Entry
Symbol
folB
Name
Pathway
Module
M00126 Tetrahydrofolate biosynthesis, GTP => THF
M00840 Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF
Reaction
R03504 7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
R11037 7,8-dihydroneopterin:oxygen oxidoreductase
R11073 7,8-dihydroneopterin 2'-epimerase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.13.11 With incorporation of two atoms of oxygen
1.13.11.81 7,8-dihydroneopterin oxygenase
K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase
4. Lyases
4.1 Carbon-carbon lyases
4.1.2 Aldehyde-lyases
4.1.2.25 dihydroneopterin aldolase
K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase
5. Isomerases
5.1 Racemases and epimerases
5.1.99 Acting on other compounds
5.1.99.8 7,8-dihydroneopterin epimerase
K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Lee SW, Lee HW, Chung HJ, Kim YA, Kim YJ, Hahn Y, Chung JH, Park YS
Title
Identification of the genes encoding enzymes involved in the early biosynthetic pathway of pteridines in Synechocystis sp. PCC 6803.
Journal
Sequence
Reference
Authors
Haussmann C, Rohdich F, Schmidt E, Bacher A, Richter G
Title
Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase.
Journal
Sequence
Reference
Authors
Goyer A, Illarionova V, Roje S, Fischer M, Bacher A, Hanson AD
Title
Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases.
Journal
Sequence
Reference
Authors
Czekster CM, Blanchard JS
Title
One substrate, five products: reactions catalyzed by the dihydroneopterin aldolase from Mycobacterium tuberculosis.
Journal
Sequence