMA:	AciX8_1535
TSA:	AciPR4_3365
TRS:	Terro_3390
SUS:	Acid_3538
BFR:	BF3796
PGI:	PG1269(pruA)
PGN:	PGN_1401
PGT:	PGTDC60_2208(pruA)
PDI:	BDI_2252
OSP:	Odosp_1952
TFO:	BFO_1363(pruA)
SRU:	SRU_1517(pruA)
SRM:	SRM_01717(pruA)
RMR:	Rmar_1231
RMG:	Rhom172_1275
CPI:	Cpin_5491
NKO:	Niako_1165
PHE:	Phep_0644
SHG:	Sph21_0351
SCN:	Solca_2978
HHY:	Halhy_4640
SGN:	SGRA_3525
CMR:	Cycma_1061
BBD:	Belba_0365
EVI:	Echvi_1300
CHU:	CHU_0703
DFE:	Dfer_3807
SLI:	Slin_5523
LBY:	Lbys_3137
RSI:	Runsl_1480
FLI:	Fleli_3547
EOL:	Emtol_2114
FAE:	FAES_0472
MTT:	Ftrac_3126
GFO:	GFO_0395
FJO:	Fjoh_1753
FPS:	FP0415(pruA)
FBR:	FBFL15_0558(pruA)
FCO:	FCOL_03025
FIN:	KQS_11860(pruA)
COC:	Coch_1569
CCM:	Ccan_07200
RBI:	RB2501_02650
ZPR:	ZPR_0943
CAT:	CA2559_12908
RAN:	Riean_0695
RAI:	RA0C_0932
RAR:	RIA_1551
RAG:	B739_1179
RAE:	G148_0923
FBC:	FB2170_16741
CAO:	Celal_2256
CLY:	Celly_0635
WVI:	Weevi_0733
KDI:	Krodi_0742
LAN:	Lacal_0515
ZGA:	zobellia_752(pruA)
MRS:	Murru_2053 Murru_2733
ASL:	Aeqsu_0509
ORH:	Ornrh_0358
PTQ:	P700755_002701
NDO:	DDD_1862
POM:	MED152_05970
FBA:	FIC_02392
SMG:	SMGWSS_249(putA)
SMS:	SMDSEM_260(putA)
SMH:	DMIN_02450
SUM:	SMCARI_270(putA)
FTE:	Fluta_2397
OHO:	Oweho_1581
GAU:	GAU_3073
TLI:	Tlie_1889
IAL:	IALB_1070
RRS:	RoseRS_1548
RCA:	Rcas_2305
CAU:	Caur_1794
CAG:	Cagg_3333
CHL:	Chy400_1941
HAU:	Haur_4731
STI:	Sthe_3501
ATM:	ANT_02040
CAP:	CLDAP_20900
DRA:	DR_0813 DR_A0030
DGE:	Dgeo_0850 Dgeo_1174
DDR:	Deide_13670 Deide_13850
DMR:	Deima_1366 Deima_1986
DPT:	Deipr_1835
DGO:	DGo_CA1424(rocA) DGo_CA2361
DPD:	Deipe_2789 Deipe_3650
TRA:	Trad_1881
TTH:	TTC1213
TTJ:	TTHA1578
TTS:	Ththe16_1596
TTL:	TtJL18_0467
TSC:	TSC_c22660
THC:	TCCBUS3UF1_4410
TOS:	Theos_1562
MRB:	Mrub_2639
MRE:	K649_09340
MSV:	Mesil_3126
OPR:	Ocepr_2044
MHD:	Marky_2140
TLE:	Tlet_1448
TME:	Tmel_0014
FNO:	Fnod_1641
FPE:	Ferpe_1995
PMO:	Pmob_0275
KOL:	Kole_1012
MPG:	Theba_2157
DDF:	DEFDS_1067
DAP:	Dacet_1509
CNI:	Calni_0885
FSI:	Flexsi_1434
TTR:	Tter_0870
HLA:	Hlac_3373
TAC:	Ta0603
TVO:	TVN0653
PTO:	PTO1261
APE:	APE_0807.1
SAI:	Saci_0166
SACN:	SacN8_00790
SACR:	SacRon12I_00790
SIS:	LS215_0436
SIA:	M1425_0398
SIM:	M1627_0412
SID:	M164_0436
SIY:	YG5714_0396
SIN:	YN1551_2635
SII:	LD85_0429
SIH:	SiH_0990
SIR:	SiRe_0401
SIC:	SiL_0430
MSE:	Msed_0367
MCN:	Mcup_1708
TUZ:	TUZN_1132
TTN:	TTX_1787(putA)
ASC:	ASAC_0743
NIR:	NSED_08130
NGA:	Ngar_c32570(rocA)
HAH:	Halar_1051

» show all

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Ontology (5)   
   KEGG BRITE (3)   
   GO (1)   
   COG (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (11)   
   KEGG ENZYME (1)   
   KEGG REACTION (6)   
   KEGG RCLASS (4)   
Gene (3325)   
   KEGG GENES (678)   
   KEGG DGENES (20)   
   KEGG EGENES (209)   
   KEGG MGENES (2418)   
Protein sequence (598)   
   UniProt (598)   
All databases (3946)   

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