KEGG   ORTHOLOGY: K02373Help
Entry
K02373                      KO                                     

Name
FADD
Definition
FAS-associated death domain protein
Pathway
ko01524  Platinum drug resistance
ko04210  Apoptosis
ko04215  Apoptosis - multiple species
ko04217  Necroptosis
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko05010  Alzheimer's disease
ko05142  Chagas disease (American trypanosomiasis)
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05165  Human papillomavirus infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04668 TNF signaling pathway
    K02373  FADD; FAS-associated death domain protein
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02373  FADD; FAS-associated death domain protein
   04215 Apoptosis - multiple species
    K02373  FADD; FAS-associated death domain protein
   04217 Necroptosis
    K02373  FADD; FAS-associated death domain protein
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K02373  FADD; FAS-associated death domain protein
   04624 Toll and Imd signaling pathway
    K02373  FADD; FAS-associated death domain protein
   04621 NOD-like receptor signaling pathway
    K02373  FADD; FAS-associated death domain protein
   04622 RIG-I-like receptor signaling pathway
    K02373  FADD; FAS-associated death domain protein
   04657 IL-17 signaling pathway
    K02373  FADD; FAS-associated death domain protein
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02373  FADD; FAS-associated death domain protein
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K02373  FADD; FAS-associated death domain protein
  Infectious diseases
   05152 Tuberculosis
    K02373  FADD; FAS-associated death domain protein
   05161 Hepatitis B
    K02373  FADD; FAS-associated death domain protein
   05168 Herpes simplex infection
    K02373  FADD; FAS-associated death domain protein
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K02373  FADD; FAS-associated death domain protein
   05165 Human papillomavirus infection
    K02373  FADD; FAS-associated death domain protein
   05142 Chagas disease (American trypanosomiasis)
    K02373  FADD; FAS-associated death domain protein
  Drug resistance
   01524 Platinum drug resistance
    K02373  FADD; FAS-associated death domain protein
BRITE hierarchy
Genes
HSA: 8772(FADD)
PTR: 451389(FADD)
PPS: 100968673(FADD)
GGO: 101134274(FADD)
PON: 100439256(FADD)
NLE: 100607557(FADD)
MCC: 708606(FADD)
MCF: 101866285(FADD)
CSAB: 103245758(FADD)
RRO: 104677132(FADD)
RBB: 108538801(FADD)
CJC: 100410616(FADD)
SBQ: 101046905(FADD)
MMU: 14082(Fadd)
RNO: 266610(Fadd)
CGE: 100774599(Fadd)
NGI: 103751502(Fadd)
HGL: 101709972(Fadd)
CCAN: 109700274(Fadd)
OCU: 103346753(FADD)
TUP: 102489799(FADD)
CFA: 611694(FADD)
AML: 100468003(FADD)
UMR: 103671072(FADD)
ORO: 101385048(FADD)
FCA: 101087871(FADD)
PTG: 102965744(FADD)
AJU: 106982870(FADD)
BTA: 493720(FADD)
BOM: 102271962(FADD)
BIU: 109554562(FADD)
PHD: 102330217(FADD)
CHX: 102170760(FADD)
OAS: 101116783(FADD)
SSC: 595129(FADD)
CFR: 102519266(FADD)
CDK: 105104389(FADD)
BACU: 103014148(FADD)
LVE: 103080339(FADD)
OOR: 101272962(FADD)
ECB: 100061802(FADD)
EPZ: 103566999(FADD)
EAI: 106822168(FADD)
MYD: 102756704(FADD)
HAI: 109389315(FADD)
RSS: 109460354(FADD)
PALE: 102892511(FADD)
LAV: 100662633(FADD)
TMU: 101352734
MDO: 100031941(FADD)
SHR: 100925732(FADD)
OAA: 100075638(FADD)
GGA: 423146(FADD)
MGP: 100540536(FADD)
CJO: 107314471(FADD)
APLA: 101801863(FADD)
ACYG: 106044712(FADD)
TGU: 100229649(FADD)
GFR: 102042362(FADD)
FAB: 101806236(FADD)
PHI: 102102219(FADD)
PMAJ: 107205253(FADD)
CCW: 104697634(FADD)
FPG: 101918701(FADD)
FCH: 102055286(FADD)
CLV: 102085703(FADD)
EGZ: 104124706(FADD)
AAM: 106498371(FADD)
ASN: 102377608(FADD)
AMJ: 102572187(FADD)
PSS: 102448271(FADD)
CMY: 102930159(FADD)
CPIC: 101944927(FADD)
ACS: 103279978(fadd)
PVT: 110073515(FADD)
PBI: 103054174(FADD)
GJA: 107118889(FADD)
XLA: 108713779(fadd.L) 496403(fadd.S)
XTR: 100379789(fadd)
NPR: 108785454(FADD)
DRE: 562317(fadd)
CCAR: 109047225(fadd)
IPU: 100305064(fadd)
AMEX: 103022073(fadd)
TRU: 101067067(fadd)
LCO: 104933825
NCC: 104955074(fadd)
MZE: 101483780(fadd)
OLA: 100049399(fadd)
XMA: 102230597(fadd)
NFU: 107372902
CSEM: 103378588(fadd)
LCF: 108880505
BPEC: 110174542(fadd)
SASA: 106561969(FADD) 106587129(FADD)
ELS: 105017350(fadd)
SFM: 108941100(fadd)
LCM: 102357786(FADD)
CMK: 103175018(fadd)
SPU: 587131
APLC: 110977598
SKO: 100368353(fadd)
DME: Dmel_CG12297(Fadd)
DSI: Dsimw501_GD20917(Dsim_GD20917)
MDE: 101896030
AGA: AgaP_AGAP007173(FADD)
AAG: 5573014
AME: 100577690
BIM: 100745977
BTER: 100648684
SOC: 105196497
AEC: 105152731
ACEP: 105620481
PBAR: 105430419
HST: 105183935
CFO: 105256948
LHU: 105676271
PGC: 109864088
TCA: 103312947(Fadd)
DPA: 109537323
NVL: 108560749
BMOR: 100529236
PMAC: 106714892
PRAP: 111000403
ZNE: 110837312
CRG: 105323317
MYI: 110449934
OBI: 106871748
LAK: 106160410
AQU: 100633090
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7538907
  Authors
Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM
  Title
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.
  Journal
Cell 81:505-12 (1995)
DOI:10.1016/0092-8674(95)90071-3
  Sequence
[hsa:8772]
Reference
  Authors
Bolze A, Byun M, McDonald D, Morgan NV, Abhyankar A, Premkumar L, Puel A, Bacon CM, Rieux-Laucat F, Pang K, Britland A, Abel L, Cant A, Maher ER, Riedl SJ, Hambleton S, Casanova JL
  Title
Whole-exome-sequencing-based discovery of human FADD deficiency.
  Journal
Am J Hum Genet 87:873-81 (2010)
DOI:10.1016/j.ajhg.2010.10.028
  Sequence
[hsa:8772]

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