KEGG   ORTHOLOGY: K01110Help
Entry
K01110                      KO                                     

Name
PTEN
Definition
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Pathway
Inositol phosphate metabolism
FoxO signaling pathway
Phosphatidylinositol signaling system
p53 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Tight junction
Hepatitis B
Pathways in cancer
MicroRNAs in cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Small cell lung cancer
Central carbon metabolism in cancer
Disease
H00013  
Small cell lung cancer
H00024  
Prostate cancer
H00026  
Endometrial Cancer
H00029  
Vulvar cancer
H00031  
Breast cancer
H00038  
Malignant melanoma
H00042  
Glioma
H00048  
Hepatocellular carcinoma
H01195  
VACTERL/VATER association
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04070 Phosphatidylinositol signaling system
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04151 PI3K-Akt signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04150 mTOR signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 Cellular Processes
  Cell growth and death
   04115 p53 signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  Cellular commiunity
   04510 Focal adhesion
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04530 Tight junction
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05230 Central carbon metabolism in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05206 MicroRNAs in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05214 Glioma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05218 Melanoma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05215 Prostate cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05213 Endometrial cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05222 Small cell lung cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  Infectious diseases
   05161 Hepatitis B
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    3.1.3.48  protein-tyrosine-phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
BRITE hierarchy
Other DBs
Genes
HSA: 
5728(PTEN)
PTR: 
466142(PTEN)
PPS: 
100983152(PTEN)
GGO: 
101147526(PTEN)
PON: 
100171828(PTEN)
NLE: 
MCC: 
705121(PTEN)
MCF: 
CJC: 
100393460(PTEN)
MMU: 
19211(Pten)
RNO: 
50557(Pten)
CGE: 
100764294(Pten)
NGI: 
103738044(Pten)
HGL: 
101714930(Pten)
OCU: 
100358716(PTEN)
TUP: 
102489114(PTEN)
CFA: 
403832(PTEN)
AML: 
UMR: 
103661921(PTEN)
FCA: 
101091813(PTEN)
PTG: 
102972446(PTEN)
BTA: 
540786(PTEN)
BOM: 
102268478(PTEN)
PHD: 
102337473(PTEN)
CHX: 
102185891(PTEN)
OAS: 
101119351(PTEN)
SSC: 
100156264(PTEN)
CFR: 
102515104(PTEN)
BACU: 
102998704(PTEN)
LVE: 
103074298(PTEN)
ECB: 
100062388(PTEN)
MYB: 
102257838(PTEN)
MYD: 
102755323(PTEN)
PALE: 
102881949(PTEN)
MDO: 
100013036(PTEN)
SHR: 
OAA: 
100074365(PTEN)
GGA: 
423675(PTEN)
MGP: 
APLA: 
101798136(PTEN)
TGU: 
100224148(PTEN)
FAB: 
101815785(PTEN)
PHI: 
102106703(PTEN)
FPG: 
101912177(PTEN)
FCH: 
102050194(PTEN)
CLV: 
102094724(PTEN)
ASN: 
102377424(PTEN)
AMJ: 
102558284(PTEN)
PSS: 
102443573(PTEN)
CMY: 
102941367(PTEN)
ACS: 
100552870(pten)
PBI: 
XLA: 
XTR: 
100144716(pten)
DRE: 
368415(ptenb) 794088(ptena)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102348548(PTEN)
CMK: 
103180851(pten)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AME: 
411859(Pten)
NVI: 
100117148(Pten)
TCA: 
BMOR: 
API: 
100163194(Pten)
PHU: 
ISC: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT3G19420(PEN2) AT3G50110(PEN3) AT5G39400(PTEN1)
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0001s30940g(POPTRDRAFT_707340) POPTR_0007s10610g(POPTRDRAFT_1083067) POPTR_0009s10080g(POPTRDRAFT_722258) POPTR_0017s12540g(POPTRDRAFT_259295)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os12t0407500-01(Os12g0407500)
OBR: 
BDI: 
SBI: 
SORBI_02g000980(SORBIDRAFT_02g000980)
ZMA: 
SITA: 
PDA: 
MUS: 
ATR: 
s00051p00218610(AMTR_s00051p00218610) s00177p00053100(AMTR_s00177p00053100)
SMO: 
PPP: 
CRE: 
CSL: 
SPO: 
WSE: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_06571(pten)
EHI: 
EHI_197010(92.t00018)
EDI: 
ACAN: 
TET: 
PTM: 
PIF: 
EHX: 
GTT: 
TCR: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Song MS, Salmena L, Pandolfi PP
  Title
The functions and regulation of the PTEN tumour suppressor.
  Journal
Nat Rev Mol Cell Biol 13:283-96 (2012)

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