KEGG   ORTHOLOGY: K02187Help
Entry
K02187                      KO                                     

Name
CASP3
Definition
caspase 3 [EC:3.4.22.56]
Pathway
Platinum drug resistance
MAPK signaling pathway
p53 signaling pathway
Apoptosis
Apoptosis - multiple species
Natural killer cell mediated cytotoxicity
TNF signaling pathway
Serotonergic synapse
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Alzheimer's disease
Parkinson's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Epithelial cell signaling in Helicobacter pylori infection
Pertussis
Legionellosis
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Herpes simplex infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Viral myocarditis
Module
M00685  
Apoptotic machinery
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K02187  CASP3; caspase 3
   04668 TNF signaling pathway
    K02187  CASP3; caspase 3
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02187  CASP3; caspase 3
   04215 Apoptosis - multiple species
    K02187  CASP3; caspase 3
   04115 p53 signaling pathway
    K02187  CASP3; caspase 3
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K02187  CASP3; caspase 3
  Nervous system
   04726 Serotonergic synapse
    K02187  CASP3; caspase 3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02187  CASP3; caspase 3
   05206 MicroRNAs in cancer
    K02187  CASP3; caspase 3
   05205 Proteoglycans in cancer
    K02187  CASP3; caspase 3
   05203 Viral carcinogenesis
    K02187  CASP3; caspase 3
   05210 Colorectal cancer
    K02187  CASP3; caspase 3
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K02187  CASP3; caspase 3
   05012 Parkinson's disease
    K02187  CASP3; caspase 3
   05014 Amyotrophic lateral sclerosis (ALS)
    K02187  CASP3; caspase 3
   05016 Huntington's disease
    K02187  CASP3; caspase 3
  Cardiovascular diseases
   05416 Viral myocarditis
    K02187  CASP3; caspase 3
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K02187  CASP3; caspase 3
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02187  CASP3; caspase 3
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02187  CASP3; caspase 3
   05133 Pertussis
    K02187  CASP3; caspase 3
   05134 Legionellosis
    K02187  CASP3; caspase 3
   05152 Tuberculosis
    K02187  CASP3; caspase 3
   05161 Hepatitis B
    K02187  CASP3; caspase 3
   05168 Herpes simplex infection
    K02187  CASP3; caspase 3
   05146 Amoebiasis
    K02187  CASP3; caspase 3
   05145 Toxoplasmosis
    K02187  CASP3; caspase 3
  Antineoplastic resistance
   01524 Platinum drug resistance
    K02187  CASP3; caspase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00685  Apoptotic machinery
     K02187  CASP3; caspase 3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.56  caspase-3
     K02187  CASP3; caspase 3
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K02187  CASP3; caspase 3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
836(CASP3)
PTR: 
461669(CASP3)
PPS: 
100974934(CASP3)
GGO: 
101126742(CASP3)
PON: 
100435491(CASP3)
NLE: 
100585064(CASP3)
MCC: 
694473(CASP3)
MCF: 
102144182(CASP3)
RRO: 
CJC: 
100387570(CASP3)
MMU: 
12367(Casp3)
RNO: 
25402(Casp3)
CGE: 
100689061(Casp3)
NGI: 
103750475(Casp3)
HGL: 
OCU: 
100008840(CASP3)
TUP: 
CFA: 
403567(CASP3)
AML: 
100469056(CASP3)
UMR: 
103680991(CASP3)
FCA: 
493932(CASP3)
PTG: 
102954729(CASP3)
BTA: 
408016(CASP3)
BOM: 
102287348(CASP3)
PHD: 
102334771(CASP3)
CHX: 
102177031(CASP3)
OAS: 
443031(CASP3)
SSC: 
397244(CASP3)
CFR: 
102520133(CASP3)
BACU: 
103019939(CASP3)
LVE: 
103073819(CASP3)
ECB: 
100034083(CASP3)
MYB: 
102258599(CASP3)
MYD: 
102760961(CASP3)
PALE: 
102897289(CASP3)
MDO: 
654273(CASP3) 654275
SHR: 
OAA: 
100087105(CASP3)
GGA: 
395476(CASP3)
MGP: 
100548182(CASP3)
CJO: 
107313280(CASP3)
APLA: 
101805296(CASP3)
TGU: 
GFR: 
102035830(CASP3)
FAB: 
101808212(CASP3)
PHI: 
102104322(CASP3)
CCW: 
104690575(CASP3)
FPG: 
101913355(CASP3)
FCH: 
102056397(CASP3)
CLV: 
102089427(CASP3)
AAM: 
106484082(CASP3)
ASN: 
102383553(CASP3)
AMJ: 
102572621(CASP3)
PSS: 
102463828(CASP3)
CMY: 
102942062(CASP3)
ACS: 
PBI: 
103049711(CASP3)
GJA: 
107115654(CASP3)
XLA: 
XTR: 
100151728(casp3)
DRE: 
140621(casp3a) 566604(casp3b)
TRU: 
446083(casp3)
MZE: 
OLA: 
XMA: 
LCM: 
106705928(CASP3)
CMK: 
103187405(casp3)
MDE: 
ISC: 
HRO: 
LGI: 
SMM: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7983002
  Authors
Fernandes-Alnemri T, Litwack G, Alnemri ES
  Title
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
  Journal
J Biol Chem 269:30761-4 (1994)
  Sequence
[hsa:836]
Reference
  Authors
Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH
  Title
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.
  Journal
BMC Cell Biol 14:32 (2013)
  Sequence
[mmu:12367]

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