KEGG   ORTHOLOGY: K01825Help
Entry
K01825                      KO                                     

Name
fadB
Definition
3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
Pathway
Fatty acid degradation
Valine, leucine and isoleucine degradation
Geraniol degradation
Lysine degradation
Tryptophan metabolism
beta-Alanine metabolism
Propanoate metabolism
Butanoate metabolism
Limonene and pinene degradation
Caprolactam degradation
Biosynthesis of unsaturated fatty acids
Carbon metabolism
Fatty acid metabolism
Module
M00032  
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00087  
beta-Oxidation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   01212 Fatty acid metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Carbohydrate metabolism
   00640 Propanoate metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   00650 Butanoate metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Lipid metabolism
   00071 Fatty acid degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   01040 Biosynthesis of unsaturated fatty acids
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   00310 Lysine degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   00380 Tryptophan metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Metabolism of terpenoids and polyketides
   00903 Limonene and pinene degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
   00281 Geraniol degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Fatty acid metabolism
    M00087  beta-Oxidation
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  Nucleotide and amino acid metabolism
   Lysine metabolism
    M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.2  Acting on hydroxy acids and derivatives
    5.1.2.3  3-hydroxybutyryl-CoA epimerase
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.8  dodecenoyl-CoA isomerase
     K01825  fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase
BRITE hierarchy
Other DBs
Genes
ECO: 
b3846(fadB)
ECJ: 
Y75_p3334(fadB)
ECD: 
EBW: 
BWG_3522(fadB)
ECOK: 
ECE: 
Z5367(fadB)
ECS: 
ECs4774(fadB)
ECF: 
ETW: 
ECSP_4899(fadB)
ELX: 
EOJ: 
EOI: 
EOH: 
ECG: 
EOK: 
ELR: 
ECC: 
c4793(fadB)
ECP: 
ECP_4059(fadB)
ECI: 
ECV: 
ECX: 
ECW: 
ECM: 
ECY: 
ECSE_4132(fadB)
ECR: 
ECQ: 
ECK: 
ECT: 
EOC: 
CE10_4505(fadB)
EUM: 
ECZ: 
ELO: 
ELN: 
ELH: 
ESE: 
ESO: 
O3O_00700(fadB)
ESM: 
O3M_24555(fadB)
ESL: 
O3K_24635(fadB)
ECL: 
EBR: 
ECB_03737(fadB)
EBD: 
ECBD_4179(fadB)
EKO: 
EKF: 
EAB: 
EDH: 
EDJ: 
EIH: 
ENA: 
ELU: 
EUN: 
ELW: 
ECW_m4146(fadB)
ELL: 
WFL_20230(fadB)
ELC: 
i14_4387(fadB)
ELD: 
i02_4387(fadB)
ELP: 
EBL: 
ECD_03737(fadB)
EBE: 
B21_03686(fadB)
ELF: 
LF82_0614(fadB)
ECOA: 
ECOL: 
ECOI: 
ECOJ: 
ECOO: 
ECOH: 
EFE: 
EFER_3635(fadB)
STY: 
STY3577(fadB)
STT: 
t3315(fadB)
SEX: 
SENT: 
STM: 
STM3983(fadB)
SEO: 
SEV: 
SEY: 
SEM: 
SEJ: 
SEB: 
SEF: 
SETU: 
SETC: 
SEEN: 
SENR: 
SEND: 
SENI: 
SPT: 
SPA3823(fadB)
SEK: 
SSPA3560(fadB)
SPQ: 
SEI: 
SPC_4090(fadB)
SEC: 
SC3880(fadB)
SEH: 
SHB: 
SENH: 
SEEH: 
SEE: 
SENN: 
SEW: 
SEA: 
SENS: 
SED: 
SeD_A4369(fadB)
SEG: 
SG3469(fadB)
SEL: 
SPUL_3449(fadB)
SEGA: 
SET: 
SEN3777(fadB)
SENJ: 
SEEC: 
SEEB: 
SEEP: 
SENB: 
BN855_40540(SBOV40601)
SENE: 
IA1_19355(fadB)
SES: 
SBG: 
SBG_3514(fadB)
SBZ: 
SBV: 
YPE: 
YPO3766(fadB)
YPK: 
y0464(fadB)
YPA: 
YPA_3436(fadB)
YPN: 
YPN_0198(fadB)
YPM: 
YP_3282(fadB)
YPP: 
YPG: 
YPZ: 
YPZ3_3324(fadB)
YPT: 
YPD: 
YPD4_3315(fadB)
YPX: 
YPD8_3316(fadB)
YPH: 
YPC_0474(fadB)
YPS: 
YPTB0267(fadB)
YPI: 
YPY: 
YPK_3933(fadB)
YPB: 
YPTS_0283(fadB)
YPQ: 
DJ40_2154(fadB)
YEN: 
YE0268(fadB)
YEP: 
YEY: 
YEL: 
YEW: 
CH47_3217(fadB)
YET: 
CH48_1966(fadB)
YSI: 
YAL: 
AT01_2202(fadB)
YFR: 
AW19_2936(fadB)
YIN: 
CH53_2071(fadB)
YKR: 
CH54_2852(fadB)
YRO: 
CH64_2859(fadB)
YRU: 
BD65_1676(fadB)
SFL: 
SF3922(fadB)
SFX: 
S3830(fadB)
SFV: 
SFV_3654(fadB)
SFE: 
SFxv_4275(fadB)
SFN: 
SFS: 
SSN: 
SSON_4019(fadB)
SSJ: 
SBC: 
SDY: 
SDY_3899(fadB)
SDZ: 
ECA: 
ECA0208(fadB)
PATR: 
PATO: 
PCT: 
PCC: 
PCV: 
PWA: 
PEC: 
ETA: 
ETA_02460(fadB)
EPY: 
EpC_02330(fadB)
EPR: 
EAM: 
EAMY_0223(fadB)
EAY: 
EAM_0213(fadB)
EBI: 
EbC_02440(fadB)
ERJ: 
PLU: 
plu4402(fadB)
PAY: 
PAU_03873(fadB)
ENT: 
ENC: 
ENO: 
ECLO: 
EEC: 
ENL: 
ECLA: 
ECLC: 
ECLG: 
ECLE: 
ECLN: 
ESC: 
EAS: 
EAU: 
EAE: 
EAE_08050(fadB)
EAR: 
ENR: 
ESA: 
ESA_03714(fadB)
CSK: 
ES15_3645(fadB)
CSZ: 
CSI: 
CTU: 
CTU_02770(fadB)
KPN: 
KPN_04340(fadB)
KPU: 
KP1_0203(fadB)
KPM: 
KPP: 
KPK: 
KPH: 
KPZ: 
KPW: 
KPY: 
KPG: 
KPQ: 
KPT: 
KPE: 
KPK_5333(fadB)
KPO: 
KPR: 
KPR_0289(fadB)
KPJ: 
KPI: 
KPA: 
KPS: 
KPX: 
KPB: 
KVA: 
KVD: 
KVQ: 
KOX: 
KOX_07835(fadB)
KOE: 
KOY: 
KOK: 
KOM: 
CKO: 
CKO_00188(fadB)
CRO: 
ROD_39091(fadB)
CFD: 
SPE: 
Spro_0261(fadB)
SRR: 
SRL: 
SRY: 
SRS: 
SRA: 
SMAF: 
SMW: 
SMAR: 
SM39_4246(fadB)
SLQ: 
SERR: 
SFO: 
SERF: 
SERS: 
PMR: 
PMI3550(fadB)
PMIB: 
DDA: 
DDC: 
DDD: 
DZE: 
DZC: 
XBO: 
XBJ1_0517(fadB)
XNE: 
XNC1_3875(fadB)
PAM: 
PANA_0201(fadB)
PLF: 
PAJ: 
PAJ_3361(fadB)
PAQ: 
PVA: 
Pvag_3442(fadB)
PAO: 
KLN: 
PANT: 
PANP: 
RAH: 
RAQ: 
RAA: 
Q7S_21080(fadB)
PSI: 
S70_07695(fadB)
PSX: 
DR96_1634(fadB)
EBT: 
MMK: 
ROR: 
RON: 
CNT: 
CEM: 
CEN: 
CED: 
PGE: 
HAV: 
KSA: 
EBF: 
PSTS: 
VCH: 
VC2758(fadB)
VCE: 
VCJ: 
VCO: 
VCR: 
VCM: 
VCI: 
O3Y_13185(fadB)
VCL: 
VCQ: 
VVU: 
VV1_0981(fadB)
VVY: 
VV0029(fadB)
VVM: 
VVL: 
VPA: 
VP0030(fadB)
VPB: 
VPK: 
VPF: 
VPH: 
VHA: 
VCA: 
VAG: 
VSP: 
VS_0041(fadB)
VEX: 
VEJ: 
VFU: 
VNI: 
VAN: 
LAG: 
VCY: 
VCT: 
VTU: 
VFI: 
VF_0025(fadB)
VFM: 
VSA: 
PPR: 
PBPRA0064(fadB)
PAE: 
PA3014(faoA)
PAEV: 
N297_3120(fadB)
PAEI: 
N296_3120(fadB)
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
BN889_03366(fadB_1) BN889_03367(fadB_2)
PAEG: 
PAEC: 
M802_3117(fadB)
PAEO: 
M801_2985(fadB)
PPU: 
PP_2136(fadB)
PPF: 
Pput_3606(fadB)
PPG: 
PPW: 
PPT: 
PPB: 
PPI: 
PPX: 
T1E_0604(fadB)
PPUH: 
PPUT: 
PPUN: 
PP4_37140(fadB)
PPUD: 
PFV: 
PMON: 
PMOT: 
PMOS: 
PST: 
PSB: 
Psyr_3290(fadB)
PSYR: 
PSP: 
PCI: 
PFL: 
PFL_1940(fadB)
PPRC: 
PPRO: 
PPC_2011(fadB)
PFO: 
PFS: 
PFLU1553(fadB)
PFE: 
PFC: 
PFN: 
PPZ: 
PMAN: 
OU5_5470(fadB)
PEN: 
PSEEN3728(fadB)
PMY: 
Pmen_1580(fadB)
PMK: 
PSA: 
PST_1726(fadB)
PSZ: 
PSR: 
PSC: 
PSJ: 
PSH: 
PSTU: 
PSTT: 
PBM: 
PBA: 
PBC: 
PPUU: 
PDR: 
PRE: 
PSV: 
PSK: 
PKC: 
PKB_3787(fadB)
PCH: 
PCP: 
PALK: 
PRH: 
PSW: 
PPV: 
PSES: 
PSCI_5482(fadB)
AVN: 
AVL: 
AvCA_14440(fadB) AvCA_16390(fadB2)
AVD: 
ACX: 
PAR: 
Psyc_1934(fadB)
PCR: 
PRW: 
PSO: 
ACI: 
ACIAD0335(fadB)
ACD: 
ABM: 
ABSDF3220(fadB)
ABY: 
ABAYE3470(fadB)
ABC: 
ABN: 
AB57_0387(fadB)
ABB: 
ABX: 
ABZ: 
ABR: 
ABD: 
ABH: 
ABAD: 
ABJ: 
ABAB: 
ABAJ: 
ABAZ: 
ABK: 
ABAU: 
ABAA: 
ABW: 
ABAL: 
ACC: 
MCT: 
MCR_0091(fadB)
MCS: 
DR90_1804(fadB)
MCAT: 
SON: 
SO_0021(fadB)
SDN: 
Sden_0015(fadB)
SFR: 
Sfri_0013(fadB)
SAZ: 
Sama_0032(fadB)
SBL: 
Sbal_0021(fadB)
SBM: 
SBN: 
SBP: 
SBT: 
SBS: 
SBB: 
SLO: 
Shew_0019(fadB)
SPC: 
SHP: 
SSE: 
Ssed_0023(fadB)
SPL: 
Spea_0018(fadB)
SHE: 
SHM: 
SHN: 
SHW: 
SHL: 
Shal_0016(fadB)
SWD: 
Swoo_0021(fadB)
SWP: 
swp_0035(fadB)
SVO: 
SVI_0052(fadB-1)
ILO: 
IL0011(fadB)
ILI: 
CPS: 
CPS_0393(fadB)
PHA: 
PSHAa0011(fadB)
PAT: 
Patl_0201(fadB)
PSM: 
PSM_A0012(fadB)
PSEO: 
SDE: 
MAQ: 
Maqu_1144(fadB)
MHC: 
MARHY2136(fadB)
MAD: 
MBS: 
MSX: 
AMC: 
AMAC: 
AMB: 
AMG: 
AMH: 
AMK: 
AMAA: 
AMAE: 
AMAO: 
AMAD: 
AMAI: 
AMAG: 
ALT: 
AAL: 
GAG: 
GNI: 
GNIT_2932(fadB)
GPS: 
TTU: 
FBL: 
HCH: 
HCH_04756(fadB)
CSA: 
Csal_2393(fadB)
HEL: 
HELO_1758(fadB)
HCS: 
ABO: 
ABO_1652(fadB)
ADI: 
B5T_01517(fadB)
APAC: 
S7S_12545(fadB)
KKO: 
Kkor_0013(fadB)
MMW: 
MME: 
MPC: 
TOL: 
TOR: 
AHA: 
AHA_0139(fadB)
AHY: 
AHD: 
AHR: 
AHP: 
AHJ: 
ASA: 
ASA_4250(fadB)
AVR: 
AMED: 
OCE: 
GU3_01845(fadB)
SAGA: 
M5M_01685(fadB) M5M_18535(fadB)
GPB: 
BCT: 
DAR: 
Daro_2350(fadB)
HOH: 
MSL: 
Msil_1395(fadB)
AZL: 
RBA: 
RB1092(faoA)
SACI: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Sato S, Nomura CT, Abe H, Doi Y, Tsuge T
  Title
Poly[(R)-3-hydroxybutyrate] formation in Escherichia coli from glucose through an enoyl-CoA hydratase-mediated pathway.
  Journal
J Biosci Bioeng 103:38-44 (2007)

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