KEGG ORTHOLOGY: K00513

ORTHOLOGY: K00513

Entry

K00513                      KO

Symbol

CYP21A

Name

steroid 21-monooxygenase [EC:1.14.14.16]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

Module

M00108

C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Reaction

R02213

progesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)

R02838

21-deoxycortisol,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)

R03326

17alpha-hydroxyprogesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)

R03784

pregnenolone,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)

R03849

11beta-hydroxyprogesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)

R04675

17alpha-hydroxypregnenolone,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)

Disease

H00216

Congenital adrenal hyperplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00513  CYP21A; steroid 21-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    K00513  CYP21A; steroid 21-monooxygenase
   04927 Cortisol synthesis and secretion
    K00513  CYP21A; steroid 21-monooxygenase
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00513  CYP21A; steroid 21-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00513  CYP21A; steroid 21-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     K00513  CYP21A; steroid 21-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP21 family
   K00513  CYP21A; steroid 21-monooxygenase

Other DBs

GO:

0004509

Genes

HSA:	1589(CYP21A2)

PTR:	107973061 745345

PPS:	117980568 117980569

GGO:	101147473 109023079

PON:	100461354 112131288

NLE:

100579180

HMH:

116460301

MCC:	717020(CYP21A2)

MCF:	102130610(CYP21A2)

MTHB:

126953219

MNI:

105497657

CSAB:

103221724(CYP21A2)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100395918(CYP21A2)

SBQ:

101047673

CIMI:

108299804(CYP21A2)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13079(Cyp21a1)

MCAL:

110312588

MPAH:

110335614

RNO:	24298(Cyp21a1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100342636 127488899

OPI:

101536144

TUP:

102491327

GVR:

103592340

CFA:	415124(CYP21A2)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101094596(CYP21A2)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	281741(CYP21A2)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:	105612707 114108679

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	403337(CYP21A2)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:

EPZ:

EAI:

MYB:

MMYO:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

OAA:

GGA:	429828(CYP21A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

SVG:

MMEA:

HRT:

EGZ:

ACHC:

AGEN:

SHAB:

RTD:

DNE:

ASN:

AMJ:	102575314(CYP21A2)

CCAY:

DCC:

CPIC:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

PGUT:

APRI:

PTEX:

VKO:

PMUA:

PRAF:

HCG:

GJA:

STOW:

EMC:

XLA:	447267(cyp21a2.1.L)

XTR:	100489813(cyp21a2.1)

NPR:

RTEM:

BBUF:

BGAR:

MUO:	115459441 115466193

GSH:

117346866

DRE:	793249(cyp21a2)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

STRU:

OTW:	112225325 112243760

OMY:	110520728 110535199

OGO:	124022774 124022776

OKI:	109900152 116365614

OKE:

SALP:

SNH:

CCLU:

ELS:

SFM:

PKI:

AANG:

PSPA:

ARUT:

LCM:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:	133341661 133354699

» show all

Reference

PMID:3038528 (CYP21A2)

Authors

Rodrigues NR, Dunham I, Yu CY, Carroll MC, Porter RR, Campbell RD

Title

Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia.

Journal

EMBO J 6:1653-61 (1987)
DOI:10.1002/j.1460-2075.1987.tb02414.x

Sequence

[hsa:1589]

Reference

PMID:15860270

Authors

Luu-The V, Pelletier G, Labrie F

Title

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

Journal

J Steroid Biochem Mol Biol 93:269-76 (2005)
DOI:10.1016/j.jsbmb.2005.01.003

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