KEGG   ORTHOLOGY: K00497Help
Entry
K00497                      KO                                     
Name
CYP11B1
Definition
cytochrome P450, family 11, subfamily B1 (steroid 11beta-monooxygenase) [EC:1.14.15.4]
Pathway
Steroid hormone biosynthesis
Module
M00108  
C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109  
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Disease
H00216  
Congenital adrenal hyperplasia (CAH)
H00599  
46,XX disorders of sex development (Disorders related to androgen excess)
H00602  
Glucocorticoid-remediable aldosteronism (GRA)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00497  CYP11B1; cytochrome P450, family 11, subfamily B1 (steroid 11beta-monooxygenase)
KEGG pathway modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
     K00497  CYP11B1; cytochrome P450, family 11, subfamily B1 (steroid 11beta-monooxygenase)
    M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
     K00497  CYP11B1; cytochrome P450, family 11, subfamily B1 (steroid 11beta-monooxygenase)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     K00497  CYP11B1; cytochrome P450, family 11, subfamily B1 (steroid 11beta-monooxygenase)
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP11 family
   CYP11B subfamily
    K00497  CYP11B1; cytochrome P450, family 11, subfamily B1 (steroid 11beta-monooxygenase)
BRITE hierarchy
Other DBs
Genes
HSA: 
1584(CYP11B1)
PTR: 
PPS: 
GGO: 
PON: 
MCC: 
695793(CYP11B1)
MMU: 
13072(Cyp11b2)
RNO: 
24294(Cyp11b2) 353498(Cyp11b3)
CFA: 
482071(CYP11B2)
AML: 
FCA: 
101097790
BTA: 
282422(CYP11B1)
ECB: 
100063645
MDO: 
100032885
SHR: 
100930767
OAA: 
100082065
ACS: 
100560890
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3485096
  Authors
Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P
  Title
The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.
  Journal
J Biol Chem 261:3556-62 (1986)
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