KEGG   ORTHOLOGY: K01371Help
Entry
K01371                      KO                                     

Name
CTSK
Definition
cathepsin K [EC:3.4.22.38]
Pathway
Lysosome
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
Disease
H00273  
Pycnodysostosis
H00425  
Lysosomal cysteine protease deficiencies
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Transport and catabolism
   04142 Lysosome
    K01371  CTSK; cathepsin K
  Cell growth and death
   04210 Apoptosis
    K01371  CTSK; cathepsin K
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K01371  CTSK; cathepsin K
  Development
   04380 Osteoclast differentiation
    K01371  CTSK; cathepsin K
 Human Diseases
  Immune diseases
   05323 Rheumatoid arthritis
    K01371  CTSK; cathepsin K
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.38  cathepsin K
     K01371  CTSK; cathepsin K
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C1: papain family
   K01371  CTSK; cathepsin K
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Papain family
   K01371  CTSK; cathepsin K
BRITE hierarchy
Genes
HSA: 
1513(CTSK)
PTR: 
457278(CTSK)
PPS: 
100974656(CTSK)
GGO: 
101145486(CTSK)
PON: 
100432447(CTSK)
NLE: 
100580351(CTSK)
MCC: 
574112(CTSK)
MCF: 
102120416(CTSK)
RRO: 
104681068(CTSK)
CJC: 
100410169(CTSK)
MMU: 
13038(Ctsk)
RNO: 
29175(Ctsk)
CGE: 
100765407(Ctsk)
NGI: 
103729102(Ctsk)
HGL: 
101716993(Ctsk)
OCU: 
100009334(CTSK)
TUP: 
102469152(CTSK)
CFA: 
608843(CTSK)
AML: 
100483004(CTSK)
UMR: 
103667534(CTSK)
FCA: 
101093379(CTSK)
PTG: 
102968588(CTSK)
BTA: 
513038(CTSK)
BOM: 
102287709(CTSK)
PHD: 
102332396(CTSK)
CHX: 
102183473(CTSK)
OAS: 
101108972(CTSK)
SSC: 
397569(CTSK)
CFR: 
102511322(CTSK)
BACU: 
103008252(CTSK)
LVE: 
103075087(CTSK)
ECB: 
100054991(CTSK)
MYB: 
102259503(CTSK)
MYD: 
102771486(CTSK)
PALE: 
102885198(CTSK)
MDO: 
100017449(CTSK)
SHR: 
100917440(CTSK)
OAA: 
100088286(CTSK)
GGA: 
395818(CTSK)
MGP: 
104914440(CTSK)
APLA: 
101794155(CTSK)
GFR: 
102031691(CTSK)
PHI: 
102102166(CTSK)
FPG: 
101919682(CTSK)
FCH: 
102049655(CTSK)
CLV: 
102096035(CTSK)
AAM: 
106495413(CTSK)
AMJ: 
102575411(ARNT)
PSS: 
CMY: 
ACS: 
100561728(ctsk)
PBI: 
103053602(CTSK)
GJA: 
107120548(CTSK)
XLA: 
100127265(ctsk)
XTR: 
448216(ctsk) 779889(ctsk)
DRE: 
550475(ctsk)
TRU: 
101066261(ctsk)
MZE: 
OLA: 
XMA: 
LCM: 
DME: 
DAN: 
TCA: 
BMY: 
LOA: 
LGI: 
ALY: 
CRB: 
EUS: 
SLY: 
101251145(Rcr3)
SPEN: 
107009508(Rcr3)
DFA: 
EIV: 
TET: 
PTM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H
  Title
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
  Journal
Science 319:624-7 (2008)
Reference
PMID:8703060
  Authors
Gelb BD, Shi GP, Chapman HA, Desnick RJ
  Title
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.
  Journal
Science 273:1236-8 (1996)
Reference
  Authors
Tepel C, Bromme D, Herzog V, Brix K
  Title
Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.
  Journal
J Cell Sci 113 Pt 24:4487-98 (2000)
  Sequence
[mmu:13038]

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