KEGG   ORTHOLOGY: K02580Help
Entry
K02580                      KO                                     

Name
NFKB1
Definition
nuclear factor NF-kappa-B p105 subunit
Pathway
ko01523  Antifolate resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04066  HIF-1 signaling pathway
ko04071  Sphingolipid signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04218  Cellular senescence
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04668  TNF signaling pathway
ko04722  Neurotrophin signaling pathway
ko04917  Prolactin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04926  Relaxin signaling pathway
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05030  Cocaine addiction
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05203  Viral carcinogenesis
ko05206  MicroRNAs in cancer
ko05212  Pancreatic cancer
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05321  Inflammatory bowel disease (IBD)
ko05418  Fluid shear stress and atherosclerosis
Module
M00686  Toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04010 MAPK signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04064 NF-kappa B signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04668 TNF signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04066 HIF-1 signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04071 Sphingolipid signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04024 cAMP signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04151 PI3K-Akt signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04218 Cellular senescence
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04624 Toll and Imd signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04621 NOD-like receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04622 RIG-I-like receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04623 Cytosolic DNA-sensing pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04625 C-type lectin receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04660 T cell receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04658 Th1 and Th2 cell differentiation
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04659 Th17 cell differentiation
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04657 IL-17 signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04662 B cell receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04062 Chemokine signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Endocrine system
   04920 Adipocytokine signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04917 Prolactin signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04926 Relaxin signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Nervous system
   04722 Neurotrophin signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Development
   04380 Osteoclast differentiation
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Aging
   04211 Longevity regulating pathway - mammal
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05202 Transcriptional misregulation in cancers
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05206 MicroRNAs in cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05203 Viral carcinogenesis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05212 Pancreatic cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05221 Acute myeloid leukemia
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05220 Chronic myeloid leukemia
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05215 Prostate cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05222 Small cell lung cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Substance dependence
   05030 Cocaine addiction
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04931 Insulin resistance
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05132 Salmonella infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05131 Shigellosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05133 Pertussis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05134 Legionellosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05152 Tuberculosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05166 HTLV-I infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05162 Measles
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05164 Influenza A
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05161 Hepatitis B
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05160 Hepatitis C
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05168 Herpes simplex infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05169 Epstein-Barr virus infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05165 Human papillomavirus infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05146 Amoebiasis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05145 Toxoplasmosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05140 Leishmaniasis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05142 Chagas disease (American trypanosomiasis)
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  Drug resistance
   01523 Antifolate resistance
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
BRITE hierarchy
Genes
HSA: 4790(NFKB1)
PTR: 461406(NFKB1)
PPS: 100979341(NFKB1)
GGO: 101153465(NFKB1)
PON: 100461595(NFKB1)
NLE: 100581655(NFKB1)
MCC: 710324(NFKB1)
MCF: 102138273(NFKB1)
CSAB: 103236047(NFKB1)
RRO: 104662315(NFKB1)
RBB: 108532817(NFKB1)
CJC: 100415321(NFKB1)
SBQ: 101035787(NFKB1)
MMU: 18033(Nfkb1)
RNO: 81736(Nfkb1)
CGE: 100770607(Nfkb1) 107976968
NGI: 103728077(Nfkb1)
HGL: 101696485(Nfkb1)
CCAN: 109682963(Nfkb1)
OCU: 100349426(NFKB1)
TUP: 102487413(NFKB1)
CFA: 442859(NFKB1)
AML: 100467906(NFKB1)
UMR: 103677947(NFKB1)
ORO: 101371488(NFKB1)
FCA: 100142683(NFKB1)
PTG: 102964232(NFKB1)
AJU: 106984704(NFKB1)
BTA: 616115(NFKB1)
BOM: 102286969(NFKB1)
BIU: 109560296(NFKB1)
PHD: 102316422(NFKB1)
CHX: 102175660(NFKB1)
OAS: 101108228(NFKB1)
SSC: 751869(NFKB1)
CFR: 102505905(NFKB1)
CDK: 105089560(NFKB1)
BACU: 102999230(NFKB1)
LVE: 103068644(NFKB1)
OOR: 101279857(NFKB1)
ECB: 100067894(NFKB1)
EPZ: 103556719(NFKB1)
EAI: 106825951(NFKB1)
MYB: 102255251(NFKB1)
MYD: 102770715(NFKB1)
HAI: 109372541(NFKB1)
RSS: 109451042(NFKB1)
PALE: 102880692(NFKB1)
LAV: 100662194(NFKB1)
TMU: 101351866
MDO: 100014446(NFKB1)
SHR: 100917619(NFKB1)
OAA: 100083819
GGA: 396033(NFKB1)
MGP: 100547165(NFKB1)
CJO: 107313652(NFKB1)
APLA: 101803431(NFKB1)
ACYG: 106045319(NFKB1)
TGU: 100221542(NFKB1)
GFR: 102038208(NFKB1)
FAB: 101815528(NFKB1)
PHI: 102106412(NFKB1)
PMAJ: 107202925(NFKB1)
CCW: 104697095(NFKB1)
FPG: 101920008(NFKB1)
FCH: 102049462(NFKB1)
CLV: 102086078(NFKB1)
AAM: 106491979(NFKB1)
ASN: 102369946(NFKB1)
AMJ: 102558052(NFKB1)
PSS: 102457132(NFKB1)
CMY: 102944582(NFKB1)
CPIC: 101935476(NFKB1)
PVT: 110085341(NFKB1)
PBI: 103049819(NFKB1)
GJA: 107105754(NFKB1)
XLA: 108706736(nfkb1.S) 447632(nfkb1.L)
XTR: 100486083(nfkb1)
NPR: 108789059(NFKB1)
DRE: 565756(nfkb1)
IPU: 108277163(nfkb1)
AMEX: 103038869(nfkb1)
TRU: 101072751(nfkb1)
MZE: 101479063(nfkb1)
OLA: 101167764(nfkb1)
XMA: 102218233(nfkb1)
PRET: 103471905
NFU: 107380900(nfkb1)
CSEM: 103391096(nfkb1)
LCF: 108873754
HCQ: 109516575(nfkb1)
BPEC: 110165498(nfkb1)
ELS: 105029910
LCM: 102356725(NFKB1)
CMK: 103177625(nfkb1)
CIN: 778692(nfkbp105)
SPU: 373533(NFkB)
APLC: 110977565
SKO: 100303565(NFkB)
DME: Dmel_CG11992(Rel)
DSE: Dsec_GM26286(Dsec_Rel)
DSI: Dsimw501_GD20822(Dsim_Rel)
DYA: Dyak_GE24800(Dyak_Rel)
MDE: 101893515
AGA: AgaP_AGAP006747(REL2)
AAG: 5569427
AME: 552247(Rel)
BIM: 100745113
BTER: 100631072
SOC: 105195705
AEC: 105144460
ACEP: 105622536
PBAR: 105431788
HST: 105192416
CFO: 105257468
LHU: 105668729
PGC: 109852148
NVI: 100118169
TCA: 659499(ird)
DPA: 109541423
NVL: 108566978
BMOR: 100124425(Rel)
PMAC: 106720577
PRAP: 110999469
ZNE: 110838042
FCD: 110842715
CRG: 105325572
MYI: 110456751
OBI: 106873263
LAK: 106170138
EPA: 110254138
ADF: 107345201
AQU: 100616089(Nfkb)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2203531
  Authors
Kieran M, Blank V, Logeat F, Vandekerckhove J, Lottspeich F, Le Bail O, Urban MB, Kourilsky P, Baeuerle PA, Israel A
  Title
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product.
  Journal
Cell 62:1007-18 (1990)
DOI:10.1016/0092-8674(90)90275-J
  Sequence
[hsa:4790]
Reference
  Authors
Beinke S, Robinson MJ, Hugunin M, Ley SC
  Title
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.
  Journal
Mol Cell Biol 24:9658-67 (2004)
DOI:10.1128/MCB.24.21.9658-9667.2004

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