KEGG   ORTHOLOGY: K03156Help
Entry
K03156                      KO                                     

Name
TNFA
Definition
tumor necrosis factor superfamily, member 2
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
mTOR signaling pathway
Apoptosis
TGF-beta signaling pathway
Osteoclast differentiation
Antigen processing and presentation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Hematopoietic cell lineage
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Type I diabetes mellitus
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
HTLV-I infection
Herpes simplex infection
Proteoglycans in cancer
Asthma
Inflammatory bowel disease (IBD)
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy
Disease
H00079  
Asthma
H00080  
Systemic lupus erythematosus
H00083  
Allograft rejection
H00084  
Graft-versus-host disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04350 TGF-beta signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04064 NF-kappa B signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04668 TNF signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04150 mTOR signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K03156  TNFA; tumor necrosis factor superfamily, member 2
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K03156  TNFA; tumor necrosis factor superfamily, member 2
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04620 Toll-like receptor signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04621 NOD-like receptor signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04622 RIG-I-like receptor signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04650 Natural killer cell mediated cytotoxicity
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04612 Antigen processing and presentation
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04660 T cell receptor signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04664 Fc epsilon RI signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
  Endocrine system
   04920 Adipocytokine signaling pathway
    K03156  TNFA; tumor necrosis factor superfamily, member 2
  Development
   04380 Osteoclast differentiation
    K03156  TNFA; tumor necrosis factor superfamily, member 2
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K03156  TNFA; tumor necrosis factor superfamily, member 2
  Immune diseases
   05310 Asthma
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05322 Systemic lupus erythematosus
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05323 Rheumatoid arthritis
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05321 Inflammatiory bowel disease (IBD)
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05330 Allograft rejection
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05332 Graft-versus-host disease
    K03156  TNFA; tumor necrosis factor superfamily, member 2
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05014 Amyotrophic lateral sclerosis (ALS)
    K03156  TNFA; tumor necrosis factor superfamily, member 2
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05414 Dilated cardiomyopathy (DCM)
    K03156  TNFA; tumor necrosis factor superfamily, member 2
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04930 Type II diabetes mellitus
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K03156  TNFA; tumor necrosis factor superfamily, member 2
  Infectious diseases
   05133 Pertussis
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05134 Legionellosis
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05152 Tuberculosis
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05166 HTLV-I infection
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05164 Influenza A
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05161 Hepatitis B
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05160 Hepatitis C
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05168 Herpes simplex infection
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05146 Amoebiasis
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05144 Malaria
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05145 Toxoplasmosis
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05140 Leishmaniasis
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05142 Chagas disease (American trypanosomiasis)
    K03156  TNFA; tumor necrosis factor superfamily, member 2
   05143 African trypanosomiasis
    K03156  TNFA; tumor necrosis factor superfamily, member 2
Cytokines [BR:ko04052]
 TNF family
  K03156  TNFA; tumor necrosis factor superfamily, member 2
Heparan sulfate/heparin binding proteins [BR:ko00536]
 Cytokines
  K03156  TNFA; tumor necrosis factor superfamily, member 2
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
7124(TNF)
PTR: 
494186(TNF)
PPS: 
GGO: 
PON: 
MCC: 
715467(TNF)
MCF: 
MMU: 
21926(Tnf)
RNO: 
24835(Tnf)
CGE: 
HGL: 
TUP: 
CFA: 
403922(TNF)
AML: 
FCA: 
493755(TNF)
PTG: 
BTA: 
280943(TNF)
BOM: 
PHD: 
CHX: 
SSC: 
397086(TNF)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
XTR: 
DRE: 
405785(tnfa)
TRU: 
654303(tnfa)
MZE: 
OLA: 
XMA: 
LCM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Gaur U, Aggarwal BB
  Title
Regulation of proliferation, survival and apoptosis by members of the TNF superfamily.
  Journal
Biochem Pharmacol 66:1403-8 (2003)
Reference
  Authors
Bodmer JL, Schneider P, Tschopp J.
  Title
The molecular architecture of the TNF superfamily.
  Journal
Trends Biochem Sci 27:19-26 (2002)

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