KEGG   ORTHOLOGY: K00488Help
Entry
K00488                      KO                                     

Name
CYP27A1
Definition
cholestanetriol 26-monooxygenase [EC:1.14.15.15]
Pathway
ko00120  Primary bile acid biosynthesis
ko01100  Metabolic pathways
ko03320  PPAR signaling pathway
ko04979  Cholesterol metabolism
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Disease
H00151  Cerebrotendinous xanthomatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
 Organismal Systems
  Endocrine system
   03320 PPAR signaling pathway
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
  Digestive system
   04979 Cholesterol metabolism
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00104  Bile acid biosynthesis, cholesterol => cholate
     K00488  CYP27A1; cholestanetriol 26-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.15  cholestanetriol 26-monooxygenase
     K00488  CYP27A1; cholestanetriol 26-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP27 family
   K00488  CYP27A1; cholestanetriol 26-monooxygenase
BRITE hierarchy
Other DBs
RN: R04806 R04807 R08505 R08758 R08759 R08760 R08761 R11142
GO: 0047749
Genes
HSA: 1593(CYP27A1)
PTR: 459951
PPS: 100989602
GGO: 101131774
PON: 100451841
NLE: 100606147
MCC: 700192(CYP27A1)
MCF: 102129822(CYP27A1)
CSAB: 103217882(CYP27A1)
RRO: 104660034
RBB: 108518476
CJC: 100393783(CYP27A1)
SBQ: 101029011
MMU: 104086(Cyp27a1)
RNO: 301517(Cyp27a1)
CGE: 100751584
NGI: 103727727
HGL: 101700018
CCAN: 109679372
OCU: 100348736(CYP27A1)
TUP: 102471009
CFA: 610489(CYP27A1)
AML: 100480153
UMR: 103662754
ORO: 101374314
FCA: 101091962
PTG: 102958835
AJU: 106970103
BTA: 511960(CYP27A1)
BOM: 102275770
BIU: 109570716
PHD: 102319907
CHX: 102177672
OAS: 101111528
SSC: 100126282(CYP27A1)
CFR: 102517717
CDK: 105096090
BACU: 102999025
LVE: 103080163
OOR: 101288855
ECB: 100055936(CYP27A1)
EPZ: 103567914
EAI: 106838458
MYB: 102255768
MYD: 102761397
HAI: 109380589
RSS: 109452673
PALE: 102883032
LAV: 100662261
TMU: 101347420
MDO: 100011045(CYP27A1)
SHR: 100918281
OAA: 100093207
GGA: 431683(CYP27A1)
MGP: 100539204
CJO: 107317020
APLA: 101802865
ACYG: 106039314
TGU: 100232323
GFR: 102036968
FAB: 101815213
PHI: 102102670
PMAJ: 107207520
CCW: 104693966
FPG: 101912381
FCH: 102046779
CLV: 102085729
EGZ: 104132432
ASN: 102377709
CMY: 102937044
CPIC: 101943409
ACS: 100565025
PVT: 110078231
PBI: 103054208
XLA: 100381137(cyp27a1) 108702937 446987(LOC100145331.L) 733412
XTR: 100145331(cyp27a1) 100145773(cyp27a1) 100496109 594905(cyp27b1)
DRE: 322341(cyp27a1.4) 565876(si:dkey-91i10.3) 795106(cyp27a1.2)
CMK: 103189020
ADF: 107358539
SPAR: SPRG_05921
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1708392
  Authors
Cali JJ, Russell DW
  Title
Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
  Journal
J Biol Chem 266:7774-8 (1991)
  Sequence
[hsa:1593]

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