KEGG   ORTHOLOGY: K03175Help
Entry
K03175                      KO                                     

Name
TRAF6
Definition
TNF receptor-associated factor 6
Pathway
MAPK signaling pathway
NF-kappa B signaling pathway
Ubiquitin mediated proteolysis
Endocytosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Neurotrophin signaling pathway
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Measles
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Small cell lung cancer
Module
M00686  
Toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03175  TRAF6; TNF receptor-associated factor 6
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04064 NF-kappa B signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K03175  TRAF6; TNF receptor-associated factor 6
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04621 NOD-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04622 RIG-I-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  Nervous system
   04722 Neurotrophin signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  Development
   04380 Osteoclast differentiation
    K03175  TRAF6; TNF receptor-associated factor 6
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
   05222 Small cell lung cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  Infectious diseases
   05133 Pertussis
    K03175  TRAF6; TNF receptor-associated factor 6
   05152 Tuberculosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05162 Measles
    K03175  TRAF6; TNF receptor-associated factor 6
   05160 Hepatitis C
    K03175  TRAF6; TNF receptor-associated factor 6
   05168 Herpes simplex infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05169 Epstein-Barr virus infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05145 Toxoplasmosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05140 Leishmaniasis
    K03175  TRAF6; TNF receptor-associated factor 6
   05142 Chagas disease (American trypanosomiasis)
    K03175  TRAF6; TNF receptor-associated factor 6
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K03175  TRAF6; TNF receptor-associated factor 6
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  single Ring-finger type E3
   TRAF proteins
    K03175  TRAF6; TNF receptor-associated factor 6
BRITE hierarchy
Genes
HSA: 
7189(TRAF6)
PTR: 
451702(TRAF6)
PPS: 
100983960(TRAF6)
GGO: 
101152087(TRAF6)
PON: 
100449432(TRAF6)
NLE: 
100595327(TRAF6)
MCC: 
716907(TRAF6)
MCF: 
102128596(TRAF6)
CJC: 
100395364(TRAF6)
MMU: 
22034(Traf6)
RNO: 
311245(Traf6)
CGE: 
100753700(Traf6)
NGI: 
103749513(Traf6)
HGL: 
101697126(Traf6)
OCU: 
100343190(TRAF6)
TUP: 
102482652(TRAF6)
CFA: 
100688110(TRAF6)
AML: 
UMR: 
103659308(TRAF6)
FCA: 
101099750(TRAF6)
PTG: 
102960157(TRAF6)
BTA: 
539124(TRAF6)
BOM: 
102285891(TRAF6)
PHD: 
102318296(TRAF6)
CHX: 
102172830(TRAF6)
OAS: 
101107132(TRAF6)
SSC: 
396629(TRAF6)
CFR: 
102520181(TRAF6)
BACU: 
103018592(TRAF6)
LVE: 
ECB: 
100052296(TRAF6)
MYB: 
102250946(TRAF6)
MYD: 
102765934(TRAF6)
PALE: 
102886476(TRAF6)
MDO: 
100010055(TRAF6)
SHR: 
100922331(TRAF6)
OAA: 
100077058(TRAF6)
GGA: 
423163(TRAF6)
MGP: 
100544809(TRAF6)
APLA: 
101802411(TRAF6)
TGU: 
100229606(TRAF6)
FAB: 
101817601(TRAF6)
PHI: 
102105183(TRAF6)
FPG: 
101912003(TRAF6)
FCH: 
102058044(TRAF6)
CLV: 
102083770(TRAF6)
ASN: 
102368234(TRAF6)
AMJ: 
102572036(TRAF6)
PSS: 
102463398(TRAF6)
CMY: 
102938959(TRAF6)
ACS: 
100561211(traf6)
PBI: 
103052063(TRAF6)
XLA: 
444777(traf6-b) 734929(traf6-a)
XTR: 
493524(traf6)
DRE: 
554561(traf6)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102353931(TRAF6)
CMK: 
103186026(traf6)
CIN: 
778949(zf(traf/ring)-3)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AME: 
551819(Traf6)
TCA: 
661716(Traf2)
BMOR: 
API: 
PHU: 
ISC: 
HRO: 
LGI: 
NVE: 
DPP: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ha H, Han D, Choi Y
  Title
TRAF-mediated TNFR-family signaling.
  Journal
Curr Protoc Immunol Chapter 11:Unit11.9D (2009)
Reference
  Authors
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK
  Title
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
  Journal
Science 325:1134-8 (2009)
  Sequence
[hsa:7189]

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