KEGG   ORTHOLOGY: K03173Help
Entry
K03173                      KO                                     

Name
TRAF2
Definition
TNF receptor-associated factor 2 [EC:2.3.2.27]
Pathway
ko04010  MAPK signaling pathway
ko04064  NF-kappa B signaling pathway
ko04071  Sphingolipid signaling pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04217  Necroptosis
ko04380  Osteoclast differentiation
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04920  Adipocytokine signaling pathway
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05160  Hepatitis C
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03173  TRAF2; TNF receptor-associated factor 2
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04064 NF-kappa B signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04668 TNF signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04071 Sphingolipid signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K03173  TRAF2; TNF receptor-associated factor 2
   04217 Necroptosis
    K03173  TRAF2; TNF receptor-associated factor 2
 Organismal Systems
  Immune system
   04621 NOD-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04622 RIG-I-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04657 IL-17 signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  Endocrine system
   04920 Adipocytokine signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  Development
   04380 Osteoclast differentiation
    K03173  TRAF2; TNF receptor-associated factor 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03173  TRAF2; TNF receptor-associated factor 2
   05203 Viral carcinogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
   05222 Small cell lung cancer
    K03173  TRAF2; TNF receptor-associated factor 2
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K03173  TRAF2; TNF receptor-associated factor 2
  Infectious diseases
   05160 Hepatitis C
    K03173  TRAF2; TNF receptor-associated factor 2
   05168 Herpes simplex infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05169 Epstein-Barr virus infection
    K03173  TRAF2; TNF receptor-associated factor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03173  TRAF2; TNF receptor-associated factor 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic Type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     K03173  TRAF2; TNF receptor-associated factor 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03173  TRAF2; TNF receptor-associated factor 2
BRITE hierarchy
Genes
HSA: 7186(TRAF2)
PTR: 464876(TRAF2)
PPS: 100982095(TRAF2)
GGO: 101144745(TRAF2)
PON: 100458089(TRAF2)
NLE: 100590721(TRAF2)
MCC: 708391(TRAF2)
MCF: 101925175(TRAF2)
CSAB: 103239600(TRAF2)
RRO: 104669650(TRAF2)
RBB: 108542901(TRAF2)
CJC: 100404226(TRAF2)
SBQ: 101035434(TRAF2)
MMU: 22030(Traf2)
RNO: 311786(Traf2)
CGE: 100762099(Traf2)
NGI: 103741188(Traf2)
HGL: 101705156(Traf2)
CCAN: 109699331(Traf2)
TUP: 102473925(C8G)
CFA: 480673(TRAF2)
AML: 100474087(TRAF2)
UMR: 103675245(TRAF2)
ORO: 101371938(TRAF2)
FCA: 101096363(TRAF2)
PTG: 102966802(TRAF2)
AJU: 106989490(TRAF2)
BTA: 512355(TRAF2)
BOM: 102275265(TRAF2)
BIU: 109566626(TRAF2)
PHD: 102319991(TRAF2)
CHX: 102184255(TRAF2)
OAS: 101103463 101105235(TRAF2)
SSC: 100513840(TRAF2)
CFR: 102511649(TRAF2)
BACU: 103013880(TRAF2)
LVE: 103088738(TRAF2)
OOR: 101281303(TRAF2)
ECB: 100068006(TRAF2)
EPZ: 103567822(TRAF2)
EAI: 106845532(TRAF2)
MYB: 102263277(TRAF2)
MYD: 102772361(TRAF2)
HAI: 109381672(TRAF2)
RSS: 109460915(TRAF2)
PALE: 102889343(TRAF2)
LAV: 100670400(TRAF2)
TMU: 101354911
MDO: 100017243(TRAF2)
SHR: 100934749(TRAF2)
GGA: 417287(TRAF2)
MGP: 100545697(TRAF2)
CJO: 107321623(TRAF2)
APLA: 101798982(TRAF2)
ACYG: 106037085(TRAF2)
TGU: 100223400(TRAF2)
GFR: 102033115(TRAF2)
FAB: 101807272(TRAF2)
PHI: 102106384(TRAF2)
PMAJ: 107212160(TRAF2)
CCW: 104688205(TRAF2)
FPG: 101911961(TRAF2)
FCH: 102059920(TRAF2)
CLV: 102095289(TRAF2)
EGZ: 104124021(TRAF2)
AAM: 106494252(TRAF2)
ASN: 102384689(TRAF2)
AMJ: 102564363(TRAF2)
PSS: 102449635(TRAF2)
CMY: 102941067(TRAF2)
CPIC: 101933518(TRAF2) 101946577
ACS: 100561141(traf2) 100566904
PVT: 110087462(TRAF2) 110090965
PBI: 103050015 103066991(TRAF2)
GJA: 107115164(TRAF2) 107118266
XLA: 108698135(traf2.L) 431974(traf2.S)
XTR: 100494415(traf2)
NPR: 108787259(TRAF2)
DRE: 100005446 557526(traf2b) 564295(traf2a)
IPU: 108255825 108259928(traf2)
AMEX: 103028261(traf2) 103036375
CMK: 103183006(traf2)
APLC: 110981046
MYI: 110464971
OBI: 106879639
HMG: 100213781
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
He L, Grammer AC, Wu X, Lipsky PE
  Title
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
  Journal
J Biol Chem 279:55855-65 (2004)
DOI:10.1074/jbc.M407284200
Reference
  Authors
Mauro C, Crescenzi E, De Mattia R, Pacifico F, Mellone S, Salzano S, de Luca C, D'Adamio L, Palumbo G, Formisano S, Vito P, Leonardi A
  Title
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis.
  Journal
J Biol Chem 281:2631-8 (2006)
DOI:10.1074/jbc.M502181200
Reference
  Authors
Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC
  Title
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
  Journal
Cell Rep 3:724-33 (2013)
DOI:10.1016/j.celrep.2013.01.031
Reference
PMID:7639698
  Authors
Song HY, Donner DB
  Title
Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.
  Journal
Biochem J 309 ( Pt 3):825-9 (1995)
DOI:10.1042/bj3090825
  Sequence
[hsa:7186]

DBGET integrated database retrieval system