KEGG   ORTHOLOGY: K01403Help
Entry
K01403                      KO                                     

Name
MMP9
Definition
matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
Pathway
Endocrine resistance
IL-17 signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Estrogen signaling pathway
Hepatitis B
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Bladder cancer
Fluid shear stress and atherosclerosis
Disease
H00025  
Penile cancer
H00479  
Metaphyseal dysplasias
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04668 TNF signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
 Organismal Systems
  Immune system
   04657 IL-17 signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   04670 Leukocyte transendothelial migration
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  Endocrine system
   04915 Estrogen signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05202 Transcriptional misregulation in cancers
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05206 MicroRNAs in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05205 Proteoglycans in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05219 Bladder cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  Infectious diseases
   05161 Hepatitis B
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  Drug resistance
   01522 Endocrine resistance
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.35  gelatinase B
     K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
Peptidases [BR:ko01002]
 Metallo Peptidases
  Family M10
   K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
BRITE hierarchy
Genes
HSA: 
4318(MMP9)
PTR: 
458294(MMP9)
PPS: 
100974722(MMP9)
GGO: 
101138361(MMP9)
PON: 
100455867(MMP9)
NLE: 
100587873(MMP9)
MCC: 
708084(MMP9)
MCF: 
102117693(MMP9)
CSAB: 
103245064(MMP9)
RRO: 
104678814(MMP9)
CJC: 
100415095(MMP9)
SBQ: 
101036569(MMP9)
MMU: 
17395(Mmp9)
RNO: 
81687(Mmp9)
CGE: 
100770707(Mmp9)
NGI: 
103751232(Mmp9)
HGL: 
101717243(Mmp9)
CCAN: 
109689278(Mmp9)
OCU: 
100008993(MMP9)
TUP: 
102487885(MMP9)
CFA: 
403885(MMP9)
AML: 
100475429(MMP9)
UMR: 
103669705(MMP9)
FCA: 
PTG: 
102959269(MMP9)
AJU: 
106969010(MMP9)
BTA: 
282871(MMP9)
BOM: 
102273141(MMP9)
BIU: 
109567506(MMP9)
PHD: 
102321866(MMP9)
CHX: 
102168469(MMP9)
OAS: 
100192422(MMP9)
SSC: 
654325(MMP9)
CFR: 
102509767(MMP9)
BACU: 
103016628(MMP9)
LVE: 
103086240(MMP9)
ECB: 
100056599(MMP9)
MYB: 
102260281(MMP9)
MYD: 
102765342(MMP9)
HAI: 
109379910(MMP9)
RSS: 
109457039(MMP9)
PALE: 
102889517(MMP9)
LAV: 
100664260(MMP9)
MDO: 
100022144(MMP9)
SHR: 
100934566(MMP9)
GGA: 
395387(MMP9)
MGP: 
100540313(MMP9)
CJO: 
107323128(MMP9)
APLA: 
101793782(MMP9)
TGU: 
100227728(MMP9)
GFR: 
102042403(MMP9)
FAB: 
101813444(MMP9)
PHI: 
102112681(MMP9)
CCW: 
104687728(MMP9)
FPG: 
101912755(MMP9)
FCH: 
102053895(MMP9)
CLV: 
102094215(MMP9)
AAM: 
106497585(MMP9)
ASN: 
102368987(MMP9)
AMJ: 
106736975(MMP9)
PSS: 
106732917(MMP9)
CMY: 
CPIC: 
101936391(MMP9)
ACS: 
PBI: 
103064710(MMP9)
GJA: 
XLA: 
100037129(mmp9.L) 108702732 379663(mmp9.S)
XTR: 
100494738(mmp9) 448591(mmp9)
DRE: 
406397(mmp9)
IPU: 
TRU: 
653023(mmp9)
TNG: 
LCO: 
104926671(mmp9)
MZE: 
101483885(mmp9)
OLA: 
100125420(mmp9)
XMA: 
102229854(mmp9)
CSEM: 
103384600(mmp9)
SASA: 
LCM: 
102358076(MMP9)
CMK: 
103191321(mmp9)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2551898
  Authors
Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI
  Title
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
  Journal
J Biol Chem 264:17213-21 (1989)
  Sequence
[hsa:4318]
Reference
  Authors
Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C
  Title
Matrix metalloproteinases: evolution, gene regulation and functional analysis in  mouse models.
  Journal
Biochim Biophys Acta 1803:3-19 (2010)
DOI:10.1016/j.bbamcr.2009.07.004
Reference
  Authors
Amalinei C, Caruntu ID, Balan RA
  Title
Biology of metalloproteinases.
  Journal
Rom J Morphol Embryol 48:323-34 (2007)
Reference
  Authors
Hua H, Li M, Luo T, Yin Y, Jiang Y
  Title
Matrix metalloproteinases in tumorigenesis: an evolving paradigm.
  Journal
Cell Mol Life Sci 68:3853-68 (2011)
DOI:10.1007/s00018-011-0763-x

DBGET integrated database retrieval system