KEGG   ORTHOLOGY: K00513Help
Entry
K00513                      KO                                     

Name
CYP21A
Definition
steroid 21-monooxygenase [EC:1.14.14.16]
Pathway
Steroid hormone biosynthesis
Aldosterone synthesis and secretion
Module
M00108  
C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109  
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Disease
H00216  
Congenital adrenal hyperplasia (CAH)
H00599  
46,XX disorders of sex development (Disorders related to androgen excess)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00513  CYP21A; steroid 21-monooxygenase
 Organismal Systems
  Endocrine system
   04925 Aldosterone synthesis and secretion
    K00513  CYP21A; steroid 21-monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
     K00513  CYP21A; steroid 21-monooxygenase
    M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
     K00513  CYP21A; steroid 21-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     K00513  CYP21A; steroid 21-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP21 family
   K00513  CYP21A; steroid 21-monooxygenase
BRITE hierarchy
Other DBs
Genes
HSA: 
1589(CYP21A2)
PTR: 
471972(CYP21A2) 745345
GGO: 
PON: 
NLE: 
MCC: 
717020(CYP21A2)
MCF: 
RRO: 
CJC: 
100395918(CYP21A2)
MMU: 
13079(Cyp21a1)
RNO: 
24298(Cyp21a1)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
415124(CYP21A2)
AML: 
UMR: 
FCA: 
101094596(21-OHase)
PTG: 
BTA: 
281741(CYP21) 282425(CYP21A2)
BOM: 
CHX: 
OAS: 
105612707(P-450-c21)
SSC: 
403337(CYP21A2)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
429828(CYP21A2)
MGP: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
AMJ: 
102575314(CYP21A2)
ACS: 
PBI: 
XLA: 
447267(cyp21a2.1)
XTR: 
100489813(cyp21a2.1)
DRE: 
793249(cyp21a2)
TRU: 
101065814(cyp21A2)
MZE: 
OLA: 
101157155(cyp21a2)
XMA: 
LCM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Luu-The V, Pelletier G, Labrie F
  Title
Quantitative appreciation of steroidogenic gene expression in mouse tissues: new  roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.
  Journal
J Steroid Biochem Mol Biol 93:269-76 (2005)

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