KEGG   ORTHOLOGY: K02187Help
Entry
K02187                      KO                                     

Name
CASP3
Definition
caspase 3 [EC:3.4.22.56]
Pathway
Platinum drug resistance
MAPK signaling pathway
p53 signaling pathway
Apoptosis
Apoptosis - multiple species
Natural killer cell mediated cytotoxicity
IL-17 signaling pathway
TNF signaling pathway
Serotonergic synapse
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Alzheimer's disease
Parkinson's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Epithelial cell signaling in Helicobacter pylori infection
Pertussis
Legionellosis
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Herpes simplex infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Small cell lung cancer
Viral myocarditis
Module
M00685  
Apoptotic machinery
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K02187  CASP3; caspase 3
   04668 TNF signaling pathway
    K02187  CASP3; caspase 3
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02187  CASP3; caspase 3
   04215 Apoptosis - multiple species
    K02187  CASP3; caspase 3
   04115 p53 signaling pathway
    K02187  CASP3; caspase 3
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K02187  CASP3; caspase 3
   04657 IL-17 signaling pathway
    K02187  CASP3; caspase 3
  Nervous system
   04726 Serotonergic synapse
    K02187  CASP3; caspase 3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02187  CASP3; caspase 3
   05206 MicroRNAs in cancer
    K02187  CASP3; caspase 3
   05205 Proteoglycans in cancer
    K02187  CASP3; caspase 3
   05203 Viral carcinogenesis
    K02187  CASP3; caspase 3
   05210 Colorectal cancer
    K02187  CASP3; caspase 3
   05222 Small cell lung cancer
    K02187  CASP3; caspase 3
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K02187  CASP3; caspase 3
   05012 Parkinson's disease
    K02187  CASP3; caspase 3
   05014 Amyotrophic lateral sclerosis (ALS)
    K02187  CASP3; caspase 3
   05016 Huntington's disease
    K02187  CASP3; caspase 3
  Cardiovascular diseases
   05416 Viral myocarditis
    K02187  CASP3; caspase 3
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K02187  CASP3; caspase 3
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02187  CASP3; caspase 3
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02187  CASP3; caspase 3
   05133 Pertussis
    K02187  CASP3; caspase 3
   05134 Legionellosis
    K02187  CASP3; caspase 3
   05152 Tuberculosis
    K02187  CASP3; caspase 3
   05161 Hepatitis B
    K02187  CASP3; caspase 3
   05168 Herpes simplex infection
    K02187  CASP3; caspase 3
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K02187  CASP3; caspase 3
   05165 Human papillomavirus infection
    K02187  CASP3; caspase 3
   05146 Amoebiasis
    K02187  CASP3; caspase 3
   05145 Toxoplasmosis
    K02187  CASP3; caspase 3
  Drug resistance
   01524 Platinum drug resistance
    K02187  CASP3; caspase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00685  Apoptotic machinery
     K02187  CASP3; caspase 3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.56  caspase-3
     K02187  CASP3; caspase 3
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K02187  CASP3; caspase 3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
836(CASP3)
PTR: 
461669(CASP3)
PPS: 
100974934(CASP3)
GGO: 
101126742(CASP3)
PON: 
100435491(CASP3)
NLE: 
100585064(CASP3)
MCC: 
694473(CASP3)
MCF: 
102144182(CASP3)
CSAB: 
103236614(CASP3)
RRO: 
RBB: 
CJC: 
100387570(CASP3)
SBQ: 
101029697(CASP3)
MMU: 
12367(Casp3)
RNO: 
25402(Casp3)
CGE: 
100689061(Casp3)
NGI: 
HGL: 
CCAN: 
OCU: 
100008840(CASP3)
TUP: 
CFA: 
403567(CASP3)
AML: 
100469056(CASP3)
UMR: 
103680991(CASP3)
ORO: 
101371336(CASP3)
FCA: 
493932(CASP3)
PTG: 
102954729(CASP3)
AJU: 
106979326(CASP3)
BTA: 
408016(CASP3)
BOM: 
102287348(CASP3)
BIU: 
109553316(CASP3)
PHD: 
102334771(CASP3)
CHX: 
102177031(CASP3)
OAS: 
443031(CASP3)
SSC: 
397244(CASP3)
CFR: 
102520133(CASP3)
CDK: 
105084433(CASP3)
BACU: 
103019939(CASP3)
LVE: 
103073819(CASP3)
ECB: 
100034083(CASP3)
EPZ: 
103549132(CASP3)
EAI: 
106830081(CASP3)
MYB: 
102258599(CASP3)
MYD: 
102760961(CASP3)
HAI: 
109395706(CASP3)
RSS: 
109449637(CASP3)
PALE: 
102897289(CASP3)
LAV: 
100672256(CASP3)
TMU: 
MDO: 
654273(CASP3) 654275
SHR: 
OAA: 
100087105(CASP3)
GGA: 
395476(CASP3)
MGP: 
100548182(CASP3)
CJO: 
107313280(CASP3)
APLA: 
101805296(CASP3)
ACYG: 
106035172(CASP3)
TGU: 
GFR: 
102035830(CASP3)
FAB: 
101808212(CASP3)
PHI: 
102104322(CASP3)
PMAJ: 
107203069(CASP3)
CCW: 
104690575(CASP3)
FPG: 
101913355(CASP3)
FCH: 
102056397(CASP3)
CLV: 
102089427(CASP3)
EGZ: 
104129473(CASP3)
AAM: 
106484082(CASP3)
ASN: 
102383553(CASP3)
AMJ: 
102572621(CASP3) 102576234(CASP14)
PSS: 
102463828(CASP3)
CMY: 
102942062(CASP3)
CPIC: 
101948246(CASP3)
ACS: 
100563931(casp3)
PVT: 
110083865(CASP3)
PBI: 
103049711(CASP3)
GJA: 
107115654(CASP3)
XLA: 
100036910(casp3.L) 397720(casp3.S)
XTR: 
100151728(casp3)
NPR: 
DRE: 
140621(casp3a) 566604(casp3b)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
TRU: 
446083(casp3)
TNG: 
LCO: 
104928227 104936945(caspase-3)
NCC: 
MZE: 
OLA: 
XMA: 
PRET: 
NFU: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
105006735(casp3) 105029385(casp3)
SFM: 
108924572(casp3)
LCM: 
106705928(CASP3)
CMK: 
103187405(casp3)
BFO: 
SKO: 
DPX: 
ISC: 
NAI: 
HRO: 
LGI: 
CRG: 
MYI: 
SMM: 
SHX: 
OVI: 
NVE: 
EPA: 
ADF: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7983002
  Authors
Fernandes-Alnemri T, Litwack G, Alnemri ES
  Title
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
  Journal
J Biol Chem 269:30761-4 (1994)
  Sequence
[hsa:836]
Reference
  Authors
Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH
  Title
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.
  Journal
BMC Cell Biol 14:32 (2013)
DOI:10.1186/1471-2121-14-32
  Sequence
[mmu:12367]

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