KEGG ORTHOLOGY: K00513

ORTHOLOGY: K00513

Entry

K00513 KO

Name

CYP21A

Definition

steroid 21-monooxygenase [EC:1.14.99.10]

Pathway

ko00140

Steroid hormone biosynthesis

Module

M00108	C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109	C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Disease

H00216	Congenital adrenal hyperplasia (CAH)
H00599	46,XX disorders of sex development (Disorders related to androgen excess)

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00513  CYP21A; steroid 21-monooxygenase
KEGG modules [BR:ko00002]
Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
     K00513  CYP21A; steroid 21-monooxygenase
    M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
     K00513  CYP21A; steroid 21-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.10  steroid 21-monooxygenase
     K00513  CYP21A; steroid 21-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP21 family
   K00513  CYP21A; steroid 21-monooxygenase

Other DBs

RN:

R02213 R02838 R03326 R03784 R03849 R04675

GO:

0004509

Genes

HSA:	1589(CYP21A2)
PTR:	471972(CYP21A2) 745345
GGO:	101147473
PON:	100461354
MCC:	717020(CYP21A2)
MCF:	102130610
MMU:	13079(Cyp21a1)
RNO:	24298(Cyp21a1)
CGE:	100767691
HGL:	101717066
TUP:	102491327
CFA:	415124(CYP21A2)
FCA:	101094596(21-OHase)
PTG:	102966729
BTA:	281741(CYP21) 282425(CYP21A2)
BOM:	102267885
CHX:	102174710
SSC:	403337(CYP21A2)
CFR:	102506530
ECB:	100059277
MYB:	102254156
MYD:	102775283
PALE:	102898380
MDO:	100025565
SHR:	100932451
OAA:	100086194
GGA:	429828(CYP21A2)
MGP:	100538455
FAB:	101816789
PHI:	102108296
APLA:	101794100
ASN:	102384240
ACS:	100552382
XLA:	447267(cyp21a2.1)
XTR:	100489813
DRE:	793249
TRU:	101065814
MZE:	101472385
OLA:	101157155(cyp21a2)
XMA:	102218645
LCM:	102346130

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Ontology (6)   
   KEGG BRITE (5)   
   GO (1)   
Pathway (45)   
   KEGG PATHWAY (4)   
   KEGG MODULE (41)   
Disease (2)   
   KEGG DISEASE (2)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (6)   
   KEGG RCLASS (1)   
Gene (55)   
   KEGG GENES (43)   
   KEGG DGENES (2)   
   EGENES (6)   
   OC (4)   
Protein sequence (24)   
   UniProt (19)   
   SWISS-PROT (5)   
All databases (140)   

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