KEGG   ORTHOLOGY: K03871Help
Entry
K03871                      KO                                     

Name
VHL
Definition
von Hippel-Lindau disease tumor supressor
Pathway
HIF-1 signaling pathway
Ubiquitin mediated proteolysis
Pathways in cancer
Renal cell carcinoma
Module
M00383  
ECV complex
Disease
H00021  
Renal cell carcinoma
H00236  
Congenital polycythemia
H00559  
von Hippel-Lindau syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03871  VHL; von Hippel-Lindau disease tumor supressor
 Environmental Information Processing
  Signal transduction
   04066 HIF-1 signaling pathway
    K03871  VHL; von Hippel-Lindau disease tumor supressor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03871  VHL; von Hippel-Lindau disease tumor supressor
   05211 Renal cell carcinoma
    K03871  VHL; von Hippel-Lindau disease tumor supressor
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00383  ECV complex
     K03871  VHL; von Hippel-Lindau disease tumor supressor
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   ECV complex
    target recognizing subunit (VHL box)
     K03871  VHL; von Hippel-Lindau disease tumor supressor
BRITE hierarchy
Genes
HSA: 
7428(VHL)
PTR: 
749769(VHL)
PPS: 
100980663(VHLL) 100986949(VHL)
GGO: 
PON: 
NLE: 
100600696(VHL) 100606521(VHLL)
MCC: 
CJC: 
MMU: 
22346(Vhl)
RNO: 
24874(Vhl)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
494000(VHL)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
540957(VHL)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
100074049(VHLL)
GGA: 
416117(VHL)
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XTR: 
549121(vhl)
DRE: 
791202(vhl) 795635(vhll)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
726161(Vhl)
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG17370(Cbr-vhl-1)
HRO: 
LGI: 
TAD: 
CRE: 
CME: 
SLA: 
TBR: 
Tb927.6.510(Tb06.28F21.90)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Mahrour N, Redwine WB, Florens L, Swanson SK, Martin-Brown S, Bradford WD, Staehling-Hampton K, Washburn MP, Conaway RC, Conaway JW
  Title
Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.
  Journal
J Biol Chem 283:8005-13 (2008)
  Sequence
[hsa:7428]
Reference
  Authors
Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI.
  Title
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
  Journal
Genes Dev 18:3055-65 (2004)
  Sequence
[hsa:7428]
Reference
  Authors
Adryan B, Decker HJ, Papas TS, Hsu T
  Title
Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila.
  Journal
Oncogene 19:2803-11 (2000)
  Sequence

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