KEGG   ORTHOLOGY: K02833Help
Entry
K02833                      KO                                     
Name
HRAS
Definition
GTPase HRas
Pathway
MAPK signaling pathway
ErbB signaling pathway
Chemokine signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Axon guidance
VEGF signaling pathway
Focal adhesion
Tight junction
Gap junction
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Alcoholism
Hepatitis C
Hepatitis B
HTLV-I infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Disease
H00022  
Bladder cancer
H00025  
Penile cancer
H00030  
Cervical cancer
H00032  
Thyroid cancer
H00040  
Squamous cell carcinoma
H00048  
Hepatocellular carcinoma
H00523  
Noonan syndrome and related disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K02833  HRAS; GTPase HRas
   04012 ErbB signaling pathway
    K02833  HRAS; GTPase HRas
   04370 VEGF signaling pathway
    K02833  HRAS; GTPase HRas
   04151 PI3K-Akt signaling pathway
    K02833  HRAS; GTPase HRas
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K02833  HRAS; GTPase HRas
  Cell motility
   04810 Regulation of actin cytoskeleton
    K02833  HRAS; GTPase HRas
  Cell communication
   04510 Focal adhesion
    K02833  HRAS; GTPase HRas
   04530 Tight junction
    K02833  HRAS; GTPase HRas
   04540 Gap junction
    K02833  HRAS; GTPase HRas
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K02833  HRAS; GTPase HRas
   04660 T cell receptor signaling pathway
    K02833  HRAS; GTPase HRas
   04662 B cell receptor signaling pathway
    K02833  HRAS; GTPase HRas
   04664 Fc epsilon RI signaling pathway
    K02833  HRAS; GTPase HRas
   04062 Chemokine signaling pathway
    K02833  HRAS; GTPase HRas
  Endocrine system
   04910 Insulin signaling pathway
    K02833  HRAS; GTPase HRas
   04912 GnRH signaling pathway
    K02833  HRAS; GTPase HRas
   04915 Estrogen signaling pathway
    K02833  HRAS; GTPase HRas
   04917 Prolactin signaling pathway
    K02833  HRAS; GTPase HRas
   04916 Melanogenesis
    K02833  HRAS; GTPase HRas
  Nervous system
   04725 Cholinergic synapse
    K02833  HRAS; GTPase HRas
   04726 Serotonergic synapse
    K02833  HRAS; GTPase HRas
   04720 Long-term potentiation
    K02833  HRAS; GTPase HRas
   04730 Long-term depression
    K02833  HRAS; GTPase HRas
   04722 Neurotrophin signaling pathway
    K02833  HRAS; GTPase HRas
  Development
   04360 Axon guidance
    K02833  HRAS; GTPase HRas
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02833  HRAS; GTPase HRas
   05205 Proteoglycans in cancer
    K02833  HRAS; GTPase HRas
   05203 Viral carcinogenesis
    K02833  HRAS; GTPase HRas
   05214 Glioma
    K02833  HRAS; GTPase HRas
   05216 Thyroid cancer
    K02833  HRAS; GTPase HRas
   05221 Acute myeloid leukemia
    K02833  HRAS; GTPase HRas
   05220 Chronic myeloid leukemia
    K02833  HRAS; GTPase HRas
   05218 Melanoma
    K02833  HRAS; GTPase HRas
   05211 Renal cell carcinoma
    K02833  HRAS; GTPase HRas
   05219 Bladder cancer
    K02833  HRAS; GTPase HRas
   05215 Prostate cancer
    K02833  HRAS; GTPase HRas
   05213 Endometrial cancer
    K02833  HRAS; GTPase HRas
   05223 Non-small cell lung cancer
    K02833  HRAS; GTPase HRas
  Substance dependence
   05034 Alcoholism
    K02833  HRAS; GTPase HRas
  Infectious diseases
   05166 HTLV-I infection
    K02833  HRAS; GTPase HRas
   05161 Hepatitis B
    K02833  HRAS; GTPase HRas
   05160 Hepatitis C
    K02833  HRAS; GTPase HRas
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [Table]
    K02833  HRAS; GTPase HRas
BRITE hierarchy
Genes
HSA: 
3265(HRAS)
PTR: 
466302(HRAS)
PPS: 
100993386(HRAS)
GGO: 
101136425(HRAS)
PON: 
100459427(HRAS)
MCC: 
698830(HRAS)
MMU: 
15461(Hras1)
RNO: 
293621(Hras)
CFA: 
403735(HRAS)
AML: 
FCA: 
751103(H-RAS)
BTA: 
100298939(HRAS)
ECB: 
100055481
MDO: 
100032921
GGA: 
396229(HRAS)
TGU: 
100190361
ACS: 
100565678
XLA: 
399406(hras)
XTR: 
549757(hras)
DRE: 
100151000 550286(hrasa) 553656(hrasb)
TRU: 
101079899
OLA: 
101165278
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Colicelli J
  Title
Human RAS superfamily proteins and related GTPases.
  Journal
Sci STKE 2004:RE13 (2004)
Reference
  Authors
Wolfman A
  Title
Ras isoform-specific signaling: location, location, location.
  Journal
Sci STKE 2001:pe2 (2001)
Reference
  Authors
Olson MF, Marais R
  Title
Ras protein signalling.
  Journal
Semin Immunol 12:63-73 (2000)
Reference
  Authors
Porat-Shliom N, Kloog Y, Donaldson JG
  Title
A unique platform for H-Ras signaling involving clathrin-independent endocytosis.
  Journal
Mol Biol Cell 19:765-75 (2008)
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