KEGG   ORTHOLOGY: K02159Help
Entry
K02159                      KO                                     

Name
BAX
Definition
apoptosis regulator BAX
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
Sphingolipid signaling pathway
p53 signaling pathway
Protein processing in endoplasmic reticulum
Apoptosis
Longevity regulating pathway
Apoptosis - multiple species
Neurotrophin signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Prion diseases
Tuberculosis
Hepatitis B
HTLV-I infection
Pathways in cancer
Viral carcinogenesis
Colorectal cancer
Disease
H00020  
Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K02159  BAX; apoptosis regulator BAX
 Environmental Information Processing
  Signal transduction
   04071 Sphingolipid signaling pathway
    K02159  BAX; apoptosis regulator BAX
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02159  BAX; apoptosis regulator BAX
   04215 Apoptosis - multiple species
    K02159  BAX; apoptosis regulator BAX
   04115 p53 signaling pathway
    K02159  BAX; apoptosis regulator BAX
 Organismal Systems
  Nervous system
   04722 Neurotrophin signaling pathway
    K02159  BAX; apoptosis regulator BAX
  Aging
   04211 Longevity regulating pathway - mammal
    K02159  BAX; apoptosis regulator BAX
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02159  BAX; apoptosis regulator BAX
   05203 Viral carcinogenesis
    K02159  BAX; apoptosis regulator BAX
   05210 Colorectal cancer
    K02159  BAX; apoptosis regulator BAX
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K02159  BAX; apoptosis regulator BAX
   05016 Huntington's disease
    K02159  BAX; apoptosis regulator BAX
   05020 Prion diseases
    K02159  BAX; apoptosis regulator BAX
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K02159  BAX; apoptosis regulator BAX
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02159  BAX; apoptosis regulator BAX
  Infectious diseases
   05152 Tuberculosis
    K02159  BAX; apoptosis regulator BAX
   05166 HTLV-I infection
    K02159  BAX; apoptosis regulator BAX
   05161 Hepatitis B
    K02159  BAX; apoptosis regulator BAX
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K02159  BAX; apoptosis regulator BAX
   01522 Endocrine resistance
    K02159  BAX; apoptosis regulator BAX
   01524 Platinum drug resistance
    K02159  BAX; apoptosis regulator BAX
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    K02159  BAX; apoptosis regulator BAX
Transporters [BR:ko02000]
 Other Transporters
  Pores ion channels
   K02159  BAX; apoptosis regulator BAX
BRITE hierarchy
Other DBs
Genes
HSA: 
581(BAX)
PTR: 
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
718948(BAX)
MCF: 
CSAB: 
RRO: 
CJC: 
SBQ: 
MMU: 
12028(Bax)
RNO: 
24887(Bax)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
403523(BAX)
AML: 
UMR: 
FCA: 
493837(BAX)
PTG: 
BTA: 
280730(BAX)
BOM: 
PHD: 
CHX: 
OAS: 
443059(BAX)
SSC: 
396633(BAX)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
LAV: 
MDO: 
TGU: 
PHI: 
FPG: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
GJA: 
XLA: 
373637(bax.L)
XTR: 
394793(bax)
DRE: 
100004321 58081(baxa) 767645(im:7148473)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
CIN: 
SPU: 
SKO: 
DPX: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8358790
  Authors
Oltvai ZN, Milliman CL, Korsmeyer SJ
  Title
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
  Journal
Cell 74:609-19 (1993)
  Sequence
[hsa:581]
Reference
  Authors
Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ
  Title
Proapoptotic BAX and BAK control multiple initiator caspases.
  Journal
EMBO Rep 6:379-85 (2005)
Reference
  Authors
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD
  Title
BAX activation is initiated at a novel interaction site.
  Journal
Nature 455:1076-81 (2008)
  Sequence
[hsa:581]

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