KEGG   ORTHOLOGY: K03175Help
Entry
K03175                      KO                                     

Name
TRAF6
Definition
TNF receptor-associated factor 6 [EC:2.3.2.27]
Pathway
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04064  NF-kappa B signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04140  Autophagy - animal
ko04144  Endocytosis
ko04214  Apoptosis - fly
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04722  Neurotrophin signaling pathway
ko05133  Pertussis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05162  Measles
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Module
M00686  Toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03175  TRAF6; TNF receptor-associated factor 6
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04013 MAPK signaling pathway - fly
    K03175  TRAF6; TNF receptor-associated factor 6
   04064 NF-kappa B signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K03175  TRAF6; TNF receptor-associated factor 6
   04140 Autophagy - animal
    K03175  TRAF6; TNF receptor-associated factor 6
  Cell growth and death
   04214 Apoptosis - fly
    K03175  TRAF6; TNF receptor-associated factor 6
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04621 NOD-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04622 RIG-I-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04657 IL-17 signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  Nervous system
   04722 Neurotrophin signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  Development
   04380 Osteoclast differentiation
    K03175  TRAF6; TNF receptor-associated factor 6
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
   05222 Small cell lung cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  Infectious diseases
   05133 Pertussis
    K03175  TRAF6; TNF receptor-associated factor 6
   05152 Tuberculosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05162 Measles
    K03175  TRAF6; TNF receptor-associated factor 6
   05160 Hepatitis C
    K03175  TRAF6; TNF receptor-associated factor 6
   05168 Herpes simplex infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05169 Epstein-Barr virus infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05145 Toxoplasmosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05140 Leishmaniasis
    K03175  TRAF6; TNF receptor-associated factor 6
   05142 Chagas disease (American trypanosomiasis)
    K03175  TRAF6; TNF receptor-associated factor 6
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K03175  TRAF6; TNF receptor-associated factor 6
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03175  TRAF6; TNF receptor-associated factor 6
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K03175  TRAF6; TNF receptor-associated factor 6
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03175  TRAF6; TNF receptor-associated factor 6
BRITE hierarchy
Genes
HSA: 7189(TRAF6)
PTR: 451702(TRAF6)
PPS: 100983960(TRAF6)
GGO: 101152087(TRAF6)
PON: 100449432(TRAF6)
NLE: 100595327(TRAF6)
MCC: 716907(TRAF6)
MCF: 102128596(TRAF6)
CSAB: 103237554(TRAF6)
RRO: 104658364(TRAF6)
RBB: 108535559(TRAF6)
CJC: 100395364(TRAF6)
SBQ: 101033308(TRAF6)
MMU: 22034(Traf6)
RNO: 311245(Traf6)
CGE: 100753700(Traf6)
NGI: 103749513(Traf6)
HGL: 101697126(Traf6)
CCAN: 109693564(Traf6)
OCU: 100343190(TRAF6)
TUP: 102482652(TRAF6)
CFA: 100688110(TRAF6)
AML: 100483216(TRAF6)
UMR: 103659308(TRAF6)
ORO: 101362953(TRAF6)
FCA: 101099750(TRAF6)
PTG: 102960157(TRAF6)
AJU: 106976941(TRAF6)
BTA: 539124(TRAF6)
BOM: 102285891(TRAF6)
BIU: 109565970
PHD: 102318296(TRAF6)
CHX: 102172830(TRAF6)
OAS: 101107132(TRAF6)
SSC: 396629(TRAF6)
CFR: 102520181(TRAF6)
CDK: 105106823(TRAF6)
BACU: 103018592(TRAF6)
OOR: 101277553(TRAF6)
ECB: 100052296(TRAF6)
EPZ: 103560236(TRAF6)
EAI: 106837480(TRAF6)
MYB: 102250946(TRAF6)
MYD: 102765934(TRAF6)
HAI: 109381153(TRAF6)
RSS: 109450845(TRAF6)
PALE: 102886476(TRAF6)
LAV: 100671471(TRAF6)
TMU: 101345331
MDO: 100010055(TRAF6)
SHR: 100922331(TRAF6)
OAA: 100077058(TRAF6)
GGA: 423163(TRAF6)
MGP: 100544809(TRAF6)
CJO: 107314700(TRAF6)
APLA: 101802411(TRAF6)
ACYG: 106044346(TRAF6)
TGU: 100229606(TRAF6)
GFR: 102040197(TRAF6)
FAB: 101817601(TRAF6)
PHI: 102105183(TRAF6)
PMAJ: 107206210(TRAF6)
CCW: 104693976(TRAF6)
FPG: 101912003(TRAF6)
FCH: 102058044(TRAF6)
CLV: 102083770(TRAF6)
EGZ: 104134046(TRAF6)
AAM: 106498355(TRAF6)
ASN: 102368234(TRAF6)
AMJ: 102572036(TRAF6)
PSS: 102463398(TRAF6)
CMY: 102938959(TRAF6)
CPIC: 101953645(TRAF6)
ACS: 100561211(traf6)
PVT: 110090250(TRAF6)
PBI: 103052063(TRAF6)
GJA: 107116985(TRAF6)
XLA: 444777(traf6.L) 734929(traf6.S)
XTR: 493524(traf6)
NPR: 108787821(TRAF6)
DRE: 554561(traf6)
CCAR: 109065463 109093401(traf6)
IPU: 108259200(traf6)
AMEX: 103021325(traf6)
TRU: 101071368(traf6)
LCO: 104920634(traf6)
NCC: 104948752(traf6)
MZE: 101469001(traf6)
OLA: 101161132(traf6)
XMA: 102220826(traf6)
PRET: 103462724(traf6)
NFU: 107383589(traf6)
CSEM: 103378810(traf6)
LCF: 108887802(traf6)
HCQ: 109525774(traf6)
BPEC: 110162549(traf6)
ELS: 105025313(traf6)
SFM: 108934700 108942315(traf6)
LCM: 102353931(TRAF6)
CMK: 103186026(traf6)
CIN: 778949(zf(traf/ring)-3)
DME: Dmel_CG10961(Traf6)
DSI: Dsimw501_GD16124(Dsim_GD16124)
MDE: 101890213
AME: 551819(TRAF2)
BIM: 100744070
BTER: 100647374
AEC: 105149418
ACEP: 105625455
PBAR: 105422477
HST: 105190721
CFO: 105257286
LHU: 105676050
PGC: 109851970
TCA: 661716(Traf2)
DPA: 109541363
BMOR: 100862757
PMAC: 106715656
PRAP: 111001407
API: 100575739
DNX: 107165263
ZNE: 110826527
FCD: 110850863
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK
  Title
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
  Journal
Science 325:1134-8 (2009)
DOI:10.1126/science.1175065
  Sequence
[hsa:7189]
Reference
PMID:8837778
  Authors
Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV
  Title
TRAF6 is a signal transducer for interleukin-1.
  Journal
Nature 383:443-6 (1996)
DOI:10.1038/383443a0
  Sequence
[hsa:7189]

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