KEGG   ORTHOLOGY: K02539Help
Entry
K02539                      KO                                     

Name
MCL1
Definition
myeloid leukemia cell differntiation protein MCL-1
Pathway
PI3K-Akt signaling pathway
Apoptosis
Jak-STAT signaling pathway
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
   04151 PI3K-Akt signaling pathway
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
BRITE hierarchy
Genes
HSA: 
4170(MCL1)
PTR: 
457274(MCL1)
PPS: 
100979595(MCL1)
GGO: 
101137633(MCL1)
PON: 
100436188(MCL1)
NLE: 
100604947(MCL1)
MCC: 
707539(MCL1)
MCF: 
101925224(MCL1)
CSAB: 
103247197(MCL1)
RRO: 
104681074(MCL1)
CJC: 
100406790(MCL1)
SBQ: 
101046604(MCL1)
MMU: 
17210(Mcl1)
RNO: 
60430(Mcl1)
CGE: 
100764237(Mcl1)
NGI: 
103729108(Mcl1)
HGL: 
101724340(Mcl1)
OCU: 
100359222(MCL1)
TUP: 
102472561(MCL1)
CFA: 
403537(MCL1)
AML: 
100484433(MCL1)
UMR: 
103667602(MCL1)
FCA: 
493970(MCL1)
PTG: 
102965985(MCL1)
BTA: 
788087(MCL1)
BOM: 
102283384(MCL1)
PHD: 
102335865(MCL1)
CHX: 
102185798(MCL1)
OAS: 
554329(MCL1)
SSC: 
397648(MCL1)
CFR: 
102509345(MCL1)
BACU: 
103006100(MCL1)
LVE: 
103090946(MCL1)
ECB: 
100054765(MCL1)
MYB: 
102262272(MCL1)
MYD: 
102766301(MCL1)
PALE: 
102884014(MCL1)
LAV: 
100676317(MCL1)
MDO: 
100017262(MCL1)
SHR: 
100928648(MCL1)
GGA: 
395674(MCL1)
MGP: 
100540044(MCL1)
CJO: 
107324527(MCL1)
APLA: 
101803270(MCL1)
GFR: 
102044096(MCL1)
FAB: 
101817366(MCL1)
PHI: 
102111555(MCL1)
CCW: 
104683526(MCL1)
FCH: 
102058939(MCL1)
CLV: 
102097620(MCL1)
AAM: 
106495154(MCL1)
ASN: 
102377228(MCL1)
AMJ: 
102565309(MCL1)
PSS: 
102460228(MCL1)
CMY: 
102947037(MCL1)
ACS: 
100556744(mcl1)
PBI: 
103056794(MCL1)
GJA: 
107120546(MCL1)
XLA: 
100192362(mcl1)
XTR: 
100038211(mcl1)
DRE: 
58122(mcl1a)
TRU: 
101069436(mcl1)
TNG: 
MZE: 
OLA: 
101165916(mcl1)
XMA: 
SASA: 
LCM: 
102350724(MCL1)
CMK: 
SKO: 
HRO: 
LGI: 
OBI: 
VG: 
1486587(FPV039) 19737765(HM89_gp042) 19738046(HM90_gp043) 26122710(ASN15_gp020) 2700183(CNPV058) 2979164(LDVICp188)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
  Authors
Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P, Whyte MK
  Title
Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death.
  Journal
J Biol Chem 275:22136-46 (2000)
Reference
  Authors
Fujise K, Zhang D, Liu J, Yeh ET
  Title
Regulation of apoptosis and cell cycle progression by MCL1. Differential role of  proliferating cell nuclear antigen.
  Journal
J Biol Chem 275:39458-65 (2000)
  Sequence
[hsa:4170]

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