KEGG   ORTHOLOGY: K00501Help
Entry
K00501                      KO                                     

Name
TH
Definition
tyrosine 3-monooxygenase [EC:1.14.16.2]
Pathway
Tyrosine metabolism
Isoquinoline alkaloid biosynthesis
Dopaminergic synapse
Prolactin signaling pathway
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
Module
M00042  
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Disease
H00831  
Primary dystonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00350 Tyrosine metabolism
    K00501  TH; tyrosine 3-monooxygenase
  Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
 Organismal Systems
  Endocrine system
   04917 Prolactin signaling pathway
    K00501  TH; tyrosine 3-monooxygenase
  Nervous system
   04728 Dopaminergic synapse
    K00501  TH; tyrosine 3-monooxygenase
 Human Diseases
  Neurodegenerative diseases
   05012 Parkinson's disease
    K00501  TH; tyrosine 3-monooxygenase
  Substance dependence
   05030 Cocaine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05031 Amphetamine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05034 Alcoholism
    K00501  TH; tyrosine 3-monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Aromatic amino acid metabolism
    M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
     K00501  TH; tyrosine 3-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     K00501  TH; tyrosine 3-monooxygenase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
7054(TH)
PTR: 
450955(TH)
PPS: 
GGO: 
PON: 
MCC: 
721137(TH)
MCF: 
MMU: 
21823(Th)
RNO: 
25085(Th)
CGE: 
HGL: 
TUP: 
CFA: 
403444(TH)
AML: 
FCA: 
PTG: 
BTA: 
280707(TH)
BOM: 
PHD: 
CHX: 
OAS: 
CFR: 
BACU: 
LVE: 
ECB: 
MYD: 
PALE: 
MDO: 
OAA: 
GGA: 
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
XTR: 
DRE: 
30384(th)
TRU: 
101078018(th) 446095(2nd_copy)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
493867(th)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
CQU: 
AME: 
408930(TyHyd)
NVI: 
TCA: 
654918(Th)
BMOR: 
API: 
PHU: 
CBR: 
CBG07026(Cbr-cat-2)
BMY: 
LOA: 
TSP: 
SMM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Daubner SC, Le T, Wang S
  Title
Tyrosine hydroxylase and regulation of dopamine synthesis.
  Journal
Arch Biochem Biophys 508:1-12 (2011)

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