KEGG   ORTHOLOGY: K02861Help
Entry
K02861                      KO                                     

Name
RIPK1, RIP1
Definition
receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
Pathway
ko04064  NF-kappa B signaling pathway
ko04210  Apoptosis
ko04217  Necroptosis
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04668  TNF signaling pathway
ko05160  Hepatitis C
ko05169  Epstein-Barr virus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04668 TNF signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04217 Necroptosis
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04621 NOD-like receptor signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04622 RIG-I-like receptor signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04623 Cytosolic DNA-sensing pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
 Human Diseases
  Infectious diseases
   05160 Hepatitis C
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05169 Epstein-Barr virus infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RIPK family [OT]
   K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
BRITE hierarchy
Genes
HSA: 8737(RIPK1)
PTR: 462397(RIPK1)
PPS: 100991521(RIPK1)
GGO: 101153833(RIPK1)
PON: 100449028(RIPK1)
NLE: 100599272(RIPK1)
MCC: 708013(RIPK1)
MCF: 101926590(RIPK1)
CSAB: 103222283(RIPK1)
RRO: 104661228(RIPK1)
RBB: 108514229(RIPK1)
CJC: 100415562(RIPK1)
SBQ: 101047042(RIPK1)
MMU: 19766(Ripk1)
RNO: 306886(Ripk1)
CGE: 100761116(Ripk1)
NGI: 103732937(Ripk1)
HGL: 101696605(Ripk1)
CCAN: 109695449(Ripk1)
OCU: 100352965(RIPK1)
TUP: 102502622(RIPK1)
CFA: 102152063(RIPK1)
AML: 100469872(RIPK1)
UMR: 103664964(RIPK1) 103679877
ORO: 101363053(RIPK1)
FCA: 101087663(RIPK1)
PTG: 102964459(RIPK1)
AJU: 106976163(RIPK1)
BTA: 504727(RIPK1)
BOM: 102279783(RIPK1)
BIU: 109577264(RIPK1)
PHD: 102338792(RIPK1)
CHX: 102178407(RIPK1)
OAS: 101110186(RIPK1)
SSC: 100524751(RIPK1)
CFR: 102516401(RIPK1)
CDK: 105087344(RIPK1)
BACU: 103004292(RIPK1)
LVE: 103079935(RIPK1)
OOR: 101289751(RIPK1)
ECB: 100058015(RIPK1)
EPZ: 103556321(RIPK1)
EAI: 106847888(RIPK1)
MYB: 102245425(RIPK1)
MYD: 102770973(RIPK1)
HAI: 109396595(RIPK1)
RSS: 109458598(RIPK1)
PALE: 102885162(RIPK1)
LAV: 100666489(RIPK1)
TMU: 101341436
MDO: 100028597(RIPK1)
SHR: 100914177(RIPK1)
OAA: 100079746(RIPK1)
GGA: 378921(RIPK1)
MGP: 100542115(RIPK1)
CJO: 107309664(RIPK1)
APLA: 101801990(RIPK1)
ACYG: 106043847(RIPK1)
TGU: 100230522(RIPK1)
GFR: 102038584(RIPK1)
FAB: 101806351(RIPK1)
PHI: 102112432(RIPK1)
PMAJ: 107199939(RIPK1)
FPG: 101913441(RIPK1)
FCH: 102058820(RIPK1)
CLV: 102093314(RIPK1)
EGZ: 104122827(RIPK1)
AAM: 106483966(RIPK1)
ASN: 102367941(RIPK1)
AMJ: 102572936(RIPK1)
PSS: 102455858(RIPK1)
CMY: 102944603(RIPK1)
CPIC: 101949964(RIPK1)
ACS: 100556206(ripk1)
PVT: 110077096(RIPK1)
PBI: 103062047(RIPK1)
GJA: 107123834(RIPK1)
XLA: 108720077(ripk1.S) 734234(ripk1.L)
XTR: 779958(ripk1)
NPR: 108793401(RIPK1)
DRE: 567460(ripk1l)
IPU: 108267903(ripk1)
AMEX: 103045920(ripk1)
TRU: 101073092(ripk1)
LCO: 104931522(ripk1)
NCC: 104943381(ripk1)
MZE: 101477700(ripk1)
OLA: 101167739(ripk1)
XMA: 102226461(ripk1)
PRET: 103479635
NFU: 107383909(ripk1)
CSEM: 103396277(ripk1)
LCF: 108883409(ripk1)
HCQ: 109521234(ripk1)
BPEC: 110158624(ripk1)
SASA: 106569156(ripk1) 106599735
ELS: 105018575(ripk1)
SFM: 108937518 108939327(ripk1)
LCM: 102363596(RIPK1)
CMK: 103176210(ripk1)
CIN: 100184684
APLC: 110987573
CRG: 105318258
MYI: 110452596
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK
  Title
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
  Journal
Cell 137:1112-23 (2009)
DOI:10.1016/j.cell.2009.05.037
Reference
PMID:8612133
  Authors
Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV
  Title
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.
  Journal
Immunity 4:387-96 (1996)
DOI:10.1016/S1074-7613(00)80252-6
  Sequence
[hsa:8737]

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