KEGG   ORTHOLOGY: K00907Help
Entry
K00907                      KO                                     

Name
MYLK
Definition
myosin-light-chain kinase [EC:2.7.11.18]
Pathway
Calcium signaling pathway
Vascular smooth muscle contraction
Focal adhesion
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Gastric acid secretion
Disease
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    K00907  MYLK; myosin-light-chain kinase
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K00907  MYLK; myosin-light-chain kinase
  Cell communication
   04510 Focal adhesion
    K00907  MYLK; myosin-light-chain kinase
 Organismal Systems
  Endocrine system
   04921 Oxytocin signaling pathway
    K00907  MYLK; myosin-light-chain kinase
  Circulatory system
   04270 Vascular smooth muscle contraction
    K00907  MYLK; myosin-light-chain kinase
  Digestive system
   04971 Gastric acid secretion
    K00907  MYLK; myosin-light-chain kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.18  myosin-light-chain kinase
     K00907  MYLK; myosin-light-chain kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: CAMK group
  MLCK family
   K00907  MYLK; myosin-light-chain kinase
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
340156(MYLK4) 4638(MYLK) 85366(MYLK2) 91807(MYLK3)
PTR: 
101057233(MYLK) 460640(MYLK) 465143(MYLK3) 471840(MYLK4) 742591(MYLK2)
PPS: 
100974667(MYLK3) 100978891(MYLK2) 100979422(MYLK) 100995666(MYLK4)
GGO: 
101142619(MYLK3) 101143745(MYLK2) 101151517(MYLK) 101151667(MYLK4)
PON: 
100171951(MYLK3) 100444714(MYLK4) 100452913(MYLK) 100453783(MYLK2)
MCC: 
707361(MYLK4) 712830 715422(MYLK) 716132(MYLK3)
MCF: 
102122026(MYLK4) 102130711(MYLK) 102132754(MYLK3) 102145766(MYLK2)
MMU: 
107589(Mylk) 213435(Mylk3) 228785(Mylk2) 238564(Mylk4)
RNO: 
100911165(Mylk4) 117558(Mylk2) 288057(Mylk) 291926(Mylk3)
CGE: 
HGL: 
101697894(Mylk3) 101701713(Mylk4) 101704236(Mylk) 101712444(Mylk2)
TUP: 
102468205(MYLK3) 102476504(MYLK) 102489117(MYLK2) 102498032(MYLK4)
CFA: 
475345(MYLK3) 477187(MYLK2) 488012(MYLK) 488190(MYLK4)
AML: 
FCA: 
101088408(MYLK4) 101091744(MYLK3) 101095813(MYLK2) 494213
BTA: 
338037(MYLK) 518025(MYLK4) 526379(MYLK3) 533378(MYLK2)
BOM: 
102264349(MYLK4) 102269080(MYLK) 102275601(MYLK3) 102276600(MYLK2)
PHD: 
102331525(MYLK2) 102337475(MYLK) 102337545(MYLK3)
CHX: 
102181454(MYLK4) 102181980(MYLK3) 102182147(MYLK2) 102190641(MYLK)
SSC: 
100157526(MYLK4) 100524288(MYLK2) 396848(MYLK)
CFR: 
102505869(MYLK2) 102511426(MYLK3) 102515628(MYLK4) 102518144(MYLK)
ECB: 
100050092(MYLK4) 100053698(MYLK2) 100056559(MYLK3) 100070482(MYLK)
MYB: 
MDO: 
SHR: 
100915288(MYLK2) 100925131(MYLK3) 100930073(MYLK)
OAA: 
GGA: 
396356(MYLK2) 396445(MYLK) 415748(MYLK3) 420893(MYLK4) 428278
MGP: 
TGU: 
FAB: 
PHI: 
102101059 102104582(MYLK2) 102106790(MYLK) 102111091(MYLK4) 102112254(MYLK3)
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
102369318(MYLK2) 102371849(MYLK3) 102381743(MYLK) 102384108(MYLK4) 102387857
PSS: 
102448460(MYLK4) 102458914(MYLK3) 102461616(MYLK)
ACS: 
XTR: 
DRE: 
100003770 449707(mylk4b) 492576(mylkb) 558685(mlck2) 561635(mylk3) 566845 569510(mylka)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
413190(GB14586)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_ZC373.4(ZC373.4)
CBR: 
BMY: 
LOA: 
NVE: 
TAD: 
PFA: 
PFH: 
PYO: 
PBE: 
PKN: 
PVX: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K
  Title
Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction.
  Journal
IUBMB Life 51:337-44 (2001)
Reference
PMID:8810874
  Authors
Kohama K, Ye LH, Hayakawa K, Okagaki T
  Title
Myosin light chain kinase: an actin-binding protein that regulates an ATP-dependent interaction with myosin.
  Journal
Trends Pharmacol Sci 17:284-7 (1996)

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