KEGG   ORTHOLOGY: K02206Help
Entry
K02206                      KO                                     

Name
CDK2
Definition
cyclin-dependent kinase 2 [EC:2.7.11.22]
Pathway
FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Progesterone-mediated oocyte maturation
Hepatitis B
Measles
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Prostate cancer
Small cell lung cancer
Module
M00692  
Cell cycle - G1/S transition
M00693  
Cell cycle - G2/M transition
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
   04151 PI3K-Akt signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K02206  CDK2; cyclin-dependent kinase 2
   04114 Oocyte meiosis
    K02206  CDK2; cyclin-dependent kinase 2
   04115 p53 signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
 Organismal Systems
  Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K02206  CDK2; cyclin-dependent kinase 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05203 Viral carcinogenesis
    K02206  CDK2; cyclin-dependent kinase 2
   05215 Prostate cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05222 Small cell lung cancer
    K02206  CDK2; cyclin-dependent kinase 2
  Infectious diseases
   05162 Measles
    K02206  CDK2; cyclin-dependent kinase 2
   05161 Hepatitis B
    K02206  CDK2; cyclin-dependent kinase 2
   05168 Herpes simplex infection
    K02206  CDK2; cyclin-dependent kinase 2
   05169 Epstein-Barr virus infection
    K02206  CDK2; cyclin-dependent kinase 2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00692  Cell cycle - G1/S transition
     K02206  CDK2; cyclin-dependent kinase 2
    M00693  Cell cycle - G2/M transition
     K02206  CDK2; cyclin-dependent kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02206  CDK2; cyclin-dependent kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: CMGC group
  CDK family
   K02206  CDK2; cyclin-dependent kinase 2
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    K02206  CDK2; cyclin-dependent kinase 2
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Kinases and associated factors
    K02206  CDK2; cyclin-dependent kinase 2
BRITE hierarchy
Other DBs
COG: 
GO: 
Genes
HSA: 
1017(CDK2)
PTR: 
467032(CDK2)
PPS: 
100981695(CDK2)
GGO: 
101134769(CDK2)
PON: 
100446748(CDK2)
NLE: 
100592796(CDK2)
MCC: 
711002(CDK2)
MCF: 
102139233(CDK2)
CJC: 
100398703(CDK2)
MMU: 
12566(Cdk2)
RNO: 
362817(Cdk2)
CGE: 
100689039(Cdk2)
NGI: 
103746495(Cdk2)
HGL: 
101725353(Cdk2)
OCU: 
100134865(CDK2)
TUP: 
102500015(CDK2)
CFA: 
100855704(CDK2)
AML: 
UMR: 
103682503(CDK2)
FCA: 
101093368(CDK2)
PTG: 
102959572(CDK2)
BTA: 
519217(CDK2)
BOM: 
102277344(CDK2)
PHD: 
102344511(CDK2)
CHX: 
100860751(CDK2)
OAS: 
SSC: 
CFR: 
102504649(CDK2)
BACU: 
103012976(CDK2)
LVE: 
103089138(CDK2)
ECB: 
100051790(CDK2)
MYB: 
102256122(CDK2)
MYD: 
102756838(CDK2)
PALE: 
102893397(CDK2)
GGA: 
100529062(CDK2)
FAB: 
PHI: 
102108666(CDK2)
ASN: 
102376317(CDK2)
AMJ: 
102570724(CDK2)
PSS: 
102459974(CDK2)
CMY: 
102929928(CDK2)
ACS: 
100555545(cdk2)
PBI: 
103054413(CDK2)
XLA: 
XTR: 
493498(cdk2)
DRE: 
406715(cdk2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE25682(Dyak_cdc2c)
DGR: 
DMO: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409959(cdc2c)
NVI: 
100117828(Cdk2)
TCA: 
BMOR: 
101738936(CDK2)
API: 
ISC: 
LOA: 
HRO: 
LGI: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT3G48750(CDC2)
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
VVI: 
SLY: 
101248452 544139(cdc2A-1) 544140(cdc2A-2)
SOT: 
OSA: 
DOSA: 
Os02t0123100-01(Os02g0123100) Os03t0108800-01(Os03g0108800) Os03t0118400-01(Os03g0118400)
OBR: 
BDI: 
SBI: 
SORBI_01g049350(SORBIDRAFT_01g049350) SORBI_04g001920(SORBIDRAFT_04g001920)
ZMA: 
100273306(gpm167a) 100284730(pco133105a) 103626697 103628436 542270(cdc2)
SITA: 
PDA: 
MUS: 
ATR: 
s00012p00138230(AMTR_s00012p00138230) s00027p00202830(AMTR_s00027p00202830)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
Ot04g00130(CDK-A)
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
GSL: 
CCP: 
ECU: 
EIN: 
EHE: 
ERO: 
DDI: 
DPP: 
DFA: 
DFA_00840(cdk1)
EHI: 
EHI_065280(119.t00008) EHI_152430(6.t00087) EHI_153140(13.t00001)
EDI: 
ACAN: 
PFA: 
PFH: 
PBE: 
CPV: 
CHO: 
PTM: 
PIF: 
PSOJ: 
EHX: 
GTT: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tanaka S, Tak YS, Araki H
  Title
The role of CDK in the initiation step of DNA replication in eukaryotes.
  Journal
Cell Div 2:16 (2007)
Reference
  Authors
Jeon Y, Lee KY, Ko MJ, Lee YS, Kang S, Hwang DS
  Title
Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition.
  Journal
J Biol Chem 282:14882-90 (2007)
Reference
  Authors
Zhao H, Chen X, Gurian-West M, Roberts JM
  Title
Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.
  Journal
Mol Cell Biol 32:1421-32 (2012)

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