KEGG   ORTHOLOGY: K03173Help
Entry
K03173                      KO                                     

Name
TRAF2
Definition
TNF receptor-associated factor 2 [EC:2.3.2.27]
Pathway
MAPK signaling pathway
NF-kappa B signaling pathway
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
Apoptosis
Necroptosis
Osteoclast differentiation
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
IL-17 signaling pathway
TNF signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Kaposi's sarcoma-associated herpesvirus infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03173  TRAF2; TNF receptor-associated factor 2
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04064 NF-kappa B signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04668 TNF signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04071 Sphingolipid signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K03173  TRAF2; TNF receptor-associated factor 2
   04217 Necroptosis
    K03173  TRAF2; TNF receptor-associated factor 2
 Organismal Systems
  Immune system
   04621 NOD-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04622 RIG-I-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04657 IL-17 signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  Endocrine system
   04920 Adipocytokine signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  Development
   04380 Osteoclast differentiation
    K03173  TRAF2; TNF receptor-associated factor 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03173  TRAF2; TNF receptor-associated factor 2
   05203 Viral carcinogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
   05222 Small cell lung cancer
    K03173  TRAF2; TNF receptor-associated factor 2
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K03173  TRAF2; TNF receptor-associated factor 2
  Infectious diseases
   05160 Hepatitis C
    K03173  TRAF2; TNF receptor-associated factor 2
   05168 Herpes simplex infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05169 Epstein-Barr virus infection
    K03173  TRAF2; TNF receptor-associated factor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03173  TRAF2; TNF receptor-associated factor 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic Type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     K03173  TRAF2; TNF receptor-associated factor 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03173  TRAF2; TNF receptor-associated factor 2
BRITE hierarchy
Genes
HSA: 
7186(TRAF2)
PTR: 
464876(TRAF2)
PPS: 
100982095(TRAF2)
GGO: 
101144745(TRAF2)
PON: 
100458089(TRAF2)
NLE: 
100590721(TRAF2)
MCC: 
708391(TRAF2)
MCF: 
101925175(TRAF2)
CSAB: 
103239600(TRAF2)
RRO: 
104669650(TRAF2)
RBB: 
108542901(TRAF2)
CJC: 
100404226(TRAF2)
SBQ: 
101035434(TRAF2)
MMU: 
22030(Traf2)
RNO: 
311786(Traf2)
CGE: 
100762099(Traf2)
NGI: 
103741188(Traf2)
HGL: 
101705156(Traf2)
CCAN: 
109699331(Traf2)
TUP: 
CFA: 
480673(TRAF2)
AML: 
100474087(TRAF2)
UMR: 
103675245(TRAF2)
FCA: 
101096363(TRAF2)
PTG: 
102966802(TRAF2)
AJU: 
106989490(TRAF2)
BTA: 
512355(TRAF2)
BOM: 
102275265(TRAF2)
BIU: 
109566626(TRAF2)
PHD: 
102319991(TRAF2)
CHX: 
102184255(TRAF2)
OAS: 
SSC: 
100513840(TRAF2)
CFR: 
102511649(TRAF2)
CDK: 
BACU: 
103013880(TRAF2)
LVE: 
103088738(TRAF2)
ECB: 
100068006(TRAF2)
EPZ: 
103567822(TRAF2)
EAI: 
106845532(TRAF2)
MYB: 
102263277(TRAF2)
MYD: 
102772361(TRAF2)
HAI: 
109381672(TRAF2)
RSS: 
109460915(TRAF2)
PALE: 
102889343(TRAF2)
LAV: 
100670400(TRAF2)
MDO: 
100017243(TRAF2)
SHR: 
100934749(TRAF2)
GGA: 
417287(TRAF2)
MGP: 
100545697(TRAF2)
CJO: 
107321623(TRAF2)
APLA: 
101798982(TRAF2)
ACYG: 
106037085(TRAF2)
TGU: 
100223400(TRAF2)
GFR: 
102033115(TRAF2)
FAB: 
101807272(TRAF2)
PHI: 
102106384(TRAF2)
PMAJ: 
107212160(TRAF2)
CCW: 
104688205(TRAF2)
FPG: 
101911961(TRAF2)
FCH: 
102059920(TRAF2)
CLV: 
102095289(TRAF2)
AAM: 
106494252(TRAF2)
ASN: 
102384689(TRAF2)
AMJ: 
102564363(TRAF2)
PSS: 
102449635(TRAF2)
CMY: 
102941067(TRAF2)
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
108698135(traf2.L) 431974(traf2.S)
XTR: 
100494415(traf2)
NPR: 
108787259(TRAF2)
DRE: 
100005446 557526(traf2b) 564295(traf2a)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
103183006(traf2)
BFO: 
SKO: 
HRO: 
CRG: 
OBI: 
LAK: 
NVE: 
ADF: 
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
He L, Grammer AC, Wu X, Lipsky PE
  Title
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
  Journal
J Biol Chem 279:55855-65 (2004)
DOI:10.1074/jbc.M407284200
Reference
  Authors
Mauro C, Crescenzi E, De Mattia R, Pacifico F, Mellone S, Salzano S, de Luca C, D'Adamio L, Palumbo G, Formisano S, Vito P, Leonardi A
  Title
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis.
  Journal
J Biol Chem 281:2631-8 (2006)
DOI:10.1074/jbc.M502181200
Reference
  Authors
Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC
  Title
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
  Journal
Cell Rep 3:724-33 (2013)
DOI:10.1016/j.celrep.2013.01.031
Reference
PMID:7639698
  Authors
Song HY, Donner DB
  Title
Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.
  Journal
Biochem J 309 ( Pt 3):825-9 (1995)
DOI:10.1042/bj3090825
  Sequence
[hsa:7186]

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