KEGG   ORTHOLOGY: K00512Help
Entry
K00512                      KO                                     

Name
CYP17A
Definition
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Pathway
Steroid hormone biosynthesis
Ovarian steroidogenesis
Prolactin signaling pathway
Module
M00109  
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
M00110  
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Disease
H00216  
Congenital adrenal hyperplasia (CAH)
H00608  
46,XY disorders of sex development (Disorders in androgen synthesis or action)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04917 Prolactin signaling pathway
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
    M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP17 family
   K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
BRITE hierarchy
Other DBs
Genes
HSA: 
1586(CYP17A1)
PTR: 
450141(CYP17A1)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
678693(CYP17A1)
MCF: 
102133235(CYP17)
CSAB: 
103216445(CYP17A1)
RRO: 
CJC: 
100400572(CYP17A1)
SBQ: 
MMU: 
13074(Cyp17a1)
RNO: 
25146(Cyp17a1)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
477807(CYP17A1)
AML: 
UMR: 
FCA: 
493967(CYP17A1)
PTG: 
AJU: 
BTA: 
281739(CYP17A1)
BOM: 
PHD: 
CHX: 
OAS: 
105601846(CYP17) 493968(CYP17A1)
SSC: 
403330(CYP17A1)
CFR: 
BACU: 
LVE: 
ECB: 
100034232(CYP17A1)
MYB: 
MYD: 
HAI: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
425056(CYP17A1)
MGP: 
CJO: 
107316091(P-450c17)
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
102567971(CYP17A1)
PSS: 
CMY: 
CPIC: 
ACS: 
PBI: 
GJA: 
XLA: 
100036774(cyp17a1.L)
XTR: 
DRE: 
399692(cyp17a1)
IPU: 
TRU: 
100125766(cyp17a2) 100125798(cyp17a1)
TNG: 
LCO: 
104935158(CYP17I) 104936651(CYP17II)
MZE: 
OLA: 
100125816(cyp17) 101170547(cyp17a2)
XMA: 
SASA: 
LCM: 
CMK: 
BFO: 
SKO: 
ISC: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
MTR: 
ADU: 
AIP: 
LJA: 
Lj0g3v0006169.1(Lj0g3v0006169.1) Lj0g3v0355859.1(Lj0g3v0355859.1) Lj0g3v0356929.1(Lj0g3v0356929.1) Lj1g3v4303210.1(Lj1g3v4303210.1) Lj6g3v0777300.1(Lj6g3v0777300.1)
LANG: 
MDM: 
PXB: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SOT: 
INI: 
DOSA: 
Os04t0101400-01(Os04g0101400) Os05t0515200-01(Os05g0515200) Os12t0640200-00(Os12g0640200)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_01g012045(SORBIDRAFT_01g012045) SORBI_03g001010(SORBIDRAFT_03g001010) SORBI_04g000730(SORBIDRAFT_04g000730) SORBI_04g008860(SORBIDRAFT_04g008860) SORBI_05g018890(SORBIDRAFT_05g018890) SORBI_05g027010(SORBIDRAFT_05g027010) SORBI_06g002120(SORBIDRAFT_06g002120) SORBI_06g011070(SORBIDRAFT_06g011070) SORBI_06g021610(SORBIDRAFT_06g021610) SORBI_07g000530(SORBIDRAFT_07g000530) SORBI_07g008870(SORBIDRAFT_07g008870)
ZMA: 
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
FCY: 
AG: 
AAF65823(CYP17A1) AAG02227(CYP17A1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3025870
  Authors
Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE, Miller WL
  Title
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
  Journal
Proc Natl Acad Sci U S A 84:407-11 (1987)
DOI:10.1073/pnas.84.2.407
  Sequence
[hsa:1586]
Reference
PMID:6966286
  Authors
Yoshida KI, Oshima H, Troen P
  Title
Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17 alpha-hydroxylation.
  Journal
J Clin Endocrinol Metab 50:895-9 (1980)
DOI:10.1210/jcem-50-5-895

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