Entry |
|
Name |
|
Definition |
|
Pathway |
| Steroid hormone biosynthesis | | Metabolic pathways | | Aldosterone synthesis and secretion | | Cortisol synthesis and secretion | | Cushing's syndrome |
|
Module |
| C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone | | C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone |
|
Disease |
| Congenital adrenal hyperplasia (CAH) | | 46,XX disorders of sex development (Disorders related to androgen excess) |
|
Brite |
KEGG Orthology (KO) [BR:ko00001]
Metabolism
Lipid metabolism
00140 Steroid hormone biosynthesis
K00513 CYP21A; steroid 21-monooxygenase
Organismal Systems
Endocrine system
04925 Aldosterone synthesis and secretion
K00513 CYP21A; steroid 21-monooxygenase
04927 Cortisol synthesis and secretion
K00513 CYP21A; steroid 21-monooxygenase
Human Diseases
Endocrine and metabolic diseases
04934 Cushing's syndrome
K00513 CYP21A; steroid 21-monooxygenase
KEGG modules [BR:ko00002]
Pathway module
Carbohydrate and lipid metabolism
Sterol biosynthesis
M00108 C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
K00513 CYP21A; steroid 21-monooxygenase
M00109 C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
K00513 CYP21A; steroid 21-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.16 steroid 21-monooxygenase
K00513 CYP21A; steroid 21-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
CYP21 family
K00513 CYP21A; steroid 21-monooxygenase
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Other DBs |
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Genes |
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   |
Reference |
|
Authors |
Rodrigues NR, Dunham I, Yu CY, Carroll MC, Porter RR, Campbell RD |
Title |
Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia. |
Journal |
EMBO J 6:1653-61 (1987) |
Sequence |
|
Reference |
|
Authors |
Luu-The V, Pelletier G, Labrie F |
Title |
Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase. |
Journal |
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