KEGG   ORTHOLOGY: K03870Help
Entry
K03870                      KO                                     
Name
CUL2
Definition
cullin 2
Pathway
HIF-1 signaling pathway
Ubiquitin mediated proteolysis
Pathways in cancer
Renal cell carcinoma
Module
M00383  
ECV complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03870  CUL2; cullin 2
 Environmental Information Processing
  Signal transduction
   04066 HIF-1 signaling pathway
    K03870  CUL2; cullin 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03870  CUL2; cullin 2
   05211 Renal cell carcinoma
    K03870  CUL2; cullin 2
KEGG pathway modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00383  ECV complex [BR:ko04121]
     K03870  CUL2; cullin 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   ECV complex
    Cullin
     K03870  CUL2; cullin 2
BRITE hierarchy
Genes
HSA: 
8453(CUL2)
PTR: 
450399(CUL2)
PPS: 
100987655(CUL2)
GGO: 
101152077(CUL2)
PON: 
100174361(CUL2)
MCC: 
698384(CUL2)
MMU: 
71745(Cul2)
RNO: 
361258(Cul2)
CFA: 
477952(CUL2)
AML: 
100475344(CUL2)
FCA: 
101094429(CUL2)
BTA: 
535219(CUL2)
SSC: 
100512186(CUL2)
ECB: 
100054982(CUL2)
MDO: 
100018154(CUL2)
SHR: 
100934724(CUL2)
OAA: 
100074001(CUL2)
GGA: 
420467(CUL2)
MGP: 
100550749(CUL2)
TGU: 
100221330(CUL2)
ACS: 
100560323
XLA: 
379729(cul2)
XTR: 
100492608
DRE: 
336088(cul2)
TRU: 
101079145
OLA: 
101155234
BFO: 
BRAFLDRAFT_89705
CIN: 
100183130(cul2)
SPU: 
100890302
DME: 
Dmel_CG1512(Cul-2)
DPO: 
Dpse_GA13508
DAN: 
Dana_GF15487
DER: 
Dere_GG21342
DPE: 
Dper_GL25796
DSE: 
Dsec_GM16141
DSI: 
Dsim_GD24329
DYA: 
Dyak_GE12924
DGR: 
Dgri_GH10784
DMO: 
Dmoj_GI17442
DVI: 
Dvir_GJ14230
AGA: 
AgaP_AGAP003605
AAG: 
AaeL_AAEL006929
AME: 
725467(cul-2)
NVI: 
100114184(NV18061)
TCA: 
663441
API: 
100164876
PHU: 
Phum_PHUM422860
ISC: 
IscW_ISCW021256
CEL: 
CELE_ZK520.4(cul-2)
CBR: 
CBG18282(Cbr-cul-2)
BMY: 
Bm1_45370
SMM: 
Smp_079740
NVE: 
NEMVE_v1g178205
HMG: 
100201574
TAD: 
TRIADDRAFT_22645
AQU: 
100637741
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kamura T.
  Title
[Cullin-based E3 family] Japanese
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
  Authors
Mahrour N, Redwine WB, Florens L, Swanson SK, Martin-Brown S, Bradford WD, Staehling-Hampton K, Washburn MP, Conaway RC, Conaway JW
  Title
Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.
  Journal
J Biol Chem 283:8005-13 (2008)
Reference
  Authors
Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI.
  Title
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
  Journal
Genes Dev 18:3055-65 (2004)
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