KEGG   ORTHOLOGY: K02161Help
Entry
K02161                      KO                                     

Name
BCL2
Definition
apoptosis regulator Bcl-2
Pathway
EGFR tyrosine kinase inhibitor resistance
NF-kappa B signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
PI3K-Akt signaling pathway
Apoptosis
Apoptosis - multiple species
Adrenergic signaling in cardiomyocytes
Hedgehog signaling pathway
Focal adhesion
Jak-STAT signaling pathway
Neurotrophin signaling pathway
Cholinergic synapse
AGE-RAGE signaling pathway in diabetic complications
Amyotrophic lateral sclerosis (ALS)
Toxoplasmosis
Tuberculosis
Hepatitis B
Epstein-Barr virus infection
Pathways in cancer
MicroRNAs in cancer
Colorectal cancer
Prostate cancer
Small cell lung cancer
Disease
H00005  
Chronic lymphocytic leukemia (CLL)
H00013  
Small cell lung cancer
H00018  
Gastric cancer
H00028  
Choriocarcinoma
H00030  
Cervical cancer
H00041  
Kaposi's sarcoma
H00054  
Nasopharyngeal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K02161  BCL2; apoptosis regulator Bcl-2
 Environmental Information Processing
  Signal transduction
   04340 Hedgehog signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04630 Jak-STAT signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04064 NF-kappa B signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04066 HIF-1 signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04071 Sphingolipid signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04151 PI3K-Akt signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02161  BCL2; apoptosis regulator Bcl-2
   04215 Apoptosis - multiple species
    K02161  BCL2; apoptosis regulator Bcl-2
  Cellular commiunity
   04510 Focal adhesion
    K02161  BCL2; apoptosis regulator Bcl-2
 Organismal Systems
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K02161  BCL2; apoptosis regulator Bcl-2
  Nervous system
   04725 Cholinergic synapse
    K02161  BCL2; apoptosis regulator Bcl-2
   04722 Neurotrophin signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05206 MicroRNAs in cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05210 Colorectal cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05215 Prostate cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05222 Small cell lung cancer
    K02161  BCL2; apoptosis regulator Bcl-2
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K02161  BCL2; apoptosis regulator Bcl-2
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02161  BCL2; apoptosis regulator Bcl-2
  Infectious diseases
   05152 Tuberculosis
    K02161  BCL2; apoptosis regulator Bcl-2
   05161 Hepatitis B
    K02161  BCL2; apoptosis regulator Bcl-2
   05169 Epstein-Barr virus infection
    K02161  BCL2; apoptosis regulator Bcl-2
   05145 Toxoplasmosis
    K02161  BCL2; apoptosis regulator Bcl-2
  Antineoplastic resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K02161  BCL2; apoptosis regulator Bcl-2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02161  BCL2; apoptosis regulator Bcl-2
BRITE hierarchy
Genes
HSA: 
596(BCL2)
PTR: 
738409(BCL2)
PPS: 
100992951(BCL2)
GGO: 
101136123(BCL2)
PON: 
100938429(BCL2)
NLE: 
100599011(BCL2)
MCC: 
707407(BCL2)
MCF: 
102138212(BCL2)
RRO: 
104682248(BCL2)
CJC: 
100408947(BCL2)
MMU: 
12043(Bcl2)
RNO: 
24224(Bcl2)
CGE: 
100774873(Bcl2)
NGI: 
103740099(Bcl2)
HGL: 
101701667(Bcl2)
OCU: 
100359045(BCL2)
TUP: 
102474592(BCL2)
CFA: 
403416(BCL2)
AML: 
100484344(BCL2)
UMR: 
103676164(BCL2)
FCA: 
493934(BCL2)
PTG: 
102953487(BCL2)
BTA: 
281020(BCL2)
BOM: 
102268592(BCL2)
PHD: 
102336438(BCL2)
CHX: 
100861254(BCL2)
OAS: 
101119602(BCL2)
SSC: 
100049703(BCL2)
CFR: 
102523830(BCL2)
BACU: 
103015542(BCL2)
LVE: 
103077294(BCL2)
ECB: 
100050934(BCL2)
MYB: 
102248597(BCL2)
MYD: 
102769473(BCL2)
PALE: 
102896443(BCL2)
MDO: 
100016570(BCL2)
SHR: 
100934666(BCL2)
GGA: 
396282(BCL2)
MGP: 
100545008(BCL2)
APLA: 
101791240(BCL2)
TGU: 
100224888(BCL2)
GFR: 
102032008(BCL2)
FAB: 
101818228(BCL2)
PHI: 
102113262(BCL2)
CCW: 
104698161(BCL2)
FPG: 
101921728(BCL2)
FCH: 
102056589(BCL2)
CLV: 
102092853(BCL2)
ASN: 
102370035(BCL2)
AMJ: 
102564752(BCL2)
PSS: 
102444136(BCL2)
CMY: 
102941395(BCL2)
ACS: 
100564886(bcl2)
PBI: 
103059077(BCL2)
XLA: 
100271914(bcl2)
XTR: 
100485267(bcl2)
DRE: 
100007048(bcl2b) 570772(bcl2a)
TRU: 
101071405(bcl2)
MZE: 
OLA: 
101163032(bcl2)
XMA: 
102223266(bcl2)
CMK: 
103183201(bcl2)
ISC: 
AQU: 
VG: 
26836919(vBcl-2)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
PMID:3523487
  Authors
Tsujimoto Y, Croce CM
  Title
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
  Journal
Proc Natl Acad Sci U S A 83:5214-8 (1986)
  Sequence
[hsa:596]
Reference
  Authors
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B
  Title
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.
  Journal
Mol Cell 30:678-88 (2008)
  Sequence
[hsa:596]

DBGET integrated database retrieval system