KEGG   ORTHOLOGY: K00513Help
Entry
K00513                      KO                                     

Name
CYP21A
Definition
steroid 21-monooxygenase [EC:1.14.14.16]
Pathway
Steroid hormone biosynthesis
Aldosterone synthesis and secretion
Module
M00108  
C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109  
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Disease
H00216  
Congenital adrenal hyperplasia (CAH)
H00599  
46,XX disorders of sex development (Disorders related to androgen excess)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00513  CYP21A; steroid 21-monooxygenase
 Organismal Systems
  Endocrine system
   04925 Aldosterone synthesis and secretion
    K00513  CYP21A; steroid 21-monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
     K00513  CYP21A; steroid 21-monooxygenase
    M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
     K00513  CYP21A; steroid 21-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     K00513  CYP21A; steroid 21-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP21 family
   K00513  CYP21A; steroid 21-monooxygenase
BRITE hierarchy
Other DBs
Genes
HSA: 
1589(CYP21A2)
PTR: 
471972(CYP21A2) 745345
GGO: 
PON: 
NLE: 
MCC: 
717020(CYP21A2)
MCF: 
CSAB: 
103221724(CYP21A2)
RRO: 
CJC: 
100395918(CYP21A2)
SBQ: 
101047673
MMU: 
13079(Cyp21a1)
RNO: 
24298(Cyp21a1)
CGE: 
100767691
NGI: 
103724459
HGL: 
101717066
CCAN: 
109689568
OCU: 
100342636
TUP: 
102491327
CFA: 
415124(CYP21A2)
AML: 
100478117
UMR: 
103682334
FCA: 
101094596(21-OHase)
PTG: 
102966729
AJU: 
106983476
BTA: 
107131127 281741(CYP21) 282425(CYP21A2)
BOM: 
102267885
BIU: 
109576856
CHX: 
102174710
OAS: 
105612707(P-450-c21)
SSC: 
403337(CYP21A2)
CFR: 
102506530
BACU: 
103003841
LVE: 
103069558
ECB: 
100059277
MYB: 
102254156
MYD: 
102775283
HAI: 
109373090
RSS: 
109436782
PALE: 
102898380
LAV: 
100658069
MDO: 
100025565
SHR: 
100932451
OAA: 
100086194
GGA: 
429828(CYP21A1)
MGP: 
100538455
CJO: 
107321560
APLA: 
101794100
TGU: 
100226057
GFR: 
102042267
FAB: 
101816789
PHI: 
102108296
CCW: 
104683162
AMJ: 
102575314(CYP21A2)
CPIC: 
101950331
ACS: 
100552382
PBI: 
103054275
GJA: 
107107307
XLA: 
447267(cyp21a2.1.L)
XTR: 
100489813(cyp21a2.1)
DRE: 
793249(cyp21a2)
IPU: 
108261472
TRU: 
101065814(cyp21A2)
TNG: 
GSTEN00034163G001
LCO: 
104922752 109137350
MZE: 
101472385
OLA: 
101157155
XMA: 
102218645
CSEM: 
103388483
SASA: 
106606086
LCM: 
102346130
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3038528
  Authors
Rodrigues NR, Dunham I, Yu CY, Carroll MC, Porter RR, Campbell RD
  Title
Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia.
  Journal
EMBO J 6:1653-61 (1987)
  Sequence
[hsa:1589]
Reference
  Authors
Luu-The V, Pelletier G, Labrie F
  Title
Quantitative appreciation of steroidogenic gene expression in mouse tissues: new  roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.
  Journal
J Steroid Biochem Mol Biol 93:269-76 (2005)
DOI:10.1016/j.jsbmb.2005.01.003
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