KEGG   ORTHOLOGY: K03873Help
Entry
K03873                      KO                                     
Name
TCEB2
Definition
transcription elongation factor B, polypeptide 2
Pathway
HIF-1 signaling pathway
Ubiquitin mediated proteolysis
Pathways in cancer
Renal cell carcinoma
Module
M00383  
ECV complex
M00388  
ECS complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03873  TCEB2; transcription elongation factor B, polypeptide 2
 Environmental Information Processing
  Signal transduction
   04066 HIF-1 signaling pathway
    K03873  TCEB2; transcription elongation factor B, polypeptide 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03873  TCEB2; transcription elongation factor B, polypeptide 2
   05211 Renal cell carcinoma
    K03873  TCEB2; transcription elongation factor B, polypeptide 2
KEGG pathway modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00383  ECV complex [BR:ko04121]
     K03873  TCEB2; transcription elongation factor B, polypeptide 2
    M00388  ECS complex [BR:ko04121]
     K03873  TCEB2; transcription elongation factor B, polypeptide 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   ECV complex
    adoptor protein
     K03873  TCEB2; transcription elongation factor B, polypeptide 2
   ECS complex
    adoptor protein
     K03873  TCEB2; transcription elongation factor B, polypeptide 2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    Other NER factors
     K03873  TCEB2; transcription elongation factor B, polypeptide 2
BRITE hierarchy
Genes
HSA: 
6923(TCEB2)
PTR: 
750134(TCEB2)
PPS: 
GGO: 
101148160(TCEB2)
PON: 
100456083(TCEB2)
MCC: 
715218(TCEB2)
MMU: 
67673(Tceb2)
RNO: 
81807(Tceb2)
CFA: 
479873(TCEB2)
AML: 
FCA: 
101101182
BTA: 
617277(TCEB2)
SSC: 
100519651
ECB: 
100068774
MDO: 
100018279
SHR: 
100915663
OAA: 
100090222
GGA: 
430688
ACS: 
100562302
XLA: 
380106(tceb2)
XTR: 
394559(tceb2)
DRE: 
192341(tceb2)
TRU: 
101068670 101070508
OLA: 
101169818 101171166
BFO: 
BRAFLDRAFT_87435
CIN: 
100186014
SPU: 
753537
DME: 
Dmel_CG4204(Elongin-B)
DPO: 
Dpse_GA26968
DAN: 
Dana_GF18332
DER: 
Dere_GG15357
DPE: 
Dper_GL13928
DSE: 
Dsec_GM23182
DSI: 
Dsim_GD20055
DWI: 
Dwil_GK22717
DYA: 
Dyak_GE25062
DGR: 
Dgri_GH16190
DMO: 
Dmoj_GI22177
DVI: 
Dvir_GJ24297
AGA: 
AgaP_AGAP003154
AAG: 
AaeL_AAEL000084
CQU: 
CpipJ_CPIJ002389
AME: 
551511(Elongin-B)
NVI: 
100120540(NV16800)
TCA: 
657699
API: 
100165197(Tceb2)
PHU: 
Phum_PHUM529480
ISC: 
IscW_ISCW002622
CEL: 
CELE_Y41C4A.10(elb-1)
CBR: 
CBG13236(Cbr-elb-1)
BMY: 
Bm1_23945
SMM: 
Smp_072380
NVE: 
NEMVE_v1g116912
HMG: 
100198637
TAD: 
TRIADDRAFT_59247
AQU: 
100633650
ALY: 
ARALYDRAFT_495882
CSV: 
101217288(UBI-1) 101223495
RCU: 
RCOM_0444520
POP: 
POPTR_561357
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kamura T.
  Title
[Cullin-based E3 family] Japanese
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
  Authors
Mahrour N, Redwine WB, Florens L, Swanson SK, Martin-Brown S, Bradford WD, Staehling-Hampton K, Washburn MP, Conaway RC, Conaway JW
  Title
Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.
  Journal
J Biol Chem 283:8005-13 (2008)
Reference
  Authors
Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI.
  Title
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
  Journal
Genes Dev 18:3055-65 (2004)
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