KEGG   ORTHOLOGY: K00488Help
Entry
K00488                      KO                                     

Name
CYP27A
Definition
cholestanetriol 26-monooxygenase [EC:1.14.15.15]
Pathway
Primary bile acid biosynthesis
PPAR signaling pathway
Module
M00104  
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Disease
H00151  
Cerebrotendinous xanthomatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00488  CYP27A; cholestanetriol 26-monooxygenase
 Organismal Systems
  Endocrine system
   03320 PPAR signaling pathway
    K00488  CYP27A; cholestanetriol 26-monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00104  Bile acid biosynthesis, cholesterol => cholate
     K00488  CYP27A; cholestanetriol 26-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.15  cholestanetriol 26-monooxygenase
     K00488  CYP27A; cholestanetriol 26-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP27 family
   K00488  CYP27A; cholestanetriol 26-monooxygenase
BRITE hierarchy
Other DBs
Genes
HSA: 
1593(CYP27A1)
PTR: 
459951(CYP27A1)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
700192(CYP27A1)
MCF: 
102129822(CYP27A1)
CSAB: 
RRO: 
CJC: 
100393783(CYP27A1)
SBQ: 
MMU: 
104086(Cyp27a1)
RNO: 
301517(Cyp27a1)
CGE: 
NGI: 
HGL: 
OCU: 
100348736(CYP27A1)
TUP: 
CFA: 
610489(CYP27A1)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
511960(CYP27A1)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
100126282(CYP27A1)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
LAV: 
MDO: 
100011045(CYP27A1)
SHR: 
OAA: 
GGA: 
431683(CYP27A1)
MGP: 
CJO: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
CMY: 
ACS: 
PBI: 
GJA: 
XLA: 
446987(cyp27a1)
XTR: 
DRE: 
322341(cyp27a1.4) 565876 795106(cyp27a1.2)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
BFO: 
HRO: 
ADF: 
AQU: 
SPAR: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1708392
  Authors
Cali JJ, Russell DW
  Title
Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
  Journal
J Biol Chem 266:7774-8 (1991)
  Sequence
[hsa:1593]

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