KEGG   ORTHOLOGY: K01379Help
Entry
K01379                      KO                                     

Name
CTSD
Definition
cathepsin D [EC:3.4.23.5]
Pathway
Sphingolipid signaling pathway
Lysosome
Apoptosis
Tuberculosis
Disease
H00149  
Neuronal ceroid lipofuscinosis
H00810  
Progressive myoclonic epilepsy (PME/ EPM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04071 Sphingolipid signaling pathway
    K01379  CTSD; cathepsin D
 Cellular Processes
  Transport and catabolism
   04142 Lysosome
    K01379  CTSD; cathepsin D
  Cell growth and death
   04210 Apoptosis
    K01379  CTSD; cathepsin D
 Human Diseases
  Infectious diseases
   05152 Tuberculosis
    K01379  CTSD; cathepsin D
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.5  cathepsin D
     K01379  CTSD; cathepsin D
Peptidases [BR:ko01002]
 Aspartic Peptidases
  Family A1: pepsin family
   K01379  CTSD; cathepsin D
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01379  CTSD; cathepsin D
BRITE hierarchy
Genes
HSA: 
1509(CTSD)
PTR: 
746637(CTSD)
PPS: 
100974319(CTSD)
GGO: 
101125251(CTSD)
PON: 
100172401(CTSD)
NLE: 
100582697(CTSD)
MCC: 
703534(CTSD)
MCF: 
102125635(CTSD)
RRO: 
104677092(CTSD)
CJC: 
100397061(CTSD)
MMU: 
13033(Ctsd)
RNO: 
171293(Ctsd)
CGE: 
100766628(Ctsd)
NGI: 
103738995(Ctsd)
HGL: 
101716979(Ctsd)
OCU: 
100101595(CTSD)
TUP: 
102474582(CTSD)
CFA: 
483662(CTSD)
AML: 
100464994(CTSD)
UMR: 
103671118(CTSD)
FCA: 
101094625(CTSD)
PTG: 
102954120(CTSD)
BTA: 
282883(CTSD)
BOM: 
102275829(CTSD)
PHD: 
102343491(CTSD)
CHX: 
SSC: 
494568(CTSD)
CFR: 
102523939(CTSD)
BACU: 
103017977(CTSD)
LVE: 
103083086(CTSD)
MYB: 
102255890(CTSD)
MYD: 
102752567(CTSD)
PALE: 
102888325(CTSD)
SHR: 
100917285(CTSD)
OAA: 
GGA: 
396090(RP11-295K3.1)
MGP: 
100543618(CTSD)
APLA: 
101792449(CTSD)
TGU: 
100232592(CTSD)
GFR: 
102032764(CTSD)
FAB: 
101814740(CTSD)
PHI: 
CCW: 
104688249(CTSD)
FPG: 
101917516(CTSD)
FCH: 
102054100(CTSD)
CLV: 
102090198(CTSD)
ASN: 
102387475(NAPSA) 102387859(CTSD)
AMJ: 
PSS: 
102448444(CTSD)
CMY: 
102948221(CTSD)
ACS: 
PBI: 
XLA: 
398557 398994(napsa) 443721(ctsd) 443829
XTR: 
394561(ctsd) 448214(napsa) 493534 613063
DRE: 
336746(fa94d12) 65225(ctsd)
TRU: 
777955(ctsd) 777956(ctsd2)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103174885(ctsd)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DWI: 
DYA: 
Dyak_GE10127(dyak_GLEANR_10080) Dyak_GE10128(dyak_GLEANR_10081) Dyak_GE10129(dyak_GLEANR_10082) Dyak_GE10927(Dyak_CG13095) Dyak_GE13586(dyak_GLEANR_13783) Dyak_GE17582(dyak_GLEANR_1890) Dyak_GE17593(dyak_GLEANR_1891) Dyak_GE17604(dyak_GLEANR_1892) Dyak_GE17615(dyak_GLEANR_1893) Dyak_GE18490(dyak_GLEANR_2278) Dyak_GE18491(dyak_GLEANR_2279) Dyak_GE23596(dyak_GLEANR_737)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
AaeL_AAEL006169(ASPP_AEDAE)
CQU: 
AME: 
409341(cathD)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
692768(CatD)
PXY: 
API: 
100168373(Cathd)
PHU: 
ISC: 
CEL: 
CBR: 
CBG05258(Cbr-asp-4) CBG10895(Cbr-asp-3)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
BRP: 
BNA: 
BVG: 
CME: 
AFM: 
ZTR: 
PFJ: 
TMS: 
PPL: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT112343(AGABI1DRAFT_112343) AGABI1DRAFT91098(AGABI1DRAFT_91098)
ABV: 
AGABI2DRAFT142735(AGABI2DRAFT_142735) AGABI2DRAFT192307(AGABI2DRAFT_192307)
CPUT: 
SLA: 
WSE: 
PGR: 
MLR: 
SRE: 
DDI: 
DPP: 
DFA: 
DFA_06766(ctsD)
PCB: 
PVX: 
PCY: 
TET: 
PTM: 
TPS: 
AAF: 
NGD: 
EHX: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7341918
  Authors
Takahashi T, Tang J
  Title
Cathepsin D from porcine and bovine spleen.
  Journal
Methods Enzymol 80 Pt C:565-81 (1981)
Reference
  Authors
Sevlever D, Jiang P, Yen SH
  Title
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.
  Journal
Biochemistry 47:9678-87 (2008)
  Sequence
[hsa:1509]

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