KEGG   ORTHOLOGY: K00488Help
Entry
K00488                      KO                                     

Name
CYP27A
Definition
cholestanetriol 26-monooxygenase [EC:1.14.13.15]
Pathway
Primary bile acid biosynthesis
PPAR signaling pathway
Module
M00104  
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Disease
H00151  
Cerebrotendinous xanthomatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00488  CYP27A; cholestanetriol 26-monooxygenase
 Organismal Systems
  Endocrine system
   03320 PPAR signaling pathway
    K00488  CYP27A; cholestanetriol 26-monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00104  Bile acid biosynthesis, cholesterol => cholate
     K00488  CYP27A; cholestanetriol 26-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.15  cholestanetriol 26-monooxygenase
     K00488  CYP27A; cholestanetriol 26-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP27 family
   K00488  CYP27A; cholestanetriol 26-monooxygenase
BRITE hierarchy
Other DBs
Genes
HSA: 
1593(CYP27A1)
PTR: 
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
700192(CYP27A1)
MCF: 
CJC: 
100393783(CYP27A1)
MMU: 
104086(Cyp27a1)
RNO: 
301517(Cyp27a1)
CGE: 
HGL: 
TUP: 
CFA: 
610489(CYP27A1)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
511960(CYP27A1)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
100126282(CYP27A1)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
100011045(CYP27A1)
SHR: 
OAA: 
GGA: 
431683(CYP27A1)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
CMY: 
ACS: 
PBI: 
XLA: 
446987(cyp27a1)
XTR: 
DRE: 
322341(cyp27a1.4) 565876 795106(cyp27a1.2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
HRO: 
AQU: 
EHX: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Pikuleva IA, Puchkaev A, Bjorkhem I
  Title
Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1.
  Journal
Biochemistry 40:7621-9 (2001)
  Sequence
[hsa:1593]

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