KEGG   ORTHOLOGY: K02085Help
Entry
K02085                      KO                                     

Name
APC
Definition
adenomatosis polyposis coli protein
Pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Colorectal cancer
Endometrial cancer
Basal cell carcinoma
Disease
H00017  
Esophageal cancer
H00018  
Gastric cancer
H00020  
Colorectal cancer
H00044  
Cancer of the anal canal
H00047  
Gallbladder cancer
H01025  
Familial adenomatous polyposis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K02085  APC; adenomatosis polyposis coli protein
   04390 Hippo signaling pathway
    K02085  APC; adenomatosis polyposis coli protein
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K02085  APC; adenomatosis polyposis coli protein
  Cellular commiunity
   04550 Signaling pathways regulating pluripotency of stem cells
    K02085  APC; adenomatosis polyposis coli protein
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02085  APC; adenomatosis polyposis coli protein
   05206 MicroRNAs in cancer
    K02085  APC; adenomatosis polyposis coli protein
   05210 Colorectal cancer
    K02085  APC; adenomatosis polyposis coli protein
   05217 Basal cell carcinoma
    K02085  APC; adenomatosis polyposis coli protein
   05213 Endometrial cancer
    K02085  APC; adenomatosis polyposis coli protein
  Infectious diseases
   05166 HTLV-I infection
    K02085  APC; adenomatosis polyposis coli protein
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02085  APC; adenomatosis polyposis coli protein
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Other centrosome associated proteins
    K02085  APC; adenomatosis polyposis coli protein
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    APC
     K02085  APC; adenomatosis polyposis coli protein
BRITE hierarchy
Genes
HSA: 
10297(APC2) 324(APC)
PTR: 
455551(APC2) 461999(APC)
PPS: 
100977146(APC2) 100992823(APC)
GGO: 
101130129(APC2) 101137098(APC)
PON: 
100431482(APC) 100435472(APC2)
MCC: 
693443(APC) 707345(APC2)
MCF: 
102123489(APC2) 102126553(APC)
MMU: 
11789(Apc) 23805(Apc2)
RNO: 
24205(Apc) 299611(Apc2)
CGE: 
100750563(Apc) 100767273(Apc2)
HGL: 
101699189(Apc2) 101704055(Apc)
TUP: 
102470052(APC2) 102484859(APC)
CFA: 
479139(APC) 485084(APC2)
AML: 
FCA: 
101096138(APC) 101097211(APC2)
PTG: 
BTA: 
526572(APC2) 533233(APC)
BOM: 
102272116(APC) 102282143(APC2)
PHD: 
102316874(APC) 102326036(APC2)
CHX: 
102177435(APC2) 102184724(APC)
OAS: 
101104664(APC) 101115458(APC2)
SSC: 
100517932(APC) 100579172(APC2)
CFR: 
102521446(APC2) 102522612(APC)
BACU: 
103001169(APC) 103014178(APC2)
LVE: 
103083467(APC) 103084983(APC2)
ECB: 
MYB: 
102243742(APC2) 102246124(APC)
MYD: 
102751934(APC) 102768246(APC2)
PALE: 
102880260(APC) 102891886(APC2)
MDO: 
100013592(APC) 100020785(APC2)
SHR: 
OAA: 
GGA: 
415607(APC) 429363(APC2)
APLA: 
TGU: 
FAB: 
101819406(APC) 101820774(APC2)
PHI: 
102099173(APC) 102111044(APC2)
FPG: 
101912417(APC2) 101913625(APC)
FCH: 
102051031(APC) 102052505(APC2)
CLV: 
102093207(APC) 102094189(APC2)
ASN: 
102376341(APC2) 102377654(APC)
AMJ: 
102567239(APC) 102570878(APC2)
PSS: 
102462387(APC) 102463006(APC2)
CMY: 
102943104(APC) 102947058(APC2)
ACS: 
100559625(apc2) 100561377(apc)
PBI: 
103062549(APC) 103068257(APC2)
XLA: 
399455(apc)
XTR: 
100487473(apc2) 779466(apc)
DRE: 
386762(apc) 565771(apc2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103181147(apc) 103182088(apc2)
BFO: 
CIN: 
778909(apc)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
CQU: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
TSP: 
SMM: 
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Nathke IS
  Title
A role for the Adenomatous Polyposis Coli protein in chromosome segregation.
  Journal
Nat Cell Biol 3:429-32 (2001)
Reference
  Authors
van Es JH, Kirkpatrick C, van de Wetering M, Molenaar M, Miles A, Kuipers J, Destree O, Peifer M, Clevers H
  Title
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
  Journal
Curr Biol 9:105-8 (1999)
  Sequence
[hsa:10297]
Reference
  Authors
Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O, Akiyama T
  Title
Asef, a link between the tumor suppressor APC and G-protein signaling.
  Journal
Science 289:1194-7 (2000)
  Sequence
[hsa:324]

DBGET integrated database retrieval system