KEGG   ORTHOLOGY: K00408Help
Entry
K00408                      KO                                     

Name
WNT4
Definition
wingless-type MMTV integration site family, member 4
Pathway
mTOR signaling pathway
Wnt signaling pathway
Axon guidance
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Thyroid hormone signaling pathway
HTLV-I infection
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
Module
M00677  
Wnt signaling
Disease
H00598  
46,XX disorders of sex development (Disorders of gonadal development)
H00600  
46,XX disorders of sex development (Other)
H00607  
46,XY disorders of sex development (Disorders of gonadal development)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   04390 Hippo signaling pathway
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   04150 mTOR signaling pathway
    K00408  WNT4; wingless-type MMTV integration site family, member 4
 Cellular Processes
  Cellular community
   04550 Signaling pathways regulating pluripotency of stem cells
    K00408  WNT4; wingless-type MMTV integration site family, member 4
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   04916 Melanogenesis
    K00408  WNT4; wingless-type MMTV integration site family, member 4
  Development
   04360 Axon guidance
    K00408  WNT4; wingless-type MMTV integration site family, member 4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   05205 Proteoglycans in cancer
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   05217 Basal cell carcinoma
    K00408  WNT4; wingless-type MMTV integration site family, member 4
  Infectious diseases
   05166 HTLV-I infection
    K00408  WNT4; wingless-type MMTV integration site family, member 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K00408  WNT4; wingless-type MMTV integration site family, member 4
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Morphogens
   K00408  WNT4; wingless-type MMTV integration site family, member 4
BRITE hierarchy
Genes
HSA: 
54361(WNT4)
PTR: 
469212(WNT4)
PPS: 
100992168(WNT4)
GGO: 
101139722(WNT4)
PON: 
100436330(WNT4)
NLE: 
100604353(WNT4)
MCC: 
707864(WNT4)
MCF: 
102143058(WNT4)
CSAB: 
103225420(WNT4)
RRO: 
104663222(WNT4)
CJC: 
100387135(WNT4)
SBQ: 
101050255(WNT4)
MMU: 
22417(Wnt4)
RNO: 
84426(Wnt4)
CGE: 
100769003(Wnt4)
NGI: 
103746395(Wnt4)
HGL: 
101701972(Wnt4)
OCU: 
100303773(WNT4)
TUP: 
102493340(WNT4)
CFA: 
612367(WNT4)
AML: 
100468584(WNT4)
UMR: 
103666795(WNT4)
FCA: 
101095185(WNT4)
BTA: 
789600(WNT4)
BOM: 
102269858(WNT4)
PHD: 
102334111(WNT4)
CHX: 
102187819(WNT4)
OAS: 
101122423(WNT4)
SSC: 
100327037(WNT4)
CFR: 
102522577(WNT4)
BACU: 
103009300(WNT4)
LVE: 
103087836(WNT4)
ECB: 
100071678(WNT4)
MYB: 
102240589(WNT4)
MYD: 
102756007(WNT4)
PALE: 
102888866(WNT4)
LAV: 
100664388(WNT4)
MDO: 
100026048(WNT4)
SHR: 
100925510(WNT4)
OAA: 
100075238(WNT4)
GGA: 
395561(WNT4)
MGP: 
100547391(WNT4)
CJO: 
107323388(WNT4)
APLA: 
TGU: 
100230804(WNT4)
GFR: 
FAB: 
101806519(WNT4)
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
102450128(WNT4) 102455801(WNT4)
CMY: 
ACS: 
100567689(wnt4)
PBI: 
103054356(WNT4)
GJA: 
XLA: 
397706(wnt4)
XTR: 
100491282(wnt4)
DRE: 
30123(wnt4a)
TRU: 
TNG: 
MZE: 
OLA: 
100301590(wnt4) 100301591(wnt4b)
XMA: 
SASA: 
LCM: 
CMK: 
103181434(wnt4)
BFO: 
SPU: 
SKO: 
100329013(Wnt4)
DPX: 
ISC: 
CEL: 
CBR: 
CBG11282(Cbr-mom-2)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Bernardi H, Gay S, Fedon Y, Vernus B, Bonnieu A, Bacou F
  Title
Wnt4 activates the canonical beta-catenin pathway and regulates negatively myostatin: functional implication in myogenesis.
  Journal
Am J Physiol Cell Physiol 300:C1122-38 (2011)
Reference
  Authors
Saulnier DM, Ghanbari H, Brandli AW
  Title
Essential function of Wnt-4 for tubulogenesis in the Xenopus pronephric kidney.
  Journal
Dev Biol 248:13-28 (2002)
  Sequence
[xla:397706]
Reference
  Authors
Jordan BK, Mohammed M, Ching ST, Delot E, Chen XN, Dewing P, Swain A, Rao PN, Elejalde BR, Vilain E
  Title
Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.
  Journal
Am J Hum Genet 68:1102-9 (2001)
  Sequence
[hsa:54361]

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