KEGG   ORTHOLOGY: K02084Help
Entry
K02084                      KO                                     

Name
APAF1
Definition
apoptotic protease-activating factor
Pathway
ko01524  Platinum drug resistance
ko04115  p53 signaling pathway
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04215  Apoptosis - multiple species
ko05010  Alzheimer's disease
ko05012  Parkinson's disease
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05016  Huntington's disease
ko05134  Legionellosis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Module
M00685  Apoptotic machinery
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02084  APAF1; apoptotic protease-activating factor
   04214 Apoptosis - fly
    K02084  APAF1; apoptotic protease-activating factor
   04215 Apoptosis - multiple species
    K02084  APAF1; apoptotic protease-activating factor
   04115 p53 signaling pathway
    K02084  APAF1; apoptotic protease-activating factor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02084  APAF1; apoptotic protease-activating factor
   05222 Small cell lung cancer
    K02084  APAF1; apoptotic protease-activating factor
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K02084  APAF1; apoptotic protease-activating factor
   05012 Parkinson's disease
    K02084  APAF1; apoptotic protease-activating factor
   05014 Amyotrophic lateral sclerosis (ALS)
    K02084  APAF1; apoptotic protease-activating factor
   05016 Huntington's disease
    K02084  APAF1; apoptotic protease-activating factor
  Infectious diseases
   05134 Legionellosis
    K02084  APAF1; apoptotic protease-activating factor
   05152 Tuberculosis
    K02084  APAF1; apoptotic protease-activating factor
   05161 Hepatitis B
    K02084  APAF1; apoptotic protease-activating factor
  Drug resistance
   01524 Platinum drug resistance
    K02084  APAF1; apoptotic protease-activating factor
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00685  Apoptotic machinery
     K02084  APAF1; apoptotic protease-activating factor
BRITE hierarchy
Genes
HSA: 317(APAF1)
PTR: 452153(APAF1)
PPS: 100995524(APAF1)
GGO: 101135722(APAF1)
PON: 100459074(APAF1)
NLE: 100590369(APAF1)
MCC: 694164(APAF1)
MCF: 102137473(APAF1)
CSAB: 103238923(APAF1)
RRO: 104656342(APAF1)
RBB: 108543462(APAF1)
CJC: 100400521 100403825(APAF1)
SBQ: 101048222(APAF1)
MMU: 11783(Apaf1)
RNO: 78963(Apaf1)
CGE: 100758500(Apaf1)
NGI: 103733246(Apaf1)
HGL: 101706721(Apaf1)
CCAN: 109690039(Apaf1)
OCU: 103348383(APAF1)
TUP: 102476798(APAF1)
CFA: 482620(APAF1)
AML: 100464163(APAF1)
UMR: 103660136(APAF1)
ORO: 101383104(APAF1)
FCA: 768257(APAF1)
PTG: 102964536(APAF1)
AJU: 106973746(APAF1)
BTA: 537782(APAF1)
BOM: 102285660(APAF1)
BIU: 109559418(APAF1)
PHD: 102326029 102326324(APAF1)
CHX: 102188830(APAF1)
OAS: 100135699(APAF1)
SSC: 100513283(APAF1)
CFR: 102516966(APAF1)
CDK: 105097442(APAF1)
BACU: 103006029(APAF1)
LVE: 103069785(APAF1)
OOR: 101280303(APAF1)
ECB: 100052552(APAF1)
EPZ: 103550811(APAF1)
EAI: 106827252(APAF1)
MYB: 102242936(APAF1)
MYD: 102773861(APAF1)
HAI: 109382336(APAF1)
RSS: 109447611(APAF1)
PALE: 102897687(APAF1)
LAV: 100665091(APAF1)
TMU: 101349393
MDO: 100013051(APAF1)
SHR: 100932636(APAF1)
OAA: 100073402(APAF1)
GGA: 417926(APAF1)
MGP: 100549497(APAF1)
CJO: 107311930(APAF1)
APLA: 101799443(APAF1)
ACYG: 106036949(APAF1)
TGU: 100222477(APAF1)
GFR: 102039129(APAF1)
FAB: 101817511(APAF1)
PHI: 102103178(APAF1)
PMAJ: 107204470(APAF1)
CCW: 104696424(APAF1)
FPG: 101911538(APAF1)
FCH: 102046505(APAF1)
CLV: 102095228(APAF1)
EGZ: 104132316(APAF1)
AAM: 106488625(APAF1)
ASN: 102371819(APAF1)
AMJ: 102560580(APAF1)
PSS: 102451576(APAF1)
CMY: 102940699(APAF1)
CPIC: 101942057(APAF1)
ACS: 100556318(apaf1)
PVT: 110084192(APAF1)
PBI: 103057709(APAF1)
GJA: 107118861(APAF1)
XLA: 444261(apaf1.L)
XTR: 100127738(apaf1)
NPR: 108798110(APAF1)
DRE: 58131(apaf1)
SRX: 107725574(apaf1) 107744928
SANH: 107664840 107695885(apaf1)
IPU: 108274767(apaf1)
AMEX: 103032437(apaf1)
TRU: 101076369(apaf1)
LCO: 104925081(apaf1)
NCC: 104967722(apaf1)
MZE: 101470098(apaf1)
OLA: 101158654(apaf1)
XMA: 102220895(apaf1)
PRET: 103459197(apaf1)
NFU: 107373731 107385893(apaf1)
CSEM: 103382677(apaf1)
LCF: 108889265(apaf1)
HCQ: 109523695(apaf1)
BPEC: 110161643(apaf1)
ELS: 105020401(apaf1)
SFM: 108931524(apaf1)
LCM: 102354670(APAF1)
CMK: 103187971(apaf1)
APLC: 110975466
SKO: 102804745
DME: Dmel_CG6829(Dark)
DSI: Dsimw501_GD11239(Dsim_GD11239)
MDE: 101889170
AAG: 5567237
AME: 100578356
BIM: 100748962
BTER: 100651239
SOC: 105193154
AEC: 105154033
ACEP: 105617990
PBAR: 105432976
HST: 105183168
CFO: 105257852
LHU: 105672289
PGC: 109852961
NVI: 100679184
TCA: 662893
NVL: 108557857
BMOR: 100529085(Apaf-1)
PMAC: 106711546
PRAP: 110999308
PXY: 105383941
API: 100571592
DNX: 107164576
ZNE: 110839034
FCD: 110858562
TSP: Tsp_01495
ADF: 107354394
HMG: 100210403(APAF-1)
AQU: 105313814
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9267021
  Authors
Zou H, Henzel WJ, Liu X, Lutschg A, Wang X
  Title
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.
  Journal
Cell 90:405-13 (1997)
DOI:10.1016/S0092-8674(00)80501-2
  Sequence
[hsa:317]
Reference
  Authors
Hara H, Takeda A, Takeuchi M, Wakeham AC, Itie A, Sasaki M, Mak TW, Yoshimura A, Nomoto K, Yoshida H
  Title
The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.
  Journal
J Immunol 168:2288-95 (2002)
DOI:10.4049/jimmunol.168.5.2288
  Sequence
[mmu:11783]

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