KEGG   ORTHOLOGY: K01099Help
Entry
K01099                      KO                                     

Name
INPP5B_F
Definition
inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
Disease
H00692  Lowe syndrome
H00694  Dent disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Environmental Information Processing
  Signal transduction
   04070 Phosphatidylinositol signaling system
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.36  phosphoinositide 5-phosphatase
     K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Endocytosis
  Clathrin-mediated endocytosis
   Inositol 5-phosphatases
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
  Rab GTPases and associated proteins
   Rab associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Protein recycling
  Rab GTPases and associated proteins
   Others
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Endosome - Golgi transport
  Rab GTPases and associated proteins
   Rab associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
BRITE hierarchy
Other DBs
RN: R04404 R09827
GO: 0004439
Genes
HSA: 3633(INPP5B) 4952(OCRL)
PTR: 456767(INPP5B) 465851(OCRL)
PPS: 100972826(INPP5B) 100988033(OCRL)
GGO: 101138003(INPP5B) 101141428(OCRL)
PON: 100172875(OCRL) 100462526(INPP5B)
NLE: 100599622(INPP5B) 100603753(OCRL)
MCC: 702345(OCRL) 716851(INPP5B)
MCF: 101864788 102144048(OCRL)
CSAB: 103225081(INPP5B) 103232534(OCRL)
RRO: 104653630(INPP5B) 104655368(OCRL)
RBB: 108516495(OCRL) 108542199(INPP5B)
CJC: 100393539(INPP5B) 100415106(OCRL)
SBQ: 101036249(INPP5B) 101038137(OCRL)
MMU: 16330(Inpp5b) 320634(Ocrl)
RNO: 103689941 317576(Ocrl) 362590(Inpp5b)
CGE: 100751850(Inpp5b) 100774848(Ocrl)
NGI: 103728746(Ocrl) 103747699(Inpp5b)
HGL: 101704216(Inpp5b) 101722262(Ocrl)
OCU: 100346052(OCRL) 100350043(INPP5B)
TUP: 102476402(INPP5B) 102497673(OCRL)
CFA: 100686373(INPP5B) 492123(OCRL)
AML: 100476961(OCRL) 100482018(INPP5B)
UMR: 103666367(INPP5B) 103667611(OCRL)
ORO: 101372290(INPP5B) 101379029(OCRL)
FCA: 101092699(INPP5B) 101101038(OCRL)
PTG: 102964378(INPP5B) 102965696(OCRL)
AJU: 106973196(INPP5B) 106981590(OCRL)
BTA: 535844(OCRL) 538291(INPP5B)
BOM: 102274367(INPP5B) 102278951(OCRL)
BIU: 109555222(OCRL) 109556479(INPP5B)
PHD: 102328702(INPP5B) 102338669(OCRL)
CHX: 102173254(INPP5B) 102173924(OCRL)
OAS: 101119358(INPP5B) 101119794(OCRL)
SSC: 100512110(INPP5B) 100524726(OCRL)
CFR: 102506558(INPP5B) 102521852(OCRL)
CDK: 105086922(INPP5B) 105098825(OCRL)
BACU: 103005365(INPP5B) 103015114(OCRL)
LVE: 103085051 103086884(OCRL) 103091471(INPP5B)
OOR: 101270852(INPP5B) 101279498(OCRL) 101284777
ECB: 100054559(INPP5B) 100059144(OCRL)
EPZ: 103549507(INPP5B) 103561753(OCRL)
EAI: 106830567(INPP5B) 106847107(OCRL)
MYB: 102242464(OCRL) 102247367(INPP5B)
MYD: 102754754(OCRL) 102759168(INPP5B)
HAI: 109388879(OCRL) 109390984(INPP5B)
RSS: 109444860(INPP5B) 109447678(OCRL)
PALE: 102884156(OCRL) 102894285(INPP5B)
LAV: 100655464(OCRL) 100668271(INPP5B)
MDO: 100021521(OCRL) 100031802(INPP5B)
SHR: 100914199(INPP5B) 100917371(OCRL)
OAA: 100081303(INPP5B) 100087165(OCRL)
GGA: 419609(INPP5B) 422136(OCRL)
MGP: 100540459(INPP5B) 100543414(OCRL)
CJO: 107312534(OCRL) 107324005(INPP5B)
APLA: 101802967(INPP5B) 101803505(OCRL)
ACYG: 106037733(OCRL) 106038058(INPP5B)
TGU: 100219842(OCRL) 100220826(INPP5B) 100224437
GFR: 102033400(OCRL) 102043869(INPP5B)
FAB: 101809360(INPP5B) 101813228(OCRL)
PHI: 102100258(INPP5B) 102104956(OCRL)
PMAJ: 107204051(OCRL) 107214255(INPP5B)
CCW: 104691587(OCRL) 104694716(INPP5B)
FPG: 101911635(OCRL) 101917096(INPP5B)
FCH: 102048833(INPP5B) 102051014(OCRL)
CLV: 102088002(OCRL) 102089265(INPP5B)
EGZ: 104121748(OCRL) 104129194(INPP5B)
AAM: 106484102(OCRL) 106490910(INPP5B)
ASN: 102382497(INPP5B) 102386023(OCRL)
AMJ: 102558549(INPP5B) 102571633(OCRL)
PSS: 102449725(INPP5B) 102460113(OCRL)
CMY: 102936655(INPP5B) 102939662(OCRL)
CPIC: 101936637(INPP5B) 101937608(OCRL)
ACS: 100555494(inpp5b) 100563751(ocrl)
PVT: 110082772(INPP5B) 110084940(OCRL)
PBI: 103056566(INPP5B) 103058036(OCRL)
GJA: 107106064(OCRL) 107110144(INPP5B)
XLA: 100381066(inpp5b.L) 100873161(ocrl.L) 108700111(ocrl.S)
XTR: 100125214(ocrl) 100497120(inpp5b)
NPR: 108789553(INPP5B) 108793001(OCRL)
DRE: 563543(inpp5b) 777716(ocrl)
IPU: 108269006(ocrl) 108269428(inpp5b)
AMEX: 103027958(ocrl) 103029810(inpp5b)
TRU: 101070368(ocrl) 101074672(inpp5b)
LCO: 104919570(inpp5b) 104919860(ocrl)
NCC: 104941350 104941351(ocrl) 104965867(inpp5b)
MZE: 101465648(inpp5b) 101480849(ocrl)
OLA: 101162611(ocrl) 101170302(inpp5b)
XMA: 102228425(inpp5b) 102228444(ocrl)
PRET: 103471562(ocrl) 103477873(inpp5b)
NFU: 107377925(ocrl) 107379367(inpp5b)
CSEM: 103387904(inpp5b) 103390532(ocrl)
LCF: 108895406(ocrl) 108898729(inpp5b)
HCQ: 109513101(inpp5b) 109515772(ocrl)
BPEC: 110158945(ocrl) 110174323(inpp5b)
ELS: 105006615(ocrl) 105027176(inpp5b)
SFM: 108923154(ocrl) 108927714(inpp5b) 108931048
LCM: 102349621(OCRL) 102364570(INPP5B)
CMK: 103177560(ocrl) 103179631(inpp5b)
CIN: 100177344
SPU: 592451
APLC: 110984507
SKO: 100377456
DME: Dmel_CG3573(Ocrl)
DSI: Dsimw501_GD27106(Dsim_GD27106)
MDE: 101897751
AAG: 5577228
AME: 412731
BIM: 100741804
BTER: 100651293
SOC: 105195069
AEC: 105147360
ACEP: 105624817
PBAR: 105424913
HST: 105187545
CFO: 105258604
LHU: 105669453
PGC: 109860124
NVI: 100121409
TCA: 661520
DPA: 109546616
NVL: 108560079
BMOR: 101735658
PMAC: 106712764
PRAP: 110991324
PXY: 105381791
API: 100159919(INPP5B)
DNX: 107173728
ZNE: 110835651
TUT: 107362481
CEL: CELE_C16C2.3(ocrl-1)
CBR: CBG03815(Cbr-ocrl-1)
BMY: Bm1_48265
TSP: Tsp_10203
CRG: 105319752
MYI: 110452975
OBI: 106875100
EPA: 110237303
ADF: 107355825
CSAT: 104763495
CPAP: 110820300
EGR: 104453633
VRA: 106756783
CCAJ: 109790688
ADU: 107493305
LJA: Lj2g3v1022530.3(Lj2g3v1022530.3) Lj5g3v0614830.1(Lj5g3v0614830.1) Lj5g3v0614830.2(Lj5g3v0614830.2)
PXB: 103950660
ZJU: 107415454
CPEP: 111794032
POP: 7482428
JRE: 109008938
VVI: 100854877
SOT: 102605375
HAN: 110890653
LSV: 111891919
DCR: 108206712
BVG: 104887439
SOE: 110777538
NNU: 104586498
DCT: 110096594
SMO: SELMODRAFT_171623(IP5P4-2) SELMODRAFT_91806(IP5P4-1)
SLB: AWJ20_4283(INP51)
NCR: NCU01047
NTE: NEUTE1DRAFT120100(NEUTE1DRAFT_120100)
MGR: MGG_16389
MAW: MAC_05568
MAJ: MAA_10636
CMT: CCM_09079
MBE: MBM_08782
ANI: AN7745.2
ANG: ANI_1_1322034(An03g03860)
ABE: ARB_06083
TVE: TRV_00303
PTE: PTT_13819
ABP: AGABI1DRAFT121436(AGABI1DRAFT_121436)
ABV: AGABI2DRAFT187599(AGABI2DRAFT_187599)
DDI: DDB_G0267462(Dd5P4)
DFA: DFA_07655(Dd5P4)
EHI: EHI_153490(13.t00027) EHI_159880(256.t00004)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Williams C, Choudhury R, McKenzie E, Lowe M
  Title
Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway.
  Journal
J Cell Sci 120:3941-51 (2007)
DOI:10.1242/jcs.014423
  Sequence
[hsa:3633]
Reference
  Authors
van Rahden VA, Brand K, Najm J, Heeren J, Pfeffer SR, Braulke T, Kutsche K
  Title
The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.
  Journal
Hum Mol Genet 21:5019-38 (2012)
DOI:10.1093/hmg/dds343
  Sequence
[hsa:4952]

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