KEGG   ORTHOLOGY: K02206Help
Entry
K02206                      KO                                     
Name
CDK2
Definition
cyclin-dependent kinase 2 [EC:2.7.11.22]
Pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Progesterone-mediated oocyte maturation
Hepatitis B
Measles
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Prostate cancer
Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K02206  CDK2; cyclin-dependent kinase 2
   04114 Oocyte meiosis
    K02206  CDK2; cyclin-dependent kinase 2
   04115 p53 signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
 Organismal Systems
  Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K02206  CDK2; cyclin-dependent kinase 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05203 Viral carcinogenesis
    K02206  CDK2; cyclin-dependent kinase 2
   05215 Prostate cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05222 Small cell lung cancer
    K02206  CDK2; cyclin-dependent kinase 2
  Infectious diseases
   05162 Measles
    K02206  CDK2; cyclin-dependent kinase 2
   05161 Hepatitis B
    K02206  CDK2; cyclin-dependent kinase 2
   05168 Herpes simplex infection
    K02206  CDK2; cyclin-dependent kinase 2
   05169 Epstein-Barr virus infection
    K02206  CDK2; cyclin-dependent kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02206  CDK2; cyclin-dependent kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: CMGC group
  CDK family
   K02206  CDK2; cyclin-dependent kinase 2
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    K02206  CDK2; cyclin-dependent kinase 2
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Kinases and associated factors
    K02206  CDK2; cyclin-dependent kinase 2
BRITE hierarchy
Other DBs
COG: 
GO: 
Genes
HSA: 
1017(CDK2)
PTR: 
467032(CDK2)
PPS: 
100981695(CDK2)
GGO: 
101134769(CDK2)
PON: 
100446748(CDK2)
MCC: 
711002(CDK2)
MMU: 
12566(Cdk2)
RNO: 
362817(Cdk2)
CFA: 
AML: 
FCA: 
101093368(CDK2)
BTA: 
519217(CDK2)
SSC: 
100154715
ECB: 
100051790
GGA: 
100529062(CDK2)
ACS: 
100555545
XLA: 
399314(cdk2) 432036
XTR: 
493498(cdk2)
DRE: 
406715(cdk2)
TRU: 
101062041
OLA: 
101161880
SPU: 
585950
DME: 
Dmel_CG10498(cdc2c)
DPO: 
Dpse_GA10356
DAN: 
Dana_GF16690
DER: 
Dere_GG24088
DPE: 
Dper_GL27348
DSE: 
Dsec_GM23132
DSI: 
Dsim_GD19371
DWI: 
Dwil_GK22466
DYA: 
Dyak_GE25682(Dyak_cdc2c)
DGR: 
Dgri_GH17244
DMO: 
Dmoj_GI10591
AGA: 
AgaP_AGAP004579
AAG: 
AaeL_AAEL012339 AaeL_AAEL013329
CQU: 
CpipJ_CPIJ011080
AME: 
409959(cdc2c)
NVI: 
100117828(Cdk2)
API: 
100162479
PHU: 
Phum_PHUM190130
ISC: 
IscW_ISCW019950
NVE: 
NEMVE_v1g185545
HMG: 
100212745
TAD: 
TRIADDRAFT_50896
AQU: 
100641341
ATH: 
AT3G48750(CDC2)
ALY: 
ARALYDRAFT_485229
GMX: 
100127418 100780359 100782865
MTR: 
MTR_119s0025
CSV: 
101217311
RCU: 
RCOM_0973700
POP: 
POPTR_648419(PtrCDKA-1)
VVI: 
100262312
OSA: 
4328135 4331415
DOSA: 
Os02t0123100-01(Os02g0123100)
BDI: 
100821247 100829615
SBI: 
SORBI_04g001920(SORBIDRAFT_04g001920)
ZMA: 
100284730(pco133105a) 542270(cdc2)
SMO: 
SELMODRAFT_139306(CDKA-1) SELMODRAFT_271676(CDKA-2)
PPP: 
PHYPADRAFT_171224
CRE: 
CHLREDRAFT_127285(CDKA1)
VCN: 
VOLCADRAFT_127504(cdka1)
OLU: 
OSTLU_49332
OTA: 
Ot04g00130(CDK-A)
ECU: 
ECU08_1920
NCE: 
NCER_100587
NGR: 
NAEGRDRAFT_60904
DDI: 
DDB_G0272813(cdk1)
DPP: 
DICPUDRAFT_41903
EHI: 
EHI_065280(119.t00008) EHI_152430(6.t00087) EHI_153140(13.t00001)
EDI: 
EDI_007830 EDI_093320 EDI_169580
CPV: 
cgd1_60
CHO: 
Chro.10015
TCR: 
506677.20
GLA: 
GL50803_8037
TVA: 
TVAG_225330 TVAG_453900
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tanaka S, Tak YS, Araki H
  Title
The role of CDK in the initiation step of DNA replication in eukaryotes.
  Journal
Cell Div 2:16 (2007)
Reference
  Authors
Jeon Y, Lee KY, Ko MJ, Lee YS, Kang S, Hwang DS
  Title
Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition.
  Journal
J Biol Chem 282:14882-90 (2007)
Reference
  Authors
Zhao H, Chen X, Gurian-West M, Roberts JM
  Title
Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.
  Journal
Mol Cell Biol 32:1421-32 (2012)
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